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| Unité
de Biologie |
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Head of the unit
Non exhaustive
list of publications
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72. Muschiol, S., Boncompain G., Vromman, F., Dehoux, P., Normak, S., Henriques-Normark, B., Subtil, A. (2011). "Identification of a family of effectors secreted by the type III secretion system that are conserved in pathogenic Chlamydiae." Infect Immun 79(2): 571-80. 71. Dehoux, P., R. Flores, Dauga, C., Zhong, G., Subtil, A. (2011). "Multi-genome identification and characterization of chlamydiae-specific type III secretion substrates: the Inc proteins." BMC Genomics, 12(1): 109. 70. Bourhy, H., Dautry-Varsat, A., Hotez, P.J., Salomon, J. (2010). Rabies, Still Neglected after 125 Years Of Vaccination. PLoS Negl Trop Dis, 4(11) :e839. 69. Meas-Yedid, V., Dufour, A., Zhang, B., Grassart, A., Sauvonnet N., Olivo-Marin J.-C. (2010). Automated quantification cellular processes with applications to high-content screening. Handbook of Pattern Recognition & Computer (4 Edn). Edited by Prof. C.H. Chen, to be published by World Scientific Publishing January 2010 p. 537-547. 68. Geny, B, Grassart, A, Manich, M Chicanne, G Payrastre, B Sauvonnet, N MR. Popoff. (2010). Rac1 inactivation by lethal toxin from Clostridium sordellii modifies Focal Adhesions upstream of actin depolymerization. Cell Microbiol, 12(2):217-32. 67. Pennini, M.E., Perrinet, S., Dautry-Varsat, A., Subtil, A. (2010). Histone Methylation by NUE, a Novel Nuclear Effector of the Intracellular Pathogen Chlamydia trachomatis. PLOS Pathog, 6(7): e1000995. 66. Grassart, A., Meas-Yedid, V., Dufour, A., Olivo-Marin, J-C., Dautry-Varsat, A., Sauvonnet, N. (2010). Pak1 Phosphorylation Enhances Cortactin –N-WASP Interaction in Clathrin-Caveolin-Independent Endocytosis. Traffic, 11(8) :1079-91. 65. Montes de Oca, P., Malardé, V., Proust, R., Dautry-Varsat, A., Gesbert, F. (2010). Ectodomain shedding of interleukin-2 receptor beta (IL-2Rβ) and generation of an intracellular functional fragment. JBC, in press. 64. Boncompain, G., Schneider, B., Delevoye, C., Kellermann, O., Dautry-Varsat, A., Subtil, A. (2010). Production of recative oxygen species is turned on and rapidly shut down in epithelial cells infected with Chlamydia trachomatis. Infect.Immun, 78(1) :80-7. 63. Antonescu, C.N., Foti, M., Sauvonnet, N., Klip, A.(2009) 62 Paumet, F., J. Wesolowski, A. Garcia-Diaz, C. Delevoye, N. Aulner, H. A. Shuman, A. Subtil, J. E. Rothman. (2009). Intracellular bacteria encode inhibitory SNARE-like proteins. PLoS One, 4 :e7375. 61. Malardé V, Proust R, Dautry-Varsat A, Gesbert F. (2009). NEDD4-2 associates with gamma(c) and regulates its degradation rate. Biochem Biophys Res Commun., 387(2) :409-413. 60. Muschiol, S., Normark, S., Henriques-Normark B., Subtil A. (2009). Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells. BioMed Cent., 9 :75. 59.Yamada, T., Dautry-Varsat, A. & Walport, M., (2008). Ready for avian flu ? Nature, 454 (7201) :162. 58. Delevoye C., Nilges M., Dehoux P., Paumet F., Perrinet S., Dautry-Varsat A., Subtil A. (2008). SNARE Protein Mimicry by an Intercellular Bacterium. PLoS Path., 4(3), e1000022. 57. Grassart, A., Dujeancourt A., , Lazarow P., Dautry-Varsat A., Sauvonnet N. (2008). Clathrin-independent endocytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2. EMBO Reports, 9(4), 356-362. 56. B., Wyplosz, G. Montalescot, A. Subtil, A. Dujeancourt, M.-L. Tanguy, R. Choussat, L. Capron, A. Dautry-Varsat. (2006). Correlation between Chlamydia pneumoniae detection from coronary angioplasty balloons and atherosclerosis severity. J.A.C.C., 47:1229-1231. 