Institut Pasteur

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- Research articles and reviews
- Bookchapters

Research articles, reviews and commentaries


2014


Boritsch, E.C., Supply, P., Honore, N., Seeman, T., Stinear, T.P., and Brosch, R. (2014) A glimpse into the past and predictions for the future: The molecular evolution of the tuberculosis agent. Mol Microbiol. 93:835-52 , PubMed PMID: 25039682 .

Bottai, D., Stinear, T.P., Supply, P., and Brosch, R. (2014) Mycobacterial Pathogenomics and Evolution. Microbiol Spectrum 2:MGM2-0025-2013.

Gonzalo-Asensio, J., Malaga, W., Pawlik, A., Astarie-Dequeker, C., Passemar, C., Moreau, F., Laval., F., Daffe, M., Martin, C., Brosch, R., and Guilhot C. (2014) Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator. Proc Natl Acad Sci U S A. 111:11491-6 .

Gouzy, A., Larrouy-Maumus, G., Bottai, D., Levillain, F., Dumas, A., Wallach, J.B., Caire-Brandli, I., de Chastellier, C., Wu, T.D., Poincloux, R., Brosch, R., Guerquin-Kern, J.L., Schnappinger, D., Sorio de Carvalho, L.P., Poquet, Y., and Neyrolles, O. (2014) Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection. PLoS Pathog. 10:e1003928

Le Chevalier, F., Cascioferro, A., Majlessi, L., Herrmann, J.L., and Brosch, R. (2014) Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development. Future Microbiol.9:969-85 .

Rentsch, C.A., Birkhäuser, F.D., Biot, C., Gsponer, J.R., Bisiaux, A., Wetterauer, C., Lagranderie, M., Marchal, G., Orgeur, M., Bouchier, C., Bachmann, A., Ingersoll, M., Brosch, R., Albert, M.L., and Thalmann, G.N. (2014) Bacillus Calmette-Guérin Strain Differences Have an Impact on Clinical Outcome in Bladder Cancer Immunotherapy . Eur Urol. 66:677-88 .

Solans, L., Aguilo, N., Samper, S., Pawlik, A., Frigui, W., Martin, C., Brosch, R., and Gonzalo-Asensio J. (2014) A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component. Infect Immun. 82:3446-56. .

2013


Aguilo, J., Alonso, H., Uranga, S., Marinova, D., Arbues, A., Martino, A., Anel, A., Monzon, M., Badiola, J., Pardo, J., Brosch, R., and Martin, C. (2013) ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis. Cell Microbiol. 15:1994-2005.

Bottai, D., Serafini, A., Cascioferro, A., Brosch, R., and Manganelli, R. (2013) Targeting Type VII/ESX Secretion Systems for Development of Novel Antimycobacterial Drugs.Curr Pharm Des. [Epub ahead of print]

Brennan, P.J., Brosch, R., Birren, B., and Sobral, B. (2013) TBCAP; tuberculosis annotation project. Tuberculosis (Edinb) 93:1-5. .

Keller, C., Mellouk, N., Danckaert, A., Simeone, R., Brosch, R., Enninga, J., and Bobard, A. (2013) Single cell measurements of vacuolar rupture caused by intracellular pathogens. J Vis Exp. 12;(76).

Pawlik, A., Garnier, G., Orgeur, M., Tong, P., Lohan, A., Le Chevalier, F., Sapriel, G., Roux, A.L., Conlon, K., Honore, N., Dillies, M.A., Ma, L., Bouchier, C., Coppee, J.Y., Gaillard, J.L., Gordon, S.V., Loftus, B., Brosch, R., and Herrmann, J.L. (2013) Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus. Mol Microbiol. 90:612-629.

Supply, P., Marceau, M., Mangenot, S., Roche, D., Rouanet, C., Khanna, V., Majlessi, L., Criscuolo, A., Tap, J., Pawlik, A., Fiette, L., Orgeur, M., Fabre, M., Parmentier, C., Frigui, W., Simeone, R., Boritsch, E.C., Debrie, A.S., Willery, E., Walker, D., Quail, M.A., Ma, L., Bouchier, C., Salvignol, G., Sayes, F, Cascioferro, A., Seemann, T., Barbe, V., Locht, C., Gutierrez, M.C., Leclerc, C., Bentley, S.D., Stinear, T.P., Brisse, S., Medigue, C., Parkhill, J., Cruveiller, S., and Brosch, R. (2013) Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Nat Genet. 45:172-9 .

van Ingen, J., Brosch, R., and van Soolingen, D. (2013) Characterization of Mycobacterium orygis. Emerg Infect Dis. 19:521-2.

