Innate Immunity

Head of Unit: James DI SANTO


The Innate Immunity Unit comprises 16 members (4 permanent scientists, 4 engineers/technicians, 5 postdoctoral fellows, 3 PhD students) with complementary interests and expertise in immunology, developmental biology, virology and animal models.




Together with the Lymphopoiesis Unit (Ana Cumano) and Dynamics of Immune Response Unit (Philippe Bousso), we form the Inserm Unit 668 (Pathophysiology of the Immune System) that pursues collaborative projects involving lymphocyte development, differentiation and functional dynamics.


Innate Immunity Unit
Inserm U668
Institut Pasteur
25 rue du Docteur Roux
75724 Paris Cedex 15
Tel. +33 1 45 68 82 09
Secretary +33 1 45 68 86 96
Fax + 33 1 40 61 35 10
Our lab is located on the 4th Floor of the Metchnikoff Building (building N° 67 on the map below).



Nicolas Serafini, Christian Vosshenrich and James Di Santo published a new review on ILC development in Nature Reviews Immunology: Transcriptional regulation of innate lymphoid cell fate. Nature Reviews Immunology 15:415-428     


Nicolas Serafini obtained an Inserm permanent position.


Wei Xu published her work on Nfil3 in ILC precursor formation. 

Xu, W., Domingues, R.G., Fonseca-Pereira, D., Ferreira, M., Ribeiro, H., Lopez-Lastra, S., Motomura, Y., Moreira-Santos, L., Bihl, F., Braud, V.M., Kee, B., Brady, H., Coles, M.C., Vosshenrich, C.A.J., Kubo, M., Di Santo, J.P. and Veiga-Fernandes, H. (2015) NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Reports 10:2043-2054. 


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