P10.1 Cyclopropane mycolic acid synthases, etc P10.2 Various semialdehyde dehydrogenases P10.3 ECF subfamily sigma subunits P11.1 Sensor histidine kinases P11.2 Acetyl-CoA C-acetyltransferases, lipid carrier proteins P11.3 Probable esterases, penicillin binding proteins P11.4 UNK P12.1 Cation-transporting ATPase P13.1 UNK P14.1 ESAT-6 family P14.2 UNK P14.3 UNK P14.4 Dehydrogenases P15.1 UNK P15.2 UNK P16.1 MmpL family P16.2 13E12 repeat family P16.3 Sugar transporters P16.4 UNK P17.1 N-terminal part of IS6110 transposase P17.2 Transcriptional regulator (mostly ArsR family) P18.1 Putative oxidoreductases P18.2 C-terminal part of IS6110 transposase P2.1 MutT homologs (mutT1) P2.10 ODD P2.100 Transcriptional regulators (PbsX/Xre family) P2.101 UNK P2.102 Inteins in dnaB/recA P2.103 UNK P2.104 TrkA/TrkB P2.105 ODD P2.106 phiRV2/phiRV1 phage related proteins P2.107 phiRV2/phiRV1 phage related proteins P2.108 phiRV2/phiRV1 phage prohead protease P2.109 phiRV2/phiRV1 phage related proteins P2.11 lipoproteins, lppO, lpqH P2.110 dedA, Rv0364 P2.111 UNK P2.112 UNK P2.113 ODD P2.114 Possibe transcriptional regulators P2.115 Thioesterases P2.116 UNK P2.117 UNK P2.118 Peptidyl-prolyl cis-trans isomerases P2.119 Transmembrane proteins, possibly ABC transporter subunits P2.12 ODD P2.120 UNK P2.121 UNK P2.122 Dehydrogenases P2.123 Probable glycerol-3-phosphate acyltransferases P2.124 ODD P2.125 Probable glycosyl hydrolases P2.126 Hemoglobin-like proteins P2.127 ATP-dependent ClpP proteases P2.128 UNK, possible ATP-binding proteins P2.129 UNK P2.13 Probable proline permeases P2.130 Probable transposases e.g. IS1558 P2.131 Gamma-glutamyl transpeptidases P2.132 UNK P2.133 Cysteine/sulfur metabolism P2.134 Exported proteins P2.135 DnaJ homologues P2.136 PhoH-like proteins P2.137 UNK P2.138 Ferric uptake regulatory proteins P2.139 UNK possibly transcriptional regulators P2.14 Possible deaminases P2.140 UNK P2.141 Transcriptional regulators (LysR family) P2.142 Pit phosphate permeases P2.143 Efflux proteins P2.144 Integral membrane proteins P2.145 Probable membrane protein P2.146 MurC, MurF P2.147 FtsW-like membrane proteins P2.148 DNA polymerase(s) I P2.149 RpsN 30S ribosomal proteins (S14) P2.15 Excisionases P2.150 RpsR 30S ribosomal proteins (S18) P2.151 UNK P2.152 UNK P2.153 Heat shock proteins (Hsp20 family) P2.154 UNK P2.155 UNK P2.156 Possible rRNA methyltransferases P2.157 Membrane proteins, LysE/YggA family P2.158 GTP cyclohydrolases P2.159 UNK P2.16 DNA polymerase(s) III P2.160 UNK P2.161 Exported proteins P2.162 UNK P2.163 L-lactate dehydrogenases P2.164 UNK P2.165 Exported proteins P2.166 Exported proteins P2.167 ODD P2.168 Carbamoyltransferases P2.169 BioF-like proteins P2.17 UNK P2.170 UNK P2.171 UNK P2.172 Probable rhamnosyl/glycosyl transferases P2.173 Probable glycosyltransferases P2.174 Methylmalonyl-CoA mutase subunits P2.175 Probable membrane proteins P2.176 UNK P2.177 Glucose-6-phosphate 1-dehydrogenases P2.178 Probable transporters P2.179 ODD P2.18 Penicillin-bonding proteins (class A) P2.180 UNK, possibly YegE/YhjK/YjcC members P2.181 UNK P2.182 ATP synthase subunits P2.183 ATP synthase subunits P2.184 IlvA/ThrC P2.185 GMC-type oxidoreductases