The emergence and spread of bacteria resistant to many drug classes seriously threaten all branches of modern medicine. There is currently no course providing advanced instruction on antibiotics and resistance. The specific goal of ICARe is to bring leaders in academics and industry together with trained scientists at the dawn of their careers. Cutting-edge approaches for detection of resistance and antibiotic discovery, chemical optimization, and usage that minimizes the developement of resistance will be examined.
The objective of the course is to train the next generation of scientists implicated in the study of bacterial resistance to antibiotics and the finding of new drugs
The faculty is composed of 40 internationally recognized scientists and physicians who have made important contributions to antibiotic development, and infectious diseases and resistance management. Faculty will be in residence for a minimum of two days and accessible for informal interactions. Graduates will emerge with a state-of-the-art understanding of existing antibiotics: modes of action, pharmacology, toxicology, mechanisms of resistance, impact of antibiotics on human and other ecologies, current approaches for mining chemical space for antimicrobial activity, the process of advancing hits to leads, the application of next generation nucleic acid-based technologies for antibiotic discovery and resistance detection, and perhaps, most importantly, training and experience in thinking creatively and innovatively about solutions to the problem. The course aims to build an international cadre of collaborative, well networked, and highly trained specialists.
THE THEMES OF THE CONFERENCES
- Current infectious disease management and antibiotic use
- Modes of action and mechanisms of resistance of existing classes : Cell wall, Ribosome, Nucleic acid synthesis / replication / transcription, Efflux
- Origin, mutations, and identifications of antibiotic resistance mechanisms
- Antibiotic discovery
- Antibiotic chemical matter : Natural products, synthetics
- Antibiotic development and approval
- New topics in antibiotic discovery
- Strategies for more focused applications of antibiotics
- New technologies for determination of susceptibility and detection of resistance
- New antiinfective strategies
THE THEMES OF THE PRACTICAL WORK
- Choosing the DNA sequencing technology
- Data bases for antibiotic resistance and virulence
- Detection and identification of resistance genes
- Mobile genetic elements
- TnSeq, RNASeq
- Functional genomics
The course will be administered over 8 days and will consist of formal instruction, review of the literature, small group problem solving including hands-on use of relevant computational tools, innovation-driven brainstorming sessions, and network building.
ICARe is designed for early career scientists - assistant professors, new industry scientists, MDs, and postdoctoral research associates - as well as members from developing areas contending with the practical challenge of managing the antibiotic resistance problem with limited resources. Attendance will be limited to 40 students and will reflect the global nature of the problem.