2012


Banu, S., Mahmud, A.M., Rahman, M.T., Hossain, A., Uddin, M.K., Ahmed, T., Khatun, R., Akhanda, W., and Brosch, R. (2012) Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh. PLoS One 7:e40545

Banu, S., Uddin, M. K. M., Islam, M. R., Zaman, K., Ahmed, T., Talukder, A.H., Rahman, M. T., Rahim, Z., Akter, N., Khatun, R., Brosch, R., and Endtz, H.P. (2012) Molecular epidemiology of tuberculosis in rural Matlab, Bangladesh. Int J Tuberc Lung Dis 16:319-326

Bottai, D., Di Luca, M., Majlessi, L., Frigui, W., Simeone, R., Sayes, F., Bitter, W., Brennan, M.J., Leclerc, C., Batoni, G., Campa, M., Brosch, R., and Esin, S. (2012) Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. Mol Microbiol. 83:1195-209.

Di Luca, M., Bottai, D., Batoni, G., Orgeur, M., Aulicino, A., Counoupas, C., Campa, M., Brosch, R., and Esin, S. (2012) The ESX-5 Associated eccB-eccC Locus Is Essential for Mycobacterium tuberculosis Viability. PLoS One. 7:e52059.

Dorhoi, A., Nouailles, G., Jorg, S., Hagens, K., Heinemann, E., Pradl, L., Oberbeck-Muller, D., Duque, M.A., Reece, S.T., Ruland, J., Brosch, R., Tschopp, J., Gross, O., and Kaufmann, S.H. (2012) Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is un coupled from susceptibility to active tuberculosis. Eur J Immunol. 42:374-384.

Houben, D., Demangel, C., van Ingen, J., Perez, J., Baldeon, L., Abdallah, A.M., Caleechurn, L., Bottai, D., van Zon, M., de Punder, K., van der Laan, T., Kant, A., Bossers-de Vries, R., Willemsen, P., Bitter, W., van Soolingen, D., Brosch, R., van der Wel, N., and Peters, P.J. (2012) ESX-1 Mediated Translocation to the Cytosol controls Virulence of Mycobacteria. Cell Microbiol. 14:1287-1298.

Romagnoli, A., Etna, M.P., Giacomini, E., Pardini, M., Remoli, M.E., Corazzari, M., Falasca, L., Goletti, D., Gafa, V., Simeone, R., Delogu, G., Piacentini, M., Brosch, R., Fimia, G.M., and Coccia, E.M. (2012) ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells. Autophagy. 8:1357-1370 .

Sayes, F., Sun, L., Di Luca, M., Simeone, R., Degaiffier, N., Fiette, L., Esin, S., Brosch, R., Bottai, D., Leclerc, C., and Majlessi, L. (2012) Strong Immunogenicity and Cross-Reactivity of Mycobacterium tuberculosis ESX-5 Type VII Secretion -Encoded PE-PPE Proteins Predicts Vaccine Potential. Cell Host Microbe. 11:352-63.

Simeone, R., Bobard, A., Lippmann, J., Bitter, W., Majlessi, L., Brosch, R., and Enninga, J. (2012) Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death. PLoS Pathog. 8:e1002507.

van Ingen, J., Rahim, Z., Mulder, A., Boeree, M.J., Simeone, R., Brosch, R., and van Soolingen, D. (2012) Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies. Emerg Infect Dis. 18:653-5 .


2011


Alonso, H., Aguilo, J.I., Samper, S., Caminero, J.A., Campos-Herrero, M.I., Gicquel, B., Brosch, R., Martin, C., and Otal, I. (2011) Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237. Tuberculosis 91(2):117-26 .

Bottai, D., Majlessi, L., Simeone, R., Frigui, W., Laurent, C., Lenormand, P., Chen, JM., Rosenkrands, I., Huerre, M., Leclerc, C., Cole, S.T., and Brosch, R. (2011). ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis. J Infect Dis. 203:1155-64.

