Publications

Thomas Bourgeron Human Genetics and Cognitive Functions

 

Schmeisser MJ, Ey E, Kuebler A, Bockmann J, Wegener S, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, tom Dieck S, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED and Boeckers TM. (2012) Hyperactivity and autistic-like behaviours in mice lacking ProSAP1/Shank2. Nature 486 256-260.

 

Leblond CS, Heinrich J, Delorme R, Proepper C, Betancur C, Huguet G, Konyukh M, Chaste P, Ey E, Rastam M, Anckarsäter H, Nygren G, Gillberg IC, Melke J, Toro R, Regnault B, Fauchereau F, Mercati O, Lemière N, Skuse D, Poot M, Holt R, Monaco AP, Järvelä I, Kantojärvi K, Vanhala R, Curran S, Collier DA, Bolton P, Chiocchetti A, Klauck SM, Poustka F, Freitag CM, Waltes R, Kopp M, Duketis E, Bacchelli E, Minopoli F, Ruta L, Battaglia A, Mazzone L, Maestrini E, Sequeira AF, Oliveira B, Vicente A, Oliveira G, Pinto D, Scherer SW, Zelenika D, Delepine M, Lathrop M, Bonneau D, Guinchat V, Devillard F, Assouline B, Mouren MC, Leboyer M, Gillberg C, Boeckers TM, Bourgeron T. (2012) Genetic and functional analyses of SHANK2 mutations provide evidence for a multiple hit model of autism spectrum disorders. PLoS Genetics 8(2):e1002521.

 

Toro R,  Konyukh M, Delorme R, Leblond C, Chaste P, Fauchereau F, Coleman M, Leboyer M, Gillberg C and Bourgeron T. (2010) Key role for gene dosage and synaptic homeostasis in autism spectrum disorders. Trends in Genetics 26:363-372.

 

Pinto D, Pagnamenta A, Klei L Merico D, Anney R , Merico D, Regan R, Conroy J, Magalhaes T, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T et al. (2010) Functional impact of global rare copy number variation in autismNature 466 : 368-72.

 

Jamain S., Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J,Bourgeron T, Ehrenreich H, and Brose N. (2008) Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci U S A. 105:1710-1715.

 

MelkeJ, Goubran-BotrosH, ChasteP, BetancurC, NygrenG, AnckarsäterH, Rastam M, StåhlbergO, GillbergIC, DelormeR, ChabaneN, Mouren-SimeoniMC, FauchereauF, DurandCM, ChevalierF, DrouotX, ColletC, LaunayJM, LeboyerM, GillbergC, and BourgeronT (2008) Abnormal Melatonin Synthesis in Autism Spectrum Disorders Molecular Psychiatry 13:90-98.

 

The Autism Genome Project Consortium; (2007) Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics. 39:319-28.

 

 

Durand C, Betancur C, Boeckers TM, Bockmann J, ChasteP, FauchereauF, NygrenG, Rastam M, Gillberg IC, Anckarsäter H, SponheimE, Goubran-BotrosH, DelormeR, ChabaneN, Mouren-SimeoniMC,de MasP, BiethE, RogéB, HéronD, BurglenL, GillbergC, LeboyerM, Bourgeron T (2007) Mutations of the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nature Genetics 39:25-7.

 

Belmonte MK and Bourgeron T. (2006) Fragile X Syndrome and Autism at the Intersection of Genetic and Neuronal Networks. Nature Neuroscience 9:1221-1225.

Jamain S, Quach H, Betancur C, Råstam M, Colineaux C, Gillberg IC, Soderstrom H, Giros B, Leboyer M, Gillberg C, Bourgeron T and the Paris study (2003). Mutations of the X-linked neuroligins NLGN3 and NLGN4 are associated with autism Nature Genetics 34, 27-29.