P2.186 ODD P2.187 Membrane (lipo)proteins P2.188 YfiO-like proteins P2.189 LmbE-like proteins P2.19 (Oligo)peptide transport proteins P2.190 Transposase e.g. IS-"like" P2.191 Transposase e.g. IS-"like" P2.192 Transcriptional regulator (PbsX/Xre family) P2.193 Acyl-[ACP] desaturases P2.194 Serine hydroxymethyltransferases P2.195 UNK P2.196 MoeA molybdopterin biosynthesis proteins P2.197 Membrane proteins P2.198 Probable dioxygenases P2.199 UNK P2.2 UNK P2.20 (Oligo)peptide transporters P2.200 UNK P2.201 UNK P2.202 Peptidase, protease P2.203 UNK, possibly lipases P2.204 Carbohydrate kinases P2.205 ODD P2.206 Membrane proteins P2.207 ODD P2.208 Possible glycosyltransferase P2.209 UNK P2.21 ATP-dependent helicase domain P2.210 UNK P2.211 ODD P2.212 ODD P2.213 Transcriptional regulators (GntR family) P2.214 Putative oxidoreductases P2.215 UNK P2.22 Cold shock proteins P2.23 UNK P2.24 Probable membrane proteins P2.25 ODD P2.26 Cysteinyl-tRNA synthases P2.27 4-hydroxy-2-oxovalerate aldolase(s) P2.28 UNK P2.29 ODD P2.3 UNK P2.30 Similar to macrotetrolide resistance proteins P2.31 Envelope (lipo)proteins P2.32 ODD P2.33 Membrane proteins P2.34 GroEL chaperonins P2.35 Inosine-5'-monophosphate dehydrogenases P2.36 ODD P2.37 UNK P2.38 LytB protein homologues P2.39 Probable transketolases P2.4 UNK P2.40 DNA polymerase III a chains P2.41 Dienoyl-CoA Reductase(s) P2.42 UNK, possibly membrane proteins P2.43 Probable penicillin binding proteins P2.44 Molybdopterin-converting factors P2.45 Phosphorylases P2.46 Glycerol-3-phosphate dehydrogenases P2.47 Lipoproteins probably esterases P2.48 Rubredoxins P2.49 SecA, preprotein translocases P2.5 UNK P2.50 ODD P2.51 Phosphoglycerate mutases P2.52 ATP-dependent DNA/RNA helicases P2.53 MmpS3-like proteins P2.54 Probable ABC transporters P2.55 Probable integral membrane proteins P2.56 UNK P2.57 Membrane proteins P2.58 Oxidoreductase subunits P2.59 ODD P2.6 UNK P2.60 Sensor histidine kinases P2.61 Thiosulfate sulfurtransferases P2.62 MoaA molybdenum cofactor biosynthesis protein A P2.63 Peptide chain release factors P2.64 UNK, possibly transcriptional regulators P2.65 Citrate lyase b chain and related protein P2.66 UNK P2.67 UNK P2.68 Probable DNA-damage-inducible proteins P2.69 Ribonucleotide reductases large subunits P2.7 Transposase e.g. IS1608 P2.70 Ribonucleotide reductase small subunits P2.71 UNK P2.72 Secreted immunogenic proteins e.g. mpt64 P2.73 Outliers of the PE family P2.74 Lipoproteins P2.75 D-3-phosphoglycerate dehydrogenase(s) P2.76 ODD P2.77 ODD P2.78 GpdA glycerol-3-phosphate dehydrogenases P2.79 Purine synthetic enzymes P2.8 Bacterioferritins P2.80 Possible glycosyltransferases P2.81 UNK P2.82 UNK P2.83 Similar daunorubicin resistance transmembrane proteins P2.84 SRP/cell division proteins P2.85 UNK P2.86 Secreted immunogenic proteins Mpt70/Mpt83 P2.87 UNK P2.88 ODD P2.89 Sugar transporters (lipoproteins) P2.9 ODD P2.90 UNK P2.91 ODD P2.92 UNK P2.93 Iron dependent repressors, IdeR/SirR P2.94 Dehydrogenases P2.95 UNK P2.96 UNK P2.97 HsdS-like determinants P2.98 UNK P2.99 CDP-diacylglycerol-glycerol-3-phosphate phosphatidyltransferases P20.1 Cytochrome P450 family P24.1 Mce family P27.1 Enoyl-CoA