Immunoregulation Unit and CNRS URA 1961
Department of Immunology
Head: Lars Rogge, PhD
Immune-mediated inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, spondyloarthritis or type 1 diabetes cause significant morbidity and are a substantial burden for the affected individuals and the society. The immune mechanisms underlying the pathogenesis of these diseases remain largely unknown, which is an important roadblock with respect to early diagnosis and the development of more specific and effective therapies.
The main goal of the Immunoregulation Unit is to unravel the fundamental mechanisms that control the differentiation and function of human T lymphocyte populations with pro-inflammatory and regulatory activities and to study their roles in the pathogenesis of inflammatory diseases.
During the past years, we have performed an integrated analysis of the signaling pathways, epigenetic modifications and genetic networks involved in T helper cell differentiation. We have studied how signals originating at the T cell receptor and at cytokine receptors are integrated to shape T helper subset-specific gene expression programs in primary human T lymphocytes. We have analyzed in particular the synergy of transcription factors and chromatin remodeling complexes to induce epigenetic changes and gene transcription during the development of T helper type 1 (Th1) cells.
We currently pursue the following projects:
1. Linking genotype, cell function and pathology in inflammatory diseases
2. Epigenetic mechanisms controlling the stability and plasticity of CD4+ T cell subsets
3. Analysis of human CD4+FOXP3+ regulatory T cell populations in homeostatic conditions and during graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation