The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over ...
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial ...
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study ...
Developmental biology first made its appearance in the Pasteur Institute when François Jacob and François Gros with their colleagues became interested in extending their pioneering work on messenger RNA in bacteria to gene regulation in eukaryotic systems.
Director for the DSBD
This led to the introduction of mouse genetics and embryology and to work on differentiating cells in culture.
Initially these and other research groups were part of the Molecular Biology Department in the Jacques Monod building, which opened at the end of the 1960s, after the award of the Nobel prize to Jacob, Monod and Lwoff.
Scientific research and communal activities
The Department of Developmental Biology was created in 2001, and includes the descendants of the original laboratories in the Jacques Monod building, as well as others which have joined the Institute. Today research in the Department converges on two main poles of interest.
One concerns the regulation of gene expression in different developmental contexts, ranging from molecular studies on transcription factors and chromatin structure to the analysis of phenotypes when regulatory genes are mutated. The other focusses on cell lineages and cell behaviour in the embryo, with an interest also in the progenitor cells of adult tissues.
In a biomedical context, with an interface with other departments on the campus, these developmental studies have led to work on stem cells with a potential for tissue regeneration and to the creation of a number of mouse models for human disease.
The Department has a strong tradition in genetics, both in classical genetics and in gene manipulation in the mouse. This is reflected by the presence of veterinarians responsible for the mouse facilities of the Institute, and the transgenic mouse service, which is also attached to our Department.
Our colleagues also include human geneticists and a group using Drosophila genetics. The mouse is the model organism studied by most laboratories. However, in addition to Drosophila, there are groups working with zebra fish, and the chick embryo is also used. Precise information about research activities is given under each Unit or Group.
Research units in the DSCB Department have published over 250 research articles and over 70 reviews in the last 5 years (Cell, Cell Stem Cell, Developmental Cell, Cell Host Microbe, N Engl J Med, Nature, Nature Medicine, Nature Cell Biology, Nature Struc. Mol. Biology, Nature Communications, Nature Methods, Nature Protocols, Science, Science Signaling, J. Exp. Medicine, Genes & Development, Blood, PNAS, EMBO J, PloS Biology, Development)
Recent distinctions include:
Philip Avner, Director EMBL Monterotondo, Italy
Margaret Buckingham, CNRS Gold Medal
Margaret Buckingham, Foreign member of Royal Society of UK
Margaret Buckingham, Foreign member of Nat. Adac. Sci. of USA
Anu Bashamboo, the International Royan Award for Reproductive Genetics
Jerôme Gros, Paoletti prize
Ken McElreavey, French National Academy of Medicine prize
François Schweisguth, EMBO member
François Schweisguth, Zermati prize, Fondation de France
Shahragim Tajbakhsh, EMBO member
Shahragim Tajbakhsh, Vallery Radot prize
Shahragim Tajbakhsh, Academy of Sciences/Fondation de France prize for research on stem cells
ERC starting Grant: Jerôme Gros
ERC advanced grant: Shahragim Tajbakhsh
PIs emerging from the DSCB Department
Several senior researchers obtained independent group leader positions since 2009:
Marco Pontoglio (2009) - Group Leader, Institut Cochin, Paris
Allison Bardin (2010) - Group Leader, (CNRS ATIP- Avenir), Institut Cochin, Paris
Ramkumar Sambasivan (2012) - Group Leader, inStem, Bangalore, India
Colin Crist (2013) - Assistant Professor, McGill University, Canada
Karima Kissa (2013) - Group leader (CNRS ATIP-Avenir), University of Montpellier
Milka Sarris (2014) - MRC Research Fellow, University of Cambridge, UK
Ute Rogner (2014) - Group Leader, Institut Cochin, Paris
Sigolène Meilhac (2014) - Group Leader, Institut Pasteur/Necker Hospital, Paris