> Pathogénie Microbienne Moléculaire - INSERM U786
  Head : Philippe Sansonetti

Unité de pathogénie
microbienne moléculaire

Institut Pasteur
28, rue du Docteur Roux
75724 Paris Cedex 15
Tel. 33 1 40 61 30 95
fax 33 1 45 68 89 53
e-mail : secrétariat
Researchers in the Unité de Pathogénie Microbienne Moléculaire, a component of Unité INSERM 786, are currently studying the invasion and inflammatory destruction of the intestinal barrier by the bacterial pathogen Shigella, the causative agent of Bacillary Dysentery, a disease that causes about one million deaths in young children of the most impoverished areas of the planet. A multidisciplinary approach is applied to this topic through the integration of various disciplines such as molecular genetics and genomics, cell biology, experimental medicine and immunology. More recently we have tackled to study the interactions established between the intestinal epithelium and its commensal flora.
Beyond deciphering the molecular cross talks between the pathogen and the intestinal epithelium that lead to its invasion, our work is also at the heart of understanding the physiology of the intestinal barrier, the rules of commensalism as well as the mechanisms that lead to inflammatory bowel diseases such as Crohn's Disease and Ulcerative Colitis. It is also aimed at developing a vaccine against Bacillary Dysentery.
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