Developmental & Stem Cell Biology

The work conducted by the Developmental Biology Department covers a broad spectrum of multidisciplinary research that focuses on everything from individual cells to the organism as a whole. This includes several projects on the study of stem cells and their potential in biomedicine.

 

 

 

The aim of the Developmental Biology Department is to understand how a highly integrated multicellular organism such as a human being develops from a single cell, the fertilized egg.

 

Four main research objectives have been defined:

 

  • identify embryo cell movements and migrations that are required for organ and tissue formation and the information exchanges used during this process;
  • determine how the identity of each cell is established and maintained through specific programming mechanisms;
  • establish the role of stem cells, which play a dominant part not only in embryogenesis but also in the regulation and maintenance mechanisms of adult tissues;
  • clarify the respective roles of innate and non-genetic factors in the phenotype developed by the individual, and their genetic contributions to the host’s resistance to infectious diseases and/or congenital and metabolic diseases.

 

The Department successively submitted the REVIVE laboratories of excellence (LabEx)  project to the French government’s prestigious Investing in the Future program. The ten-year funding obtained will make possible the development and coordination of this key project which aims to build a world class network of stem cell experts from the Institut Pasteur and Paris region that will ultimately become a globally recognized hub for regenerative medicine.

 

Heads of lab at Institut Pasteur

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