Related articles:

• Müller AJ, Filipe-Santos O, Eberl G, Aebischer T, Späth GF, Bousso P. (2012). CD4 T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity, 37(1):147-157.

• Filipe-Santos O, Pescher P, Breart B, Lippuner C, Aebischer T, Glaichenhaus N, Späth GF, Bousso P (2009). A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection. Cell Host Microbe 6(1):23-33.

Intracellular pathogens have developed strategies to survive in infected cells and reduce their recognition by the innate and adaptive immune systems. Our lab wishes to define the mechanisms influencing the recognition of infected cells by effector lymphocytes in vivo. In addition, we aim to better understand the set of interactions that effector CD4 and CD8 T cells need to establish to resolve infection in peripheral tissue.
infections movie 1
CD4 T cells patrolling the dermis at the site of Leishmania major infections.
Intravital imaging was performed in the ear skin of mice infected with L. major parasites (red). Macrophages and neutrophils are green, parasite-specific T cells are brown and indicated by a circle. Click here to see the movie.
infections movies 2
Hotspot of antigen recognition at the site of Leishmania major infection.
Parasite specific T cells (green) stably interact with a limited number of L. major (red) infected cells. The area of contact is shown in white. Click here to see the movie.