The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over ...
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial ...
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study ...
Without going into more thorough analysis of this question, we can state that the white corpuscles are microscopic organisms that are more complex than they appear at first sight and that to deal with them in the mass to make extracts is almost as rough a method as squeezing whole animals, say mice or frogs, to find out their digestive powers. Elie Metchnikoff, 1908
Director, Department of Immunology
Since its discovery, researchers at the Institut Pasteur have been enthralled by the beauty inherent in the host immune system. And over 100 years later, researchers remain humbled by its complexity. The Department of Immunology, which includes 14 research units and 2 technical platforms composed of 166 scientists, has a shared interest in exploring the fundamental processes of immunity with the hope to provide new insight into disease pathogenesis, inspire novel vaccines and design unique therapeutic strategies. Moreover, the scientists of the Department share a commitment to training the next generation of scientists dedicated to research excellence in the field of immunology.
Research conducted in the Department is organized into three main themes.
Development of the immune system.
From the earliest hematopoietic precursors which appear in the yolk sac to the organization of lymphoid tissues, the competition for unique niche and resources that define the immune repertoire and the mechanisms that ensure homeostasis – the development of the immune system is intricately linked to our relationship with commensal organisms and its ability to respond to infectious agents and malignant transformation. Research units headed by Ana Cumano, James DiSanto, Gerard Eberl, Ludovic Deriano and Antonio Freitas are helping to advance our understanding in these areas.
Innate and adaptive immune responses.
Spanning from cell trafficking, proliferation and differentiation during host response to the signaling pathways that regulate these processes – the understanding of how the innate and adaptive immune responses function requires a coordinated effort employing cutting-edge biochemical, imaging and cell physiology approaches. Research units headed by Andres Alcover, Philippe Bousso, Pierre Bruhns, Caroline Demangel and Sandra Pellegrini have been providing critical information into the cross-talk between the two arms of our immune system, as well as the mechanism by which micro-organisms subvert the host response for their own benefit.
Immune pathology and Immunotherapy.
The immune response is often referred to as a double-edged sword, pathogenic in the case of chronic infection and autoimmunity but protective in their control of cells undergoing malignant transformation or in the case of vaccination. Research units headed by Matthew Albert, Claude Leclerc, Hugo Mouquet and Lars Rogge investigate the regulation of immunity in disease with the aim to translate their research into new diagnostic and therapeutic modalities. The researchers within the department are highly collaborative, with their programs not only cutting across the stated thematic areas, but also forging important links to virology, bacteriology, parasitology, cell biology, genetics, developmental biology and epidemiology.
In addition to the Research Units, the Department hosts two core platforms: The Cytometry Platform and The Center for Human Immunology, both part of the Imagopole network, headed by Spencer Shorte. Both structures provide researchers access to cutting-edge technologies with opportunities to participate in training courses as well as user groups in order to optimally meet the needs of the scientific community.
As part of a century-long commitment to understanding host immunity, the Department has taken the lead in training the future generations of immunologists. Notably, members of the department organize what is considered the top Immunology Masters course in France, attracting students from all over the world, who benefit from lectures in fundamental and applied immunology. Research Units within the department also welcome masters, graduate and post-doctoral students. Currently there are 34 students, at different stages of their training.
Following links on this web site, you will explore the different activities ongoing within the Department of Immunology, as well as the Institute Pasteur and our surroundings. You will also find a calendar of seminars and events, a link to the Immunology Course and a full list of training opportunities offered by the Institute. We also direct you to the profiles of faculty interests and recent literature citations, descriptions of our facilities and a section providing information on departmental policies and procedures.
The Department of Immunology would like to thank its generous sponsors, whose support enables to maintain a robust academic environment within the department.