 

Unité Uwe MaskosIntegrative Neurobiology of Cholinergic Systems

 

1. S Tolu, R Eddine, F Marti, V David, M Graupner, S Pons, M Baudonnat, M Husson, M Besson, C Reperant, J Zemdegs, C Pagès, YAH Hay, B Lambolez, J Caboche, B Gutkin, AM Gardier, J-P Changeux, P Faure & U Maskos (2012) Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement. Mol Psychiatry EPub 3 July 2012

 

2. K Guillem, RB Poorthuis, B Bloem, M Loos, AB Smit, U Maskos, S Spijker & H Mansvelder (2011) Nicotinic acetylcholine receptor b2 subunits in the medial prefrontal cortex control attention. Science 333, 888-891.

 

3. ME Avale, J Chabout, S Pons, P Serreau, F de Chaumont, JC Olivo-Marin, JP Bourgeois, U Maskos, JP Changeux& S Granon(2011) Prefrontal nicotinic receptors control novel social interaction between mice. FASEB J. 25, 2145-2155.

 

4. S Frahm, MA Slimak, L Ferrarese, J Santos-Torres, B Antolin-Fontes, S Auer, S Filkin, S Pons, J-F Fontaine, V Tsetlin, U Maskos & I Ibanez-Tallon (2011) Aversion to nicotine is regulated by the balanced activity of b4 and α5 nicotinic receptor subunits in the medial habenula. Neuron 70, 522-535.

 

5. R Exley*, N Maubourguet*, V David*, R Eddine, A Evrard, S Pons, F Marti, S Threlfell, P Cazala, JM McIntosh, J-P Changeux, U Maskos, SJ Cragg & P Faure (2011) Distinct contributions of nicotinic acetylcholine receptor subunit α4 and subunit α6 to the reinforcing effects of nicotine. Proc Natl Acad Sci U S A 108, 7577-7582.

 

6. S Tolu, ME Avale, H Nakatani, S Pons, S Parnaudeau, F Tronche, A Vogt, H Monyer, F de Chaumont, J-C Olivo-Marin, J-P Changeux & U Maskos (2010) A versatile system for the neuronal subtype specific expression of lentiviral vectors. FASEB J. 24, 723-730.

 

7. ME Avale, P Faure, S Pons, P Robledo, T Deltheil, DJ David, AM Gardier, R Maldonado, S Granon, J-P Changeux & U Maskos (2008) Interplay of b2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion. Proc. Natl. Acad. Sci. USA105, 15991-15996.

 

8. S Pons, L Fattore, G Cossu, E Porcu, S Tolu, J-P Changeux, U Maskos* & W Fratta* (2008) Crucial role of a4 and a6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration. J. Neurosci. 28, 12318-12327.

 

9. P Vincent*, U Maskos*, I Charvet, L Bourgeais, L Stoppini, R Lambert, J-P Changeux, P Meda & D Tritsch (2006) Live imaging of neural structure and function by fibered confocal fluorescence microscopy. EMBO Rep. 7, 1154-1161.

 

10. U Maskos, BE Molles, S Pons, M Besson, BP Guiard, J-P Guilloux, A Evrard, P Cazala, A Cormier, M Mameli-Engvall, N Dufour, I Cloëz-Tayarani, A-P Bemelmans, J Mallet, AM Gardier, V David, P Faure, S Granon & J-P Changeux (2005) Recovery of nicotine reinforcement and cognitive functions by targeted expression of nicotinic receptors. Nature 436, 99-106.

 

Jean-Michel HEARD / Biotherapies for neurodegenrative diseases

 

Ausseil J, Desmaris N, Bigou S, Attali R, Corbineau S, Vitry S, Parent M, Cheillan D, Fuller M, Maire I, Vanier MT, Heard JM. (2008) Early neurodegeneration progresses independently of microglial activation by heparan sulfate in the brain of mucopolysaccharidosis IIIB mice. PLoS ONE. 3(5):e2296.

 

Bohl D, Liu S, Blanchard S, Hocquemiller M, Haase G, Heard JM. (2008) Directed evolution of motor neurons from genetically engineered neural precursors. Stem Cells. 10:2564-75.

 

Liu S, Bohl D, Blanchard S, Bacci J, Saïd G, Heard JM. (2009) Combination of Microsurgery and Gene Therapy for Spinal Dorsal Root Injury Repair. Mol Ther. 17:992-1002.

