Biology of Host-Parasite Interactions

 
 
The Biology of Host-Parasite Interactions unit (Biologie des interactions hôte-parasite / BIHP) studies the parasite that causes the most serious form of human malaria, Plasmodium falciparum.
 

The research activities of the different groups in the lab are mostly based on the red blood cell stage of Plasmodium falciparum's life cycle that is responsible for clinical symptoms.

 

One of our major research interests is the investigation of virulence factors associated with malaria pathogenesis (using a P. berghei model / group of Salah Mécheri) and the molecular basis of immune escape strategies (antigenic variation).

 

These focus areas encompass the transport of virulence factors to the surface of the erythrocyte via specialised trafficking mechanisms.

 

Another line of research is the study of the biological role of nuclear architecture. For more details, please click on the "Research" link.

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Malaria parasites (Plasmodium falciparum) in human red blood cells

 

 

Our unit is a member of the Inserm U1201 unit, as well as a CNRS "Equipe de recherche labellisée" (ERL 9195).  It is also a member of the French Network of Excellence on Parasitology (LabEx) ParaFrap whose scientific directors are Frédéric Bringaud, Artur Scherf and Stan Tomavo.

 

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Contact

Biology of Host Parasite Interactions Unit
Institut Pasteur
25 rue du Docteur Roux
75724 Paris cedex 15
France

tel. +33 1 45 68 86 16 (Artur SCHERF)
tel. +33 1 45 68 86 27 (secretary)
fax. +33 1 45 68 83 48

The lab is located on the second floor of the Nicolle Buidling (n°65 on the Map of Institut Pasteur)

 

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