Génétique des Génomes Bactériens
Genetics of Bacterial Genomes
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Activité 2000-2004

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1967-1971 IBPC-1981 REG-1986 REG-1991 REG-1996 GGB-2001 GGB-2006
1972-1974 IBPC-1982 REG-1987 REG-1992 REG-1997 GGB-2002
1975-1978 BRC-1983 REG-1988 REG-1993 REG-1998 GGB-2003
IBPC-1979 BRC-1984 REG-1989 REG-1994 REG-1999 GGB-2004
IBPC-1980 BRC-1985 REG-1990 REG-1995 GGB-2000 GGB-2005  

Peer-reviewed publications are indicated in red

Publications in the domain of Philosophy, History of Sciences and Ethics

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Lectures and seminars

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2006

M Bailly-Bechet, A Danchin, M Iqbal, M Marsili, M Vergassola
Codon usage domains over bacterial chromosomes
PLoS Computational Biology (2006) 2: e37 
PubMed codon usage F1000

Addendum (October 18, 2006)
coli_correl ( 20 K)

An issue left unexplained in this paper is the striking quantitative difference between E. coli and B. subtilis. This is clearly visible in Fig. 6, where it is shown the probability that two genes at distance l belong to the same cluster of codon usage. Clusters are characterized by a similar codon bias and were identified using a novel information-based clustering method. While both curves decay on distances sizably longer than what could be accounted by operons, B. subtilis curve manifestly features much longer correlations. It is hard to develop a biologically well-founded explanation for such a striking difference between the two organisms.

More (64 K)....

subtilis_correl (28 K)

uk-flagThe codon usage bias in genomes has long been associated to specific biological processes, and in particular to the horizontal transfer of genes. A finer analysis of the neighborhoods of genes with similar codon biases has uncovered an important functional correlation between neighboring genes. However, until the present work, the exact influence of translation had not been demonstrated. We show that the diffusion of rare or moderately expressed transfer RNAs is reflected in genomes by the formation of islands of common codon usage bias significantly longer than operons (30 kilobases in E. coli and 150 kilobases in B. subtilis) and that the distribution of these islands is correlated with the functions they code for.

 

fr-flagLe biais d'usage des codons dans les génomes a depuis longtemps été associé à des processus biologiques spécifiques, et en particulier au transfert horizontal des gènes. Une analyse plus fine des voisinages d'usage des mêmes codons a montré une importante corrélation fonctionnelle. Mais, jusqu'au travail ici présenté, l'influence exacte de la traduction n'avait pas été mise en évidence. Nous montrons que la diffusion des ARN de transfert rares ou modérément représentés se reflète dans les génomes par la formation d'îlots nettement plus longs que les opérons (30 kilobases chez E. coli et 150 kilobases chez B. subtilis) et que la répartition de ces îlots est corrélée aux fonctions qu'ils codent.

C Carapito, D Muller, E Turlin, S Koechler, A Danchin, A Van Dorsselaer, E Leize-Wagner, PN Bertin, MC Lett
Identification of genes and proteins involved in the pleiotropic response to arsenic stress in Caenibacter arsenoxydans, a metalloresistant beta-proteobacterium with an unsequenced genome
Biochimie (2006) 8: 595-606
PubMed PDF

E Couturier, EPC Rocha
Replication-associated gene dosage effects shape the genomes of fast-growing bacteria but only for transcription and translation genes
Mol Microbiol. (2006) 59:1 506-1518

fr A Danchin
Chroniques 2006 dans La Recherche

Les deux bouts de la lorgnette 397: 97
Le goût de la fraude 399: 113
Du bon usage de la guerre biologique 402: 97

A Danchin
Beneficial biological warfare
EMBO Rep (2006) 7:767
PubMed    PDF

A Danchin
Le Syndrome Chinois (commentaire sur le livre de KT Greenfeld)
La Recherche (2006) 401:89

A Danchin
Genomics in the fight against mycobacterial diseases
In: Development of New Antituberculosis Drugs (Editor WW Yew), Nova Science Publishers, Hauppauge NY, USA, (2006) pp 17-28
  antitub

S Even, P Burguière, S Auger, O Soutourina, A Danchin, I Martin-Verstraete
Global control of cysteine metabolism by CymR in Bacillus subtilis
J Bacteriol (2006) 188: 2184-2197
PubMed J_Bact