hydratases P208.1 Various proteins involved in lipid metabolism, etc P210.1 PE, PPE, etc P3.1 Transposases. e.g. IS1557 P3.10 Methionine biosynthesis MetB, MetC, MetZ P3.11 Transposase e.g. IS1547 + 1 ODD P3.12 MoaC molybdenum cofactor biosynthetic proteins P3.13 Iron sulphur protein subunits of flavoenzymes P3.14 Transcriptional regulators (Lrp/AsnC family) P3.15 RNA polymerase sigma factors P3.16 UNK, some similarity to HSP, P3.17 Putative transcriptional regulators P3.18 Unknown ATP-binding proteins P3.19 UNK, P3.2 ODD P3.20 Probable monophosphatases P3.21 UNK P3.22 Probable glycosyltransferases P3.23 Transposases e.g. IS1534 P3.24 Penicillin-binding proteins P3.25 Enzymes with uroporphyrin-III c-methyltranse signature P3.26 UNK P3.27 UNK P3.28 ODD P3.29 Lipoproteins P3.3 EmbA,B,C arabinogalactan synthesis P3.30 Probable arsenical pumps P3.31 Probable exported proteases P3.32 UNK P3.33 ODD P3.34 SucA, SucB, PdhC P3.35 ODD P3.36 Similar to phosphoglycerate mutases P3.37 Membrane proteins P3.38 Acyl carrier proteins e.g. AcpM P3.39 PolC, UvrC, etc. P3.4 UNK P3.40 UNK P3.41 ODD P3.42 UNK P3.43 Reductases, nitrite, etc. P3.44 Membrane proteins P3.45 (NADH) dehydrogenases P3.46 Polyketide synthases (chalcone synthase-like) P3.47 Similar to adenylate cyclases P3.48 phiRV1/phiRV2 phage proteins P3.49 Maltodextrin-modifying enzymes P3.5 Transcriptional regulators (AraC family) P3.50 UNK P3.51 Transmembrane proteins P3.52 NifS family members P3.53 Possible transport proteins P3.54 HIT family members P3.55 Citrate synthases P3.56 ATP-dependent DNA helicases (RecG, Mfd, UvrB) P3.57 PstS components of phosphate uptake system P3.58 Membrane proteins P3.59 Putative transcriptional regulators P3.6 IS-encoded proteins e.g. IS1533 P3.60 UNK P3.61 UNK P3.62 Isocitrate lyases P3.63 Probable methyltransferases P3.64 UNK P3.65 Oxidoreductase subunits e.g. NADH dehydrogenase P3.66 UNK P3.67 50S ribosomal protein L28 + 1 ODD P3.68 Possible transcriptional regulators P3.69 Probable coiled-coil proteins, includes ag84. P3.7 ATPase of AAA-family, FtsH P3.70 UNK P3.71 Probable oxidoreductases P3.72 Probable exported (lipo)proteins P3.8 Probable ferredoxins P3.9 Probable phosphoglucomutase or phosphomannomutases P31.1 Transcriptional regulator (LuxR), two-component response regulators P36.1 Acyl-CoA dehydrogenases P4.1 MoxR transcriptional regulators P4.10 Various (amino)peptidases P4.11 tRNA synthases (I, L, M, V) P4.12 Probable (rRNA) methyltransferases P4.13 Various dehydrogenases, e.g. phosphogluconate dehydrogenase P4.14 UNK P4.15 ODD P4.16 CpsA-related proteins P4.17 PKS-associated proteins P4.18 Probable methyl transferases P4.19 UNK P4.2 MmpS conserved small mycobacterial membrane proteins P4.20 WhiB transcriptional activators P4.21 UNK P4.22 Thiosulfate sulfurtransferases P4.23 Various acyl-CoA racemases P4.24 Lipoproteins P4.25 Probable DNA glycosylases, endonucleases P4.26 Glutamine synthases P4.27 Phospholipase C precursors P4.28 UNK P4.29 UNK P4.3 Probable nitrite extrusion proteins P4.30 Possible trehalose-6-phosphate phosphatases + 2 ODD P4.31 UNK P4.32 Possible chromosomome segregation proteins (Soj) P4.33 Various tRNA synthases, e.g. lysyl-tRNA