 

Ciron C, Cressant A, Roux F, Raoul S, Cherel Y, Hantraye P, Déglon N, Schwartz B, Barkats M, Heard JM, Tardieu M, Moullier P, Colle MA. (2009) Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution. Hum Gene Ther. 20:350-60.

 

Vitry S, Ausseil J, Hocquemiller M, Bigou S, Dos Santos Coura R, Heard JM. (2009) Enhanced degradation of synaptophysin by the proteasome in mucopolysaccharidosis type IIIB. Mol Cell Neurosci. 41:8-18.

 

Jacquier A, Blanchard S, Bellouze S, Bohl D, Haase G. (2009) Astrocytic protection of spinal motor neurons but not cortical neurons against loss of Als2/alsin function.Hum Mol Genet.18: 2127-2139.

 

HocquemillerM, Vitry S, Bigou S, BruyèreJ, AusseilJ, HeardJM. (2010) GAP43 overexpression and enhanced neurite outgrowth in mucopolysaccharidosis type IIIB cortical neuron cultures. J. Neurosci. Res. 88 :202-213

 

Liu S., Blanchard S., Bigou S., Vitry S., Bohl D., Heard J.M. (2010) Neurotrophin 3 improves delayed reconstruction of sensory pathways after cervical dorsal root injury, Neurosurgery, PMID: 21135740

 

Vitry S., Bruyère J., Hocquemiller M., Bigou S., Ausseil J., Colle M.A., Prévost M.C., Heard J.M. (2010) Storage vesicles in neurons are related to Golgi complex alterations in mucopolysaccharidosis IIIB. Am J Pathol, 177(6):2984-99.

 

Ellinwood M., Ausseil J., Desmaris N., Bigou S., Liu S., Jens J.J., Snella E.M., Mohammed E., Thomson C., Raoul S., Joussemet B., Roux F., Chérel Y., Lajat Y., Piraud M., Benchaouir R., Hermening S., Petry H., Froissart R., Tardieu M., Ciron C., Moullier P., Parkes J., Kline K., Maire I., Vanier M.T., Heard J.M., Colle M.A.(2011) Safe, efficient and reproducible gene therapy of the brain in the dog models of Sanfilippo and Hurler syndromes. Mol Ther, Feb;19(2):251-9

 

Héron B., Mikaeloff Y., Froissart R., Caridade G., Maire I., Caillaud C., Levade T., Chabrol B., Feillet F., Ogier H., Valayannopoulos V., Michelakakis H., Zafeiriou D., Lavery L., Wraith E., Danos O., Heard J.M., Tardieu M. (2011) Incidence and natural history of Mucopolysaccharidosis type III in France and comparison with United Kingdom and Greece. Am J Med Genet, 155:58-68

 

Lemonnier T., Blanchard S., Toli D., Roy E., Bigou S., Froissart R., Rouvet I., Vitry S., Heard J.M., Bohl D (2011). Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells. Hum Mol Genet 20:3653-66

Roy E, Bruyère J, Flamant P, Bigou S, Ausseil J, Vitry S, Heard JM. (2012) GM130 gain-of-function induces cell pathology in a model of lysosomal storage disease.Hum Mol Genet. 21:1481-95

 

David Digregorio / Dynamic Neuronal Imaging

 

Fink AE., Bender, KJ., Trussell, LO., Otis, TS. and DiGregorio, DA. Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor. PLoS One, 7(8):e41434(2012).

Abrahamsson, T., Cathala, L., Matsui, K., Shigemoto, R., and DiGregorio, DA. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron, 73: 1159-1172 (2012).

DiGregorio, D.A. Confocal spot detection of presynaptic Ca2+ domains. Optical Imaging in Neuroscience: A Laboratory Manual. Cold Spring Harbor Laboratory Press (in press).

 

Bradley, J., Luo, R., Otis, T.S. and DiGregorio, D.A. Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye. Journal of Neuroscience, 29(29):9197–9209 (2009).