G Fischer, EPC Rocha, F Brunet, M Vergassola, B Dujon
Highly variable rates of genome rearrangements between hemiascomycetous yeast lineages
PLoS Genet (2006) 2: e32

SL Iverson-Cabral, SG Astete, CR Cohen, EPC Rocha, PA Totten
Intrastrain heterogeneity of the mgpB gene in Mycoplasma genitalium is extensive in vitro and in vivo and suggests that variation is generated via recombination with repetitive chromosomal sequences
Infect Immun (2006) 74: 3715-3726

U Mechold, V Ogryzko, S Ngo, A Danchin
Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells
Nucleic Acids Res (2006) 34: 2364-2373
PubMed pAp biosapiens b7

R Papa, S Glagla, A Danchin, T Schweder, G Marino, A Duilio
Proteomic identification of a two-component regulatory system in Pseudoalteromonas haloplanktis TAC125
Extremophiles (2006) 10: 483-490
PubMed

G Pascal, C Médigue, A Danchin
Persistent biases in the amino acid composition of prokaryotic proteins
Bioessays (2006) 28: 726-738
PubMed PDF  biosapiens b7

Z Qin, J Zhang, B Xu, L Chen, Y Wu, X Yang, X Shen, S Molin, A Danchin, H Jiang, D Qu
Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat Staphylococcus epidermidis infections
BMC Microbiology (2006) 6: 96
PubMed BMC epg

EPC Rocha
Inference and analysis of the relative stability of bacterial chromosomes
Mol Biol Evol. (2006) 23: 513-522

EPC Rocha, JM Smith, LD Hurst, MT Holden, JE Cooper, NH Smith, EJ Feil
Comparisons of dN/dS are time dependent for closely related bacterial genomes
J Theor Biol. 2006 239: 226-235

EPC Rocha
The quest for the universals of protein evolution
Trends Genet (2006) Jun 27; [Epub ahead of print]

E Turlin, G Pascal, JC Rousselle, P Lenormand, S Ngo, A Danchin, S Derzelle
Proteome analysis of the phenotypic variation process in Photorhabdus luminescens
Proteomics (2006) 6: 2705-2725
PubMed

W Wei, ZW Cao, YL Zhu, XJ Wang, GH Ding, H Xu, PL Jia, D Qu, A Danchin, YX Li
Conserved genes in a path from commensalism to pathogenicity: comparative phylogenetic profiles of Staphylococcus epidermidis RP62A and ATCC12228
BMC Genomics (2006) 7: 112
 PubMed BMC epg

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2007

S Chalabaev, E Turlin, JF Charles, A Namane, S Pagès, A Givaudan, E Brito-Fravallo, A Danchin, Biville F
The HcaR regulatory protein of Photorhabdus luminescens affects the production of proteins involved in oxidative stress and toxemia
Proteomics (2007) 7: 4499-4510
PubMed

A Danchin
Archives or palimpsests? Bacterial genomes unveil a scenario for the origin of life
Biological Theory (2007) 2: 52-61
b7 probactys

A Danchin
An interplay between metabolic and physicochemical constraints: Lessons from the psychrophilic prokaryote genomes
In: Physiology and biochemistry of extremophiles (C Gerday & N Glansdorff, Editors), ASM Press, Washington (2007) pp 208-220
  extremophiles

A Danchin
From the origin of life to Synthetic Biology
BIOforum Europe (2007) 6: 30-31; Highlights Issue (2008) 12: 4-6

fr A Danchin
De la biologie symplectique à la biologie synthétique

In: L'Homme Artificiel (sous la direction de JP Changeux), Odile Jacob, Paris (2007) pp 61-86

fr A Danchin
Chroniques 2007 dans La Recherche

Masse et connaissance 404: 95
La recherche "motivée" 406: 97
Papillons cosmiques 408: 95

Le malade peut attendre 411: 97

it A Danchin
Sapremo costruire un batterio artificiale?
Prometeo (2007) 25 (100): 14-29

A Danchin, G Fang, S Noria
The extant core bacterial proteome is an archive of the origin of life
Proteomics (2007) 7: 875-889
PubMed biosapiens b7 epg

MF Hullo, S Auger, O Soutourina, O, Barzu, M Yvon, A Danchin, I Martin-Verstraete
The conversion of methionine to cysteine in Bacillus subtilis and its regulation
J Bacteriol (2007) 189: 187-197
PubMed J_Bact