synthase P4.34 Various synthase components e.g. anthranilate, p-aminobenzoate, etc. P4.4 Probable dehydrogenases P4.5 Probable Clp protease subunits + 1 ODD P4.6 Probable monooxygenase component + 1 ODD P4.7 Various transporters, possible sulphate + 1 ODD P4.8 UNK transcriptional regulator (IclR family) + 1 ODD P4.9 UNK P41.1 UNK transcriptional regulators (mainly TetR family) P5.1 Various cysteine synthase subunits P5.10 Various heptaprenyl and geranylgeranyl pyrophosphate synthases P5.11 Various dihydrolipoamide dehydrogenases P5.12 Acetyl/propionyl CoA carboxylase a subunit P5.13 ATP-dependent DNA helicases (UvrD, etc.) P5.14 Hydrophobic subunit of oxidoreductases P5.15 UNK, possibly glyoxylases P5.16 AhpC/TSA family P5.17 UNK, possibly exported proteins P5.18 Probable resusicitation-promoting factors, exported proteins P5.2 Molybdopterin biosynthesis, others ODD P5.20 Putative p60 homologues P5.21 Includes DNA ligases P5.22 UNK transcriptional regulator (GntR family) P5.23 Mycolyl transferases P5.24 Membrane proteins P5.25 Probable arylsulfatases P5.26 Nitrate reductase subunits P5.3 UNK P5.4 Probable acyltransferases P5.5 ODD 2/5=IS fragment P5.6 UNK P5.7 Probable secreted proteases P5.8 UNK P5.9 Various dioxygenases P6.1 Various ferredoxins, ferredoxin-dependent enzymes P6.10 Various sugar-phosphate nucleotide transferases, e.g. gluc-1-phosph thymidyltr. P6.11 UNK P6.12 UNK P6.13 Molybdopterin-converting proteins, MoaD/E P6.2 UNK P6.3 Resolvases, e.g. IS1539 family P6.4 Acetyl/propionyl CoA carboxylases P6.5 Probable cutinase precursors P6.6 UNK, P6.7 Acetolactate synthases, etc P6.8 Probable amidases P6.9 Various flavoproteins P7.1 Elongation and initiation factors, GTP-binding proteins P7.2 ODD P7.3 IS1560-like transposase P74.1 Probable ABC-transporters, MFS P8.1 UNK membrane protein with 2-3 ATP-binding sites P8.2 Probable amino acid transporters (12 TM) P8.3 Transposases e.g. IS1539 P8.4 Various aminotransferases P8.5 UNK (evolved by domain duplication) P8.6 Thioredoxins and dsb proteins P8.7 Various aminotransferases P8.8 Probable acyltransferases P9.1 Transposases e.g. IS1081 P9.2 UNK, conserved cysteines P9.3 Includes members of CBXX/CFQX family, 5 UNK P9.4 Various nucleotide sugar epimerases, dehydratases P9.5 UNK, possibly 2 domains
Partitions: Genes that share common ancestry with at least one other gene in M. tuberculosis have been partitioned according to the following definition: A set of genes defines a "partition" if, and only if, the following three properties are satisfied: a)each member of the set has at least one highly significant match with another member of the set; b)no member of the set has highly significant matches with members not included in the set; and c)the set cannot be partitioned into subsets verifying a) and b) (i.e. the set is minimal). Pn.p denotes partition number p including n distinct genes. For example: P24.1 denotes partition 1 including 24 distinct genes. "UNK" and "ODD" denote protein partitions for which the functions are either unknown or for which no single function is dominant, respectively. Back to top Visit the The Tuberculist Site.
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