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This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal.
This course offers a full traing program for advanced graduate and PhD students, as well as post graduate biologists and medical doctors willing to work on medical and experimental Mammalian Genetics.
The theoretical part of this course deals, in particular, with the early embryo biology, pluripotent stem cells, cellular and molecular mechanisms controling embryogenesis and methods to study cell lineage in mouse embryos, gene inactivation and conditional expression systems for transgenes, the role of small RNAs, and genetic analysis of mendelian and complex traits.
The practical part presents methods and techniques used to derive induced pluripotent stem cells (iPS) from differentiated cells, to study behavioral traits and to analyze gene function in embryonic and adult mutants, to map mendelian traits and perform positional cloning, and to identify QTLs. They illustrate the use of RNA interference to silence gene expression.
The program of the course organized the previous year can be downloaded to get detailed information on the general frame of the course; some topics and practical works may change each year, without altering the general aims means of the course.
Student opinion on the Mouse Genetics Course
According to recent opinion surveys, 100% of the students felt that the course fulfilled their expectation, covers the topic, and offers very good or excellent lectures. The general organization and the program were qualified as very good or excellent by all attendees. From free comments: "Effective teaching through an exchange with the students by an active teaching staff. All this orchestrated by very receptive and well recognized experts", "I really enjoyed the course despite the very busy days of study", "A very big thank for this incredibly rich training", "I really appreciated the quality of lectures and practical trainings. I will recommend this course to other students".
Candidates must have a good knowledge of basic laboratory techniques at the Master degree level. The committee of the course will evaluate applications.
Members of the Teaching Committee :
A. Lalouette* (Université Paris-Diderot),
E. Coeffier (Institut Pasteur),
X. Montagutelli (Institut Pasteur),
M. Sala (Institut Pasteur),
H. Waxin (Institut Pasteur),
J.-J. Panthier* (Institut Pasteur, Ecole Nationale Vétérinaire d’Alfort),
B. Robert (Institut Pasteur),
M. Cohen-Tannoudji (Institut Pasteur),
J. Artus* (Université Paris Saclay),
F. Toledo*(Université P. et M. Curie).
* University Representatives
|Title of the course||Mouse genetics|
Mouse Fonctional Genetics Unit,
Mouse Fonctional Genetics Unit,
CNRS UMR 7102,
Alfort Veterinary Medical School
|Head of studies||
Mouse Functional Genetics Unit
CNRS, URA 2578
January 9 - February 14, 2017 (exam included)
|Closing date for application||
September 9, 2016
Institut Pasteur Diploma
Diplôme d'Université (DU) from University Paris Diderot for people registering at this university (registration fees ≈ 250 €).
Credits for a master degree for students registered at partner universities.
Attending conferences can be validated as "module d'école doctorale" for students registered at partner universities.