Guenin-Mace, L., Carrette, F., Asperti-Boursin, F., Le Bon, A., Caleechurn, L., Di Bartolo, V., Fontanet, A., Bismuth, G., and Demangel, C. (2011) Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression. Proc Natl Acad Sci U S A. 108:12833-8.

Mostowy, S., Sancho-Shimizu, V., Hamon, M.A., Simeone, R., Brosch, R., Johansen, T., and Cossart, P. (2011) p62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathways. J Biol Chem. 286:26987-95.

Roux, A. L. Ray, A, Pawlik, A., Medjahed H., Etienne, G., Rottman, M., Catherinot, E., Coppee J.Y., Chaoui, K., Monsarrat, B., Toubert, A., Daffe, M., Puzo, G., Gaillard , J.L., Brosch, R., Dulphy, N., Nigou, J., and Herrmann, J.L. (2011) Over-expression of proinflammatory TLR-2- signaling lipoproteins in hypervirulent mycobacterial variants. Cell Microbiol. 13:692-704.

Sarfo, F.S., Le Chevalier, F., Aka, N., Phillips, R.O., Amoako, Y., Boneca, I.G., Lenormand, P., Dosso, M., Wansbrough-Jones, M., Veyron-Churlet, R., Guenin-Mace, L, and Demangel, C. (2011) Mycolactone diffuses into the peripheral blood of buruli ulcer patients - implications for diagnosis and disease monitoring. PLoS Negl Trop Dis. 5:e1237.

2010


Brodin, P., Poquet, Y., Levillain, F., Peguillet, I., Larrouy-Maumus, G., Gilleron, M., Ewann, F., Christophe, T., Fenistein, D., Jang, J., Jang, M.S., Park, S.J., Rauzier, J., Carralot, J.P., Shrimpton, R., Genovesio, A., Gonzalo Asensio, J.A., Puzo, G., Martin, C., Brosch, R., Stewart G.R., Gicquel, B., and Neyrolles, O. (2010). High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling. PLoS Pathog. 6: e1001100.

Boulkroun, S., Guenin-Mace, L., Thoulouze, M.I., Monot, M., Merckx, A., Langsley G., Bismuth, G., Di Bartolo, V., and Demangel C. (2010) Mycolactone Suppr esses T Cell Responsiveness by Altering Both Early Signaling and Posttranslation al Events. J Immunol 184:1436-44.

Fears, R., Kaufmann, S., Ter Meulen, V., Zumla, A., and on behalf of the EASAC Working Group. (2010) Drug-resistant tuberculosis in the European Union: opportunities and challenges for control. Tuberculosis (Edinb). 90:182-7.

Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, and Cossart P. (2010) Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures. Cell Host Microbe. 8:433-44.

Tabouret G, Astarie-Dequeker C, Demangel C, Malaga W, Constant P, Ray A, Honori N, Bello NF, Perez E, Daffi M, and Guilhot C. (2010) Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes. PLoS Pathog. 6:e1001159.

Termentzi, A., Khouri, I., Gaslonde, T., Prado, S., Saint-Joanis, B., Bardou, F., Amanatiadou, E.P., Vizirianakis, I.S., Kordulakova, J., Jackson, M., Brosch, R., Janin, Y.L., Daffi, M., Tillequin, F., and Michel, S. (2010) Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring. Eur J Med Chem. 45:5833-47.

2009


Alvey, L., Prado, S., Saint-Joanis, B., Michel, S., Koch, M., Cole, S.T., Tillequin, F., and Janin, Y.L. (2009) Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity. Eur J Med Chem. 44:2497-505.

Bitter, W., Houben, E.N., Bottai, D., Brodin, P., Brown, E.J., Cox, J.S., Derbyshire, K., Fortune, S.M., Gao, L.Y., Liu, J., Gey van Pittius, N.C., Pym, A.S., Rubin, E.J., Sherman, D.R., Cole, S.T., and Brosch, R. (2009) Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog. 5:e1000507.

Bottai, D., and Brosch, R. (2009) Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families. Mol Microbiol.73:325-8

Christophe, T., Jackson, M., Jeon, H.K., Fenistein, D., Contreras-Dominguez, M., Kim, J., Genovesio, A., Carralot, J.P., Ewann, F., Kim, E.H., Lee, S.Y., Kang, S., Seo, M.J., Park, E.J., Skovierova, H., Pham, H., Riccardi, G., Nam, J.Y., Marsollier, L., Kempf, M., Joly-Guillou, M.L., Oh, T., Shin, W.K., No, Z., Nehrbass, U., Brosch, R., Cole, S.T., and Brodin, P. (2009) High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog. 5:e1000645.