55. Subtil, A., Delevoye, C., Balañá, M.E., Tastevin, L., Perrinet, S., Dautry-Varsat, A. (2005). A directed screen for chlamydial proteins secreted by a type III mechanism identifies a translocated protein and numerous other new candidates. Mol Microbiol., 56, 1636-1647. 54. Balañá, M.E., Niedergang, F., Subtil, A., Alcover, A., Chavrier, P., Dautry-Varsat, A. (2005). ARF6 GTPase controls bacterial invasion by actin remodelling. J. Cell Sci., 118, 2201-2210. 53. Gesbert, F., Malarde, V., Dautry-Varsat, A. (2005). Ubiquitination of the common cytokine receptor gamma(c) and regulation of expression by an ubiquitination/deubiquitination machinery. Biochem Biophys Res Commun., 334, 474-480. 52. Sauvonnet, N., Dujeancourt, A., Dautry-Varsat, A. (2005). Cortactin and dynamin are required for the clathrin-independent endocytosis of gammac cytokine receptor. J. Cell Biol., 168, 155-163. 51. Gesbert, F., Sauvonnet, N., Dautry-Varsat, A. (2004). Clathrin-lndependent endocytosis and signalling of interleukin 2 receptors IL-2R endocytosis and signalling. Curr Top Microbiol Immunol., 286: 119-148. 50. Delevoye, C., M. Nilges, A. Dautry-Varsat, A. Subtil. (2004). Conservation of the biochemical properties of IncA from Chlamydia trachomatis and C. caviae: oligomerization of IncA mediates interaction between facing membranes. J. Biol. Chem., 279, 46896-46906(2004) 49. A. Subtil, B. Wyplosz, M.E. Balana, A. Dautry-Varsat. (2004). Analysis of Chlamydia caviae entry sites and involvement of Cdc42 and Rac activity. J. Cell Sci., 117, 3923-3933. 48. Dautry-Varsat, A., Balana, M. E., Wyplosz, B. (2004). Chlamydia -host cells interactions. Recent advances on bacterial entry and intracellular development. Traffic, 5, 561-570. 47. Subtil, A., Dautry-Varsat A. (2004). Chlamydia: Five years A. G. (After Genome). Curr. Op. Microbiol., 7, 84-92 46. Das, V., Nal, B., Dujeancourt, A., Thoulouze, M. I., Galli, T., Roux, P., Dautry-Varsat, A., Alcover, A. (2004). Activation-induced polarized recycling targets T cell receptors to the immunological synapse. Involvement of SNARE complexes. Immunity, 20, 577-588. 45. Jutras, I., Abrami, L., Dautry-Varsat, A. (2003). Chlamydia entry into host cells involves cholesterol-rich membrane domains. Infect. Immun.,71, 260-266. 44. Das, V., Nal, B., Roumier, A., Meas-Yedid, V., Zimmer, C., Olivo-Marin, J. C., Roux, P., Ferrier, P., Dautry-Varsat, A., Alcover, A. (2002). Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T cell activation. Immunol. Reviews, 189, 123-135. 43. Jutras, I., Subtil, A., Wyplosz, B., Dautry-Varsat, A. (2002). Chlamydia in "Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis", pp.179-189. Ed. J.P. Gorvel. R.G. Landes Publishing Co., Texas, USA. 42. Roumier, A., Olivo-Marin, J.C., Arpin, M., Michel, F., Martin, M., Mangeat, P., Acuto, O., Dautry-Varsat, A., Alcover, A. (2001). The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. Immunity, 15, 715-728. 41. Perfettini, J. L., Reed, J. C., Israël, N., Martinou, J. C., Dautry-Varsat, A., Ojcius, D. M. (2001). Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection : effect of apoptosis on the infection cycle. Infect. Immun. 70, 55-61. 40. Lamaze, C., Dujeancourt, A., Baba, T., Lo, C., Benmerah, A., Dautry-Varsat, A. (2001). Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway. Mol. Cell., 7, 661-671. 39. Rocca, A., Lamaze, C., Subtil, A., Dautry-Varsat, A. (2001). Involvement of the ubiquitin/proteasome system in sorting of the IL2 receptor beta chain to late endocytic compartments. Mol. Biol. Cell., 12, 1293-1301. 38. Subtil, A., Parsot, C., Dautry-Varsat, A. (2001). Secretion of predicted Inc proteins of Chlamydia pneumoniae by a heterologous type III machinery. Mol. Microbiol., 39, 792-800. 37. Dautry-Varsat, A. (2001). Clathrin-independent endocytosis, in "Endocytosis", pp. 26-57. Ed. M. Marsh. Oxford University Press. 