Post-doctoral position on developmental biology of the heart

Post-doc position

 

IN HEART DEVELOPMENT

 

 

A post-doctoral position, funded by the Institut Pasteur and Institut Imagine, is available in the newly established group of Heart Morphogenesis of Sigolène Meilhac, to study the cellular mechanisms of heart looping.

 

A restricted repertoire of cell behaviour underlies morphogenesis. How local cell behaviour is coordinated and how different aspects of cell behaviour are combined to generate global shape changes are current questions in developmental biology. Using the heart as a model of morphogenesis in 3D, we have shown with interdisciplinary tools for quantitative image analysis that myocardial cells coordinate their orientations of division (Le Garrec et al., 2013). More recently our work focussed on the regulation of cell coordination by the atypical cadherin Fat4 during heart growth.

 

Looping of the heart tube provides a striking example of a 3D shape change, which is essential to align cardiac chambers and establish the double blood circulation. The direction of heart looping depends on the establishment of left-right patterning in the embryo. However, the cellular mechanisms underlying this are poorly understood. The aim of the project is to gain insight into the cellular mechanisms of heart looping, using approaches of embryology, cell biology, mouse genetics and computer modelling. A novel mouse model of heart looping defects will be developped and analysed.

 

This project is relevant to congenital heart diseases in humans resulting from a misalignment of cardiac chambers. This will be explored on campus, in collaboration with the cardiopediatricians of the Hospital Necker Enfants-Malades.

 

The position is funded for 3 years and is available immediately.

 

Highly motivated candidates are encouraged to postulate. A sound background in Developmental or Cell Biology is essential. Applications, including a covering letter, a curriculum vitae and contact details of three references should be sent to :

 

Sigolène Meilhac, Ph.D.

sigolene.meilhac@pasteur.fr

 

 

The Institut Pasteur and Institut Imagine, located in the vibrant city of Paris, provide an excellent research infrastructure including state-of-the-art core facilities in developmental biology and genetics and support structures. This international and interdisciplinary environment offers competitive training and career opportunities.

Mis à jour le 24/03/2015

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