Demangel, C., Stinear, T.P., and Cole, S.T. (2009) Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans. Nat Rev Microbiol. 7:50-60.

Geluk, A., Spencer, J.S., Bobosha, K., Pessolani, M.C., Pereira, G.M., Banu, S., Honore, N., Reece, S.T., MacDonald, M., Sapkota, B.R., Ranjit, C., Franken, K.L., Zewdie, M., Aseffa, A., Hussain, R., Stefani, M.M., Cho, S.N., Oskam, L., Brennan, P.J., Dockrell, H.M.; IDEAL Consortium. (2009) From genome-based in silico predictions to ex vivo verification of leprosy diagnosis. Clin Vaccine Immunol. 16:352-9

Gordon, S.V., Bottai, D., Simeone, R., Stinear, T.P., and Brosch, R. (2009) Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants. Bioessays 31:378-88.

Guenin-Mace, L., Simeone, R., and Demangel, C. (2009) Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression. Transbound Emerg Dis. 56:255-68

Huygen, K., Adjei, O., Affolabi, D., Bretzel, G., Demangel, C., Fleischer, B., Johnson, R.C., Pedrosa, J., Phanzu, D.M., Phillips, R.O., Pluschke, G., Siegmund, V., Singh, M., van der Werf, T.S., Wansbrough-Jones, M., and Portaels, F. (2009) Buruli ulcer disease: prospects for a vaccine. Med Microbiol Immunol. 198:69-77

Makarov, V., Manina, G., Mikusova, K., Möllmann, U., Ryabova, O., Saint-Joanis, B., Dhar, N., Pasca, M.R., Buroni, S., Lucarelli, A.P., Milano, A., De Rossi, E., Belanova, M., Bobovska, A., Dianiskova, P., Kordulakova, J., Sala, C., Fullam, E., Schneider, P., McKinney, J.D., Brodin, P., Christophe, T., Waddell, S., Butcher, P., Albrethsen, J., Rosenkrands, I., Brosch, R., Nandi, V., Bharath, S., Gaonkar, S., Shandil, R.K., Balasubramanian, V., Balganesh, T., Tyagi, S., Grosset, J., Riccardi, G., and Cole, S.T. (2009). Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis. Science 324:801-804.

Monot, M., Honore, N., Garnier, T., Zidane, N., Sherafi, D., Paniz-Mondolfi, A., Matsuoka, M., Taylor, G.M., Donoghue, H.D., Bouwman, A., Mays, S., Watson, C., Lockwood, D., Khamispour, A., Dowlati, Y., Jianping, S., Rea, T.H., Vera-Cabrera, L., Stefani, M.M., Banu, S., Macdonald, M., Sapkota, B.R., Spencer, J.S., Thomas, J., Harshman, K., Singh, P., Busso, P., Gattiker, A., Rougemont, J., Brennan, P.J., and Cole, S.T. (2009) Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat Genet. 42:361.

Phillips, R., Sarfo, F.S., Guenin-Mace, L., Decalf, J., Wansbrough-Jones, M., Al bert, M.L., and Demangel, C. (2009) Immunosuppressive signature of cutaneou s Mycobacterium ulcerans infection in the peripheral blood of patients wi th buruli ulcer disease. J Infect Dis. 200: 1675-84. .

Ripoll, F., Pasek, S., Schenowitz, C., Dossat, C., Barbe, V., Rottman, M., Macheras, E., Heym, B., Herrmann, J.L., Daffe, M., Brosch, R., Risler, J.L., and Gaillard, J.L. (2009) Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus. PLoS One. 4:e5660.

Saint-Joanis, B, and Brosch, R. (2009) Decouverte d'une nouvelle classe tres prometteuse d'antituberculeux: les benzothiazinones (BTZ). [A promising new class of antituberculous molecules]. Med Sci (Paris) 25: 663-665.

Simeone, R., Bottai, D., and Brosch, R. (2009) ESX/type VII secretion systems and their role in host-pathogen interaction. Curr Opin Microbiol. 12:4-10.