36. Boleti, H., Ojcius, D.M., Dautry-Varsat, A. (2000). Fluorescent labelling of intracellular bacteria in living host cells. J. Microbiol. Meth., 40, 265-274. 35. Benmerah, A., Poupon, V., Cerf- Bensussan, N., Dautry-Varsat, A. (2000). Mapping of Eps15 domains involved in its targeting to clathrin-coated pits. J. Biol. Chem., 275, 3288-3295. 34. Perfettini, J. L., Darville, T., Gachelin, G., Souque, P., Huerre, M., Dautry-Varsat, A., Ojcius, D. M. (2000). Effect of Chlamydia trachomatis infection and subsequent TNF alpha secretion on apoptosis in the murine genital tract. Infect. Immun., 68, 2237-2244. 33. Subtil, A., Blocker, A., Dautry-Varsat, A. (2000). Type III secretion system in Chlamydia: identified members and candidates. Microbes Infect., 2, 367-369. 32. Chiu, Y. H, Jayawardena, J., Weiss, A., Lee, D., Park, S-H., Dautry-Varsat, A., Bendelac, A. (1999). Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. J. Exp. Med., 189, 103-110. 31. Boleti, H., Benmerah, A., Ojcius, D. M., Cerf-Bensussan, N., Dautry-Varsat, A. (1999). Chlamydia infection of epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth. J. Cell Sci., 112, 1487-1496. 30. Farge, E., Ojcius, D.M., Subtil, A., Dautry-Varsat, A. (1999). Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells. Am. J. Physiol. Cell Physiol., 276, 725-733. 29. Benmerah, A., Bayrou, M., Cerf-Bensussan, N., Dautry-Varsat, A. (1999). Inhibition of clathrin-coated pit assembly by an Eps15mutant. J. Cell Sci., 112, 1303-1311. 28. Ojcius, D., Souque, Ph., Perfettini, J. L., Dautry-Varsat, A. (1998). Apoptosis of epithelial cells and macrophages due to infection with the obligate intracellular pathogen Chlamydia psitacci. J. Immunol., 161, 4220-4226. 27. Subtil, A., Rocca, A., Dautry-Varsat, A. (1998). Molecular characterization of the signal responsible for the targeting of the IL2 receptor beta chaintowardintracellulardegradation. J. Biol. Chem., 273, 29424-29429. 26. Niedergang, F., Dautry-Varsat, A., Alcover, A. (1998). Cooperative activation of T cell receptors by enterotoxin superantigens. J. Immunol., 161, 6054-6058. 25. Ojcius, D., M., Degani, H., Mispelter, J., Dautry-Varsat, A. (1998). Enhancement of ATP levels and glucose metabolism during an infection by Chlamydia. NMR studies of living cells. J. Biol. Chem., 273, 7052-7058. 24. Subtil, A., Dautry-Varsat, A. (1998). Several weak signals in the cytosolic and transmembrane domains of the interleukin 2 receptor beta chain allow for its efficient endocytosis. Eur. J. Biochem., 253, 525-530. 23. Morelon, E., Dautry-Varsat, A. (1998). Endocytosis of the common cytokine receptor gamma chain: identification of sequences involved in internalization and degradation. J. Biol. Chem., 273, 22044-22051. 22. Benmerah, A., Lamaze, Ch., Bègue, B., Schmid, S.L., Dautry-Varsat, A., Cerf-Bensussan, N. (1998). AP-2/Eps15 interaction is required for receptor mediated endocytosis. J. Cell Biol., 140, 1055-1062. 21. Ojcius, D. M., Bravo, Y., Kanellopoulos, J.M., Hawkins, R.A., Kelly, K.A., Rank, R.G., Dautry-Varsat, A. (1998). Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells. J. Immunol., 160, 1297-1303. 20. Niedergang, F., San José, E., Rubin, B., Alarcón, B., Dautry-Varsat, A., Alcover, A. (1997). Differential cytosolic tail dependence and intracellular fate of T cell receptors internalized upon activation with superantigen or phorbol ester. Res. Immunol., 148, 231-245. 19. Subtil, A., Dautry-Varsat, A. (1997). Microtubule depolymerization inhibits clathrin coated-pit internalization in non-adherent cell lines while interleukin 2 endocytosis is not affected. J. Cell Sci., 110, 2441-2447. 18. Ojcius, D.M., Hellio, R., Dautry-Varsat, A. (1997). Distribution of endosomal, lysosomal and MHC markers in a monocytic cell line infected with Chlamydia psittaci. Infect. Immun., 65, 2437-2442. 