Y Makita, MJL de Hoon, A Danchin
Hon-yaku: a biology-driven Bayesian methodology for identifying translation initiation sites in prokaryotes
BMC Bioinformatics (2007) 8: 47
PubMed BMC biosapiens

U Mechold, G Fang, S Ngo, V Ogryzko, A Danchin
YtqI from Bacillus subtilis has both oligoribonuclease and pAp-phosphatase activity
Nucleic Acids Res (2007) 35: 4552-4561
PubMed pAp biosapiens b7

D Muller, C Medigue, S Koechler,V Barbe, M Barakat, E Talla, V Bonnefoy, E Krin, F Arsene-Ploetze, C Carapito, M Chandler, B Cournoyer, S Cruveiller, C Dossat, S Duval, M Heymann, E Leize, A Lieutaud, D Lievremont, Y Makita, S Mangenot, W Nitschke, P Ortet, N Perdrial, B Schoepp, P Siguier, DD Simeonova, Z Rouy, B Segurens, E Turlin, D Vallenet, A Van Dorsselaer, S Weiss, J Weissenbach, MC Lett, A Danchin, PN Bertin
A tale of two oxidation states: bacterial colonization of arsenic-rich environments.
PLoS Genetics (2007) 3: e53
PubMed codon usage

TW Ng, G Turinici, WK Ching, SK Chung, A Danchin
A parasite vector-host epidemic model for TSE propagation
Medical Science Monitor (2007) 13: 59-66
PubMed
PDF

G Turinici, A Danchin
SARS: an alarm clock
In: Encyclopedia of infectious diseases. Modern methodologies (M Tibayrenc, Editor), Wiley, NY (2007) pp 151-162
  double_epidemic
HKU_Pasteur
RM Watt, J Wang, M Leong, HF Kung, KS Cheah, D Liu, A Danchin, JD Huang
Visualizing the proteome of Escherichia coli: an efficient and versatile method for labeling chromosomal coding DNA sequences (CDSs) with fluorescent protein genes
Nucleic Acids Res (2007) 35: e37 PubMed pAp F1000

Y Wu, K Yu, B Xu, L Chen, X Chen, J Mao, A Danchin, X Shen, D Qu, H Jiang
Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase
J Antimicrobial Chemotherapy (2007) 60: 502-509
PubMed

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2008

H Ashida, Y Saito, T Nakano, N Tandeau de Marsac, A Sekowska, A Danchin, A Yokota
RuBisCO-like proteins as the enolase enzyme in the methionine salvage pathway: functional and evolutionary relationships between RuBisCO-like proteins and photosynthetic RuBisCO
J Exp Bot (2008) 59: 1543-1554
PubMed

S Chalabaev, E Turlin, S Bay, C Ganneau, E Brito-Fravallo, J-F Charles, A Danchin, F Biville
Cinnamic acid, an autoinducer of its own biosynthesis, is processed via Hca enzymes in Photorhabdus luminescens
Appl Environ Microbiol (2008) 74:1717-1725
PubMed probactys

fr A Danchin
Chroniques 2008 dans La Recherche

Est-il permis de penser l'avenir ?, 415: 113
Voir et regarder, entendre et écouter 418: 97

fr A Danchin
Saurons-nous construire une bactérie synthétique ?
Médecine/Sciences 24: 533-540

G Fang, EP Rocha, A Danchin
Persistence drives gene clustering in bacterial genomes
BMC Genomics (2008) 9: 4
PubMed BMC biosapiens b7 HA

E Krin, S Derzelle, K Bedard, M Adib-Conquy, E Turlin, P Lenormand, M-F Hullo, I Bonne, N Chakroun, C Lacroix, A Danchin
Regulatory role of UvrY in adaptation of Photorhabdus luminescens growth inside the insect
Environmental Microbiology (2008) 10: 1118–1134
PubMed

A Ménard, A Danchin, S Dupouy, F Mégraud, P Lehours
A variable gene in a conserved region of the Helicobacter pylori genome: Isotopic gene replacement or rapid evolution?
DNA Res (2008) 15: 163-168
PubMed

M Riley, JT Staley, A Danchin, TZ Wang, TS Brettin, LJ Hauser, ML Land, LS Thompson
Genomics of an extreme psychrophile, Psychromonas ingrahamii
BMC Genomics 9: 210  PubMed 
BMC HA

Dernière mise à jour 7 juillet 2008
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Last update july 7th, 2008




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