Smith, N.H., Hewinson, R.G., Kremer, K., Brosch, R., and Gordon, S.V. (2009) Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis. Nat Rev Microbiol. 7:537-44.

2008


Alvey, L., Prado, S., Huteau, V., Saint-Joanis, B., Michel, S., Koch, M., Cole, S.T., Tillequin, F., and Janin, Y.L. (2008) A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial. Bioorg Med Chem. 16:8264-72.

Frigui, W., Bottai, D., Majlessi, L., Monot, M., Josselin, E., Brodin, P., Garnier, T., Gicquel, B., Martin, C., Leclerc, C., Cole, S. T., and Brosch, R. (2008). Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP PLoS Pathog. 4(2): e33 . (pdf).

Hong, H., Coutanceau, E., Leclerc, M., Caleechurn, L., Leadlay, P.F., and Demangel, C. (2008) Mycolactone Diffuses from Mycobacterium ulcerans-Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs. PLoS Negl Trop Dis.2:e325.

Hong, H., Demangel, C., Pidot, S.J., Leadlay, P.F., and Stinear, T. (2008) Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat Prod Rep. 25:447-454.

Monot, M., Honore, N., Baliere, C., Ji, B., Sow, S., Brennan, P.J., and Cole, S.T. (2008) Are Variable Number Tandem Repeats (VNTR) Appropriate for Genotyping Mycobacterium leprae ?. J Clin Microbiol.

Skekely, R., Waczek, F., Szabadkai, I., Nemeth, G., Hegymegi-Barakonyi, B., Eros, D., Szokol, B., Pato, J., Hafenbradl, D., Satchell, J., Saint-Joanis, B., Cole, S.T., Orfi, L., Klebl, B.M., and Keri, G. (2008). A novel drug discovery concept for tuberculosis: Inhibition of bacterial and host cell signalling. Immunol Lett. 116:225-31.

Stinear, T.P., Seemann, T., Harrison, P.F., Jenkin, G.A., Davies, J.K., Johnson, P.D., Abdellah, Z., Arrowsmith, C., Chillingworth, T., Churcher, C., Clarke, K., Cronin, A., Davis, P., Goodhead, I., Holroyd, N., Jagels, K., Lord, A., Moule, S., Mungall, K., Norbertczak, H., Quail, M.A., Rabbinowitsch, E., Walker, D., White, B., Whitehead, S., Small, P.L., Brosch, R., Ramakrishnan, L., Fischbach, M.A., Parkhill, J., and Cole, S.T. (2008) Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res. 18:729-41

Wheeler, P.R., Brosch, R., Coldham, N.G., Inwald, J.K., Hewinson, R.G., and Gordon S.V. (2008) Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism. Microbiology, 154: 3731-3742

2007


Brosch, R., Gordon, S.V., Garnier, T., Eiglmeier, K., Frigui, W., Valenti, P., Dos Santos, S., Duthoy, S., Lacroix, C., Garcia-Pelayo, C., Inwald, J.K., Golby, P., Nunez Garcia, J., Hewinson, R.G., Behr, M.A., Quail, M.A., Churcher, C., Barrell, B.G., Parkhill, J., and Cole, S.T. (2007) Genome plasticity of BCG and impact on vaccine efficacy. Proc Natl Acad Sci U S A. 104: 5596-5601, (news1, news2, news3, news4).

Brosch, R., and Vincent, V. (2007) Cutting-edge science and the future of tuberculosis control. Bull World Health Organ. 85:410-412, (pdf).

Coutanceau, E., Decalf, J., Martino, A., Babon, A., Winter, N., Cole, S.T., Albert, M.L., and Demangel, C.(2007) Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone. J Exp Med. 204:1395-403 , (JEM highlight-commentary).

de Jonge, M.I., Pehau-Arnaudet, G., Fretz, M.M., Romain, F., Bottai, D., Brodin, P., Honore, N., Marchal, G., Jiskoot, W., England, P., Cole, S.T., and Brosch, R. (2007) ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. J Bacteriol. 189:6028-34

Hong, H., Stinear, T., Porter, J., Demangel, C., and Leadlay, P.F. (2007) A novel mycolactone toxin obtained by biosynthetic engineering. Chembiochem. 8: 2043-2047.