17. Gutiérrez-Martin, C., Ojcius, D., Hsia, R-C, Hellio, R., Bavoil, P., Dautry-Varsat, A. (1997). Heparin-mediated inhibition of Chlamydia psittaci adherence to HeLa cells. Microb. Pathog., 22, 47-57. 16. Subtil, A., Delepierre, M., Dautry-Varsat, A. (1997). An alpha-helical signal in the cytosolic domain of the interleukin 2 receptor beta chain mediates sorting towards degradation after endocytosis. J. Cell Biol., 136, 583-595. 15. Niedergang, F., Dautry-Varsat, A., Alcover, A. (1997). Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors. J. Immunol., 159, 1703-1710. 14. Benmerah, A., Bègue, B., Dautry-Varsat, A., Cerf-Bensussan, N. (1996). The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps15 protein. J. Biol. Chem., 271, 12111-12116. 13. Morelon, E., Dautry-Varsat, A., Le Deist, F., Fischer, A., de Saint Basile, G. (1996). T lymphocyte differentiation and proliferation in the absence of the cytoplasmic tail of the common cytokine receptor gamma chain in a SCIDX1 patient. Blood, 88, 1708-1717. 12. Ojcius, D.M., Gachelin, G., Dautry-Varsat, A. (1996). Presentation of antigens derived from microorganisms residing in host-cell vacuoles. Trends Microbiol., 4, 53-59. 11. Niedergang, F., Hémar, A., Hewitt, C.R.A., Owen, M.J., Dautry-Varsat, A., Alcover, A. (1995). The Staphylococcus aureus enterotoxin B superantigen induces specific T cell receptor downregulation by increasing its internalization. J. Biol. Chem., 270, 12839-12845. 10. Schwartz, O., Dautry-Varsat, A., Goud, B., Maréchal, V., Subtil, A., Heard J-M, Danos, O. (1995). HIV type 1 Nef induces accumulation of CD4 in early endosomes. J. Virol. , 69, 528-533. 9. Hémar, A., Subtil, A., Lieb, M., Morelon, E., Hellio, R., Dautry-Varsat, A. (1995). Endocytosis of interleukin 2 receptors in human T lymphocytes : distinct intracellular localization and fate of the receptor alpha beta and gamma chains. J. Cell Biol., 129. 55-64. 8. Benmerah, A., Gagnon, J., Bèque, B., Mégarbané, B., Dautry-Varsat, A., Cerf-Bensussan, N. (1995). The tyrosine kinase substrate EPS15 is constitutively associated with the plasma membrane adaptor AP-2. J. Cell Biol., 131, 1831-1838. 7. DiSanto, J. P., Rieux-Laucat, F., Dautry-Varsat, A., Fischer, A., de Saint Basile G. (1994). Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells. Proc. Natl. Acad. Sci. (USA). 91, 9466-9470. 6. DiSanto, J.P., Dautry-Varsat, A., Certain, S., Fischer, A., de Saint Basile, G. (1994). IL2R gamma chain mutations in X-linked severe combined immunodeficiency disease result in the loss of high-affinity IL2 receptor binding. Eur. J. Immunol. , 24, 475-479 5. Subtil, A., Hémar, A., Dautry-Varsat, A. (1994). Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited. J. Cell Sci., 107, 3461-3468. 4. Hémar, A., Lieb, M., Subtil, A., DiSanto, J.P., Dautry-Varsat, A. (1994). Endocytosis of the beta chain of interleukin 2 receptor requires neither interleukin 2 nor the gamma chain. Eur. J. Immunol. , 24, 1951-1955. 3. Duprez, V., Smoljanovic, M., Lieb, M., Dautry-Varsat, A. (1994). Trafficking of Interleukin 2 and transferrin in endosomal fractions of T lymphocytes. J. Cell Sci. , 107, 1289-1295. 2. Ferrer, M., Hémar, A., Duprez, V., Hellio, R., Dautry-Varsat, A. (1993). Both the alpha and beta chains of high-affinity interleukin 2 receptors are located in intracellular vesicles when their ligand is endocytosed. Eur. J. Cell Biol., 60, 276-282. 1. Duprez, V., Ferrer, M., Dautry-Varsat, A. (1992). High-affinity Interleukin 2 receptor alpha and beta chains are internalized and remain associated inside the cells after Interleukin 2 endocytosis. J. Biol. Chem., 267, 18639-18643. |
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