Aspergillus fumigatus is the most ubiquitous
thermophyllic airborne fungus. Humans and animals constantly inhale its numerous
conidia (1-100 conidia / air mm3 indoors and outdoors). the soil
is the natural ecological niche of this saprophytic organism which plays an
essential role in the degradation and recycling of carbon and nitrogen (it is
indeed the unique fungal inhabitant of the compost).
The inhaled conidia
are normally eliminated in the immunocompetent host by innate immune mechanisms.
Aspergilloma and allergic bronchopulmonary aspergillosis, uncommon clinical
syndromes, are the only infections observed in such hosts.
was considered for years to be a weak pathogen. With increases in the number
of immunosuppressed patients, however, there has been a dramatic increase in
severe and usually fatal invasive aspergillosis, now the most common mold infection
The focus of the research in our laboratory is on the biology
of A. fumigatus and the diseases
it causes. Themes developed are centered both on clinical and fundamental aspects
using molecular, cellular and biochemical
methodologies. Three major research areas have been developed:
diagnosis of aspergillosis in immunocompetent and immunocompromised hosts,
identification of host and fungal factors that play a role in the establishment
of the fungus in vivo,
study of cell wall biosynthesis with the aim of discovering new antifungal drugs.
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75724 Paris Cedex 15
(33) 1 40 61 35 18
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