Marsollier, L., Brodin, P., Jackson, M., Kordulakova, J., Tafelmeyer, P., Carbonnelle, E., Aubry, J., Milon, G., Legras, P., Andre, J.P., Leroy, C., Cottin, J., Guillou, M.L., Reysset, G., and Cole, S.T. (2007) Impact of Mycobacterium ulcerans Biofilm on Transmissibility to Ecological Niches and Buruli Ulcer Pathogenesis. PLoS Pathog. 3:e62.

Marsollier, L., Deniaux, E., Brodin, P., Marot, A., Wondje, C.M., Saint-Andre, J.P., Chauty, A., Johnson, C., Tekaia, F., Yeramian, E., Legras, P., Carbonnelle, B., Reysset, G., Eyangoh, S., Milon, G., Cole, S.T., and Aubry, J. (2007) Protection against Mycobacterium ulcerans Lesion Development by Exposure to Aquatic Insect Saliva. PLoS Med. 4:e64 .

Prado, S., Janin, Y. L., Saint-Joanis, B., Brodin, P., Michel, S., Koch, M., Cole, S. T., Tillequin, F., and Bost, P. E. (2007) Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues.Bioorg Med Chem. 15:2177-86 .

Stinear, T. P., Seemann, T., Pidot, S., Frigui, W., Reysset, G., Garnier, T., Me urice, G., Simon, D., Bouchier, C., Ma, L., Tichit, M., Porter, J. L., Ryan, J., Johnson, P. D., Davies, J. K., Jenkin, G. A., Small, P. L., Jones, L. M., Tekai a, F., Laval, F., Daffe, M., Parkhill, J., and Cole, S. T. (2007) Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulce rans, the causative agent of Buruli ulcer. Genome Res. 7:192-200.

2006



Araoz, R., Honore, N., Banu, S., Demangel, C., Cissoko, Y., Arama, C., Mafij Uddin, M.K., Abdul Hadi, S.K., Monot, M., Cho, S.N., Ji, B., Brennan, P.J., Sow, S., and Cole, S.T.(2006) Towards an immunodiagnostic test for leprosy. Microbes Infect. 8:2270-2276 .

Araoz, R., Honore, N., Cho, S., Kim, J.P., Cho, S.N., Monot, M., Demangel, C., Brennan, P.J., and Cole S.T. (2006) Antigen discovery: a postgenomic approach to leprosy diagnosis. Infect Immun. 74:175-82.

Brisse, S., Supply, P., Brosch, R., Vincent, V., and Gutierrez, M.C. (2006) A Re-Evaluation of M. prototuberculosis: Continuing the Debate. PLoS Pathog 2(9): e95.

Brodin, P., Majlessi, L., Marsollier, L., de Jonge, M.I., Bottai, D., Demangel, C., Hinds, J., Neyrolles, O., Butcher, P.D., Leclerc, C., Cole, S.T., and Brosch, R. (2006) Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect Immun. 74:88-98.

Coutanceau, E., Legras, P., Marsollier, L., Reysset, G., Cole, S.T., and Demangel C. (2006) Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer. Microbes Infect. 8:2075-81.

Fernandez, P., Saint-Joanis, B., Barilone, N., Jackson, M., Gicquel, B., Cole, S.T., and Alzari, P.M.(2006) The Ser/Thr protein kinase PknB is essential to sustain mycobacterial growth. J Bacteriol. 188:7778-84.

Hervas-Stubbs, S., Majlessi, L., Simsova, M., Morova, J., Rojas, M.J., Nouze, C., Brodin, P., Sebo, P., and Leclerc, C. (2006) High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection. Infect Immun. 74:3396-407.

Majlessi, L., Simsova, M., Jarvis, Z., Brodin, P., Rojas, M.J., Bauche, C., Nouze, C., Ladant, D., Cole, S.T., Sebo, P., Leclerc, C. (2006) An Increase in Antimycobacterial Th1-Cell Responses by Prime-Boost Protocols of Immunization Does Not Enhance Protection against Tuberculosis. Infect Immun. 74:2128-37.
.