 

Lutz, C, Otis, T, DeSars, V., Charpak S., DiGregorio, D. A., and Emiliani, V. Holographic photolysis of caged neurotransmitters. Nature Methods, 5(9):821-827 (2008).

 

DiGregorio, D.A., Rothman, J., Nielsen, T., and Silver, R.A. Desensitization Properties of AMPA Receptors at the Cerebellar Mossy Fiber–Granule Cell Synapse Journal of Neuroscience, 27(31):8344–8357 (2007).

 

Cathala, L., Holderith, N.B., Nusser, Z., DiGregorio, D.A., Cull-Candy, S.G. Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCs. Nature Neuroscience8(10):1310-8 (2005).

 

Nielsen, T., DiGregorio, D.A., Silver, R.A. Modulation of glutamate mobility reveals the mechanism underlying slow-rising AMPA receptor EPSCs and the diffusion coefficient in the synaptic cleft. Neuron, 42:757-771 (2004).

 

DiGregorio, D.A., Nusser, Z., Silver, R.A. Spillover of glutamate onto synaptic AMPA receptors enhances fast transmission at a cerebellar synapse. Neuron 35:512-533(2002).

 

DiGregorio, D.A., Peskoff, A., and Vergara, J.L. Measurement of action potential-induced presynaptic calcium domains at a cultured neuromuscular junction. Journal of Neuroscience, 19(18):7846-7859 (1999).

 

 Sheila Harroch (Unité faisant partir de l’Unité d’Uwe Maskos)

 

Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA. Harroch S, Revel M, Chebath J. EMBO J. 1994 Apr 15;13(8):1942-9.

A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.
Harroch S, Furtado GC, Brueck W, Rosenbluth J, Lafaille J, Chao M, Buxbaum JD, Schlessinger J.Nat Genet. 2002 Nov;32(3):411-4.

Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Okigaki M, Davis C, Falasca M, Harroch S, Felsenfeld DP, Sheetz MP, Schlessinger J. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19)

Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development.Lamprianou S, Vacaresse N, Suzuki Y, Meziane H, Buxbaum JD, Schlessinger J, Harroch S.
Mol Cell Biol. 2006 Jul;26(13):5106-19

Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene.
Buxbaum JD, Georgieva L, Young JJ, Plescia C, Kajiwara Y, Jiang Y, Moskvina V, Norton N, Peirce T, Williams H, Craddock NJ, Carroll L, Corfas G, Davis KL, Owen MJ, Harroch S, Sakurai T, O'Donovan MC. Mol Psychiatry. 2008 Feb;13(2):162-72.

A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Lamprianou S, Chatzopoulou E, Thomas JL, Bouyain S, Harroch S. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42): 17498-503.

Receptor-type tyrosine phosphatase ligands: looking for the needle in the haystack. Mohebiany AN, Nikolaienko RM, Bouyain S, Harroch S. FEBS J. 2012 Jun 11.

The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74.Cohen S, Shoshana OY, Zelman-Toister E, Maharshak N, Binsky-Ehrenreich I, Gordin M, Hazan-Halevy I, Herishanu Y, Shvidel L, Haran M, Leng L, Bucala R, Harroch S, Shachar I.J Immunol. 2012 Jan 1;188(1):259-69.

 Pleiotrophin is produced by the vascular niche and regulates hematopoietic stem cell self renewal and regeneration in vivo. H Himburg, JR Harris, P. Daher, J L Russell, M Quarmyne, P L Doan, K Helms, G Herradon, N J. Chao, S Harroch, JP Chute. Cell report in press

New insights into the roles of the contactin cell adhesion molecules in neural development. A N. Mohebiany, S Harroch and S. Bouyain. In press 2012

 

 

Christine Petit  Genetics & Physiology of Hearing

 

1. Sahly I, Dufour E, Schietroma C, Michel V, Bahloul A, Perfettini I, Pepermans E, Estivalet A, Carette D, Aghaie A, Ebermann I, Lelli A, Iribarne M, Hardelin J-P, Weil D, Sahel J-A, El-Amraoui A, Petit C (2012) Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice. J Cell Biol 199, 381-99.

 

2. Safieddine S, El-Amraoui A & Petit C (2012) The auditory hair cell ribbon synapse: from assembly to function. Annu Rev Neurosci 35, 509-28.

 

3. Caberlotto E, Michel V, Foucher I, Bahloul A, Goodyear RJ, Pepermans E, Michalski N, Perfettini I, Alegria-Prevot O, Chardenoux S, Do Cruzeiro M, Hardelin J-P, Richardson GP, Avan P, Weil D & Petit C (2011) Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc Natl Acad Sci USA 108, 5825-30.

 

4. Richardson GP, Boutet de Monvel J & Petit C (2011) How the genetics of deafness illuminates auditory physiology. Annu Rev Physiol 73, 311–34.

 

5. Bahloul A, Simmler M-C, Michel V, Leibovici M, Perfettini I, Roux I, Weil D, Nouaille S, Zuo J, Zadro C, Licastro D, Gasparini P, Avan P, Hardelin J-P & Petit C. (2009) Vezatin, an integral membrane protein of adherens junctions, is required for the sound-resilience of cochlear hair cells. EMBO Mol Med 1, 125-138.

 

6. Verpy E, Weil D, Leibovici M, Goodyear RJ, Hamard G, Houdon C, Lefèvre GM, Hardelin J-P, Richardson GP, Avan P & Petit C (2008) Stereocilin-deficient mice reveal the origin of cochlear waveform distortions Nature, 456, 255-258.

 

7. Delmaghani S, del Castillo FJ, Michel V, Leibovici M, Aghaie A, Ron U, Van Laer L, Ben-Tal N, Van Camp G, Weil D, Langa F, Lathrop M, Avan

P & Petit C (2006) Mutations in the gene encoding pejvakin, a novel protein expressed in the afferent auditory pathway, cause DFNB59 auditory neuropathy in man and mouse. Nature Genet 38, 770-778.

 

8. Roux I, Safieddine S, Nouvian R, Grati M, Simmler M-C, Bahloul A, Perfettini I, Le Gall M, Rostaing P, Hamard G, Triller A, Avan P, Moser T & Petit C (2006) Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell 127, 277-289.

 

9. Soussi-Yanicostas N, de Castro F, Julliard AK, Perfettini I, Chédotal A & Petit C (2002) Anosmin-1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons. Cell 109, 217-228..

 

10. Weil D, Blanchard S, Kaplan J, Guilford P, Gibson F, Walsh J, Mburu P, Varela A, Levilliers J, Weston MD, Kelley PM, Kimberling WJ, Wagenaar M, Levi-Acobas F, Larget-Piet D, Munnich A, Steel KP, Brown SDM & Petit C (1995) Defective myosin VIIA gene responsible for Usher syndrome type 1B. Nature 374, 60-61.

 

Pierre-Marie LLEDO / Perception and Memory

 

  1. Alonso M, Wagner S, Lepousez G, Gabellec MM, Torquet N et Lledo P-M. Activation of adult-born neurons facilitates learning and memory. Nat. Neurosci. 15, 897-904, 2012 (selected for Faculty of 1000 Biology).
  2. Nissant A, Bardy C, Katagiri H, Murray K et Lledo P-M. Neurogenesis promotes synaptic plasticity in the adult olfactory bulb. Nat. Neurosci. 12, 728-730, 2009 (selected for Faculty of 1000 Biology).
  3. Lagier S, Panzanelli P, Russo R, Sassoè-Pognetto M, Fritschy JM et Lledo P-M. GABAergic inhibition at dendro-dendritic synapses tunes gamma oscillations in the olfactory bulb. Proc. Natl. Acad. Sci. 104, 7259-64, 2007.
  4. Hack M, Saghatelyan A, De Chevigny A, Lledo P-M et Götz M. Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat. Neurosci. 8, 865-872, 2005.
  5. Saghatelyan A, Roux P, Migliore M, Rochefort C,Charneau P, Shepherd G et Lledo P-M. Activity-dependent adjustments of the inhibitory network in the adult olfactory bulb following early postnatal deprivation. Neuron 46, 103-116, 2005.
  6. Saghatelyan A, De Chevigny A, Schachner M et Lledo P-M. Tenascin-R fosters radial migration of neuroblasts in the adult forebrain. Nat. Neurosci. 7, 347-356, 2004.
  7.  Carleton A, Petreanu L, Lansford R, Alvarez-Buylla A et Lledo P-M. Becoming a new neuron in the adult olfactory bulb. Nat. Neurosci. 6, 507-518, 2003.
  8. Lledo P-M, Zhang S, Südhof T, Malenka RC et Nicoll RA. Postsynaptic membrane fusion and long term potentiation. Science 279, 399-403, 1998.
  9. Lledo P-M, Vernier P, Vincent J-D, Mason WT et Zorec R. Inhibition of Rab3b expression attenuates calcium-dependent exocytosis in rat anterior pituitary cells. Nature (London) 364, 540-544, 1993.
  10. Lledo P-M, Homburger V, Bockaert J et Vincent J-D. Differential G protein-mediated coupling of D2 dopamine receptors to K+ and Ca2+ currents in rat anterior pituitary cells. Neuron 8, 455-463, 1992.

 

Jean-Pierre Corringer / Channel Receptors

 

Prevost, M., Sauguet, L., Nury H., Van Renterghem, C., Huon, C., Poitevin, F., Baaden, M., Delarue, M.*, Corringer, P.J.* a novel locally-closed conformation of a bacterial pentameric proton-gated ion channel, Nat Struct Mol Biol. 19:642-9 (2012) (Ranked 8 by Faculty of 1000)

 

Corringer P.J.*, Poitevin F, Prevost MS, Sauguet L, Delarue M, Changeux JP*. Structure and pharmacology of pentameric receptor channels: from bacteria to brain Structure. ;20(6):941-56. (2012)

 

Duret, C., Van Renterghem, C, Weng, Y, Prevost, M., Moraga, G., Huon, C., Sonner, J.M., Corringer P.J.* A functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family, Proc Natl Acad Sci U S A. 108:12143-8 (2011) (Ranked 10 by Faculty of 1000)

 

Nury, H, Van Renterghem, C, Weng, Y, Tran, A, Baaden, M, Dufresne, V, Changeux, J.P., Sonner, J.M., Delarue, M*, Corringer, P.J.* X-ray structures of general anesthetics bound to a pentameric ligand-gated ion channel Nature, 469:428-31 (2011) (Ranked 17 by Faculty of 1000)

 

Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer P.J., Delarue M.* Crystal Structure of the Extracellular Domain of a Bacterial Ligand-Gated Ion Channel. J Mol Biol. 395, 1114–1127 (2010)

 

Corringer, P.J.*, Baaden, M., Bocquet, N., Delarue, M., Dufresne, V., Nury, H., Prevost, M., Van Renterghem, C., Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues, J. Physiol, 588(Pt 4):565-72 (2010)

 

Bocquet, N., Nury, H., Baaden, M., Le Poupon, C., Changeux, J.P., Delarue, M.*, Corringer, P.J.* X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation, Nature, 457(7225) :111-4 (2009) (Ranked 14 by Faculty of 1000)

 

Bocquet, N., Prado de Carvalho, L., Cartaud, J., Neyton, J., Le Poupon, C., Taly, A., Grutter, T., Changeux, J.P., Corringer, P.J.* A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family, Nature, 445: 116-119 (2007)

 

Sallette, J.,Pons, S., Devillers-Thiery A., Soudant, M., Prado de Carvalho, L., Changeux J.P.* and Corringer, P.J.*, Nicotine up-regulates its own receptors through enhanced intracellular maturation, Neuron, 46:595-607 (2005) (Ranked 8 by Faculty of 1000)

 

Mis à jour le 14/01/2014

Agenda

Tout l'agenda

Emplois

Consultez les offres d'emplois à l'Institut Pasteur