Rosas-Magallanes, V., Deschavanne, P., Quintana-Murci, L., Brosch, R., Gicquel, B., Neyrolles, O. (2006) Horizontal Transfer of a Virulence Operon to the Ancestor of Mycobacterium tuberculosis. Mol Biol Evol. 23:1129-35

Prado, S., Ledeit, H., Michel, S., Koch, M., Darbord, J.C., Cole, S.T., Tillequin, F., and Brodin, P. (2006) Benzofuro[3,2-f][1]benzopyrans: A new class of antitubercular agents. Bioorg Med Chem 14:5423-8.

Saint-Joanis, B., Demangel, C., Jackson, M., Brodin, P., Marsollier, L., Boshoff, H., and Cole, S.T. (2006). Inactivation of Rv2525c, a Substrate of the Twin Arginine Translocation (Tat) System of Mycobacterium tuberculosis, Increases {beta}-Lactam Susceptibility and Virulence. J Bacteriol. 188:6669-79.



2005



Brodin, P., de Jonge, M.I., Majlessi, L., Leclerc, C., Nilges, M., Cole, S.T., and Brosch R. (2005) Functional analysis of ESAT-6, the dominant T-cell antigen of Mycobacterium tuberculosis , reveals key residues involved in secretion, complex-formation, virulence and immunogenicity. J Biol Chem. 280: 33953-59, (pdf-v1).

Coutanceau, E., Marsollier, L., Brosch, R., Perret, E., Goossens, P., Tanguy, M., Cole, S. T., Small, P.L., and Demangel, C. (2005) Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans : the contribution of endogenous mycolactone toxin. Cell Microbiol. 7:1187-96.

Demangel, C., Garnier, T., Rosenkrands, I., and Cole S.T. (2005) Differential effects of prior exposure to environmental mycobacteria on vaccination with Mycobacterium bovis BCG or a recombinant BCG Strain expressing RD1 antigens. Infect. Immun. 73: 2190 - 2196.

Guimaraes, B.G., Souchon, H., Honore, N., Saint-Joanis, B., Brosch, R., Shepard, W., Cole, S. T., and Alzari, P. M. (2005) Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. J Biol Chem. 280:25735-42, (pdf-v1).

Gutierrez, M.C., Brisse, S., Brosch, R., Fabre, M., Omais, B., Marmiesse, M., Supply, P., and Vincent V. (2005) Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis . PLoS Pathog 1:e5 (News-Commentary).

de Jonge, M.I., Brosch, R., Brodin, P., Demangel, C., and Cole, S.T. (2005) Tuberculosis: from genome to vaccine. Expert Rev Vaccines 4:541-51.

Majlessi, L., Brodin, P., Brosch, R., Rojas, M.J., Khun, H., Huerre, M., Cole, S.T., and Leclerc, C. (2005) Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. J Immunol. 174:3570-9.

Monot, M., Honore, N., Garnier, T., Araoz, R., Coppee, J. Y., Lacroix, C., Sow, S., Spencer, J. S., Truman, R. W, Williams, D. L., Gelber, R., Virmond, M., Flageul, B., Cho, S. N., Ji, B., Paniz-Mondolfi, A., Convit, J., Young, S., Fine, P.E., Rasolofo, V., Brennan, P. J., and Cole, S. T. (2005) On the origin of leprosy. Science. 308:1040-2.

Sinha, S., Kosalai, K., Arora, S., Namane, A., Sharma, P., Gaikwad, A.N., Brodin, P., and Cole, S.T. (2005) Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics. Microbiology. 151:2411-9.

Stinear, T.P., Hong, H., Frigui, W., Pryor, M.J., Brosch, R., Garnier, T., Leadlay, P.F., and Cole, S.T (2005) Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans. J Bact 187 :1668-1676

Villarino, A., Duran, R., Wehenkel, A., Fernandez, P., England, P., Brodin, P., Cole, S.T., Zimny-Arndt, U., Jungblut, P.R., Cervenansky, C., and Alzari P.M.(2005) Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions. J Mol Biol. 350:953-63.

Williams, A., Hatch, G.J., Clark, S.O., Gooch, K.E., Hatch, K.A., Hall, G.A., Huygen, K., Ottenhoff, T.H., Franken, K.L., Andersen, P., Doherty, T.M., Kaufmann, S.H., Grode, L., Seiler, P., Martin, C., Gicquel, B., Cole, S.T., Brodin, P., Pym, A.S., Dalemans, W., Cohen, J., Lobet, Y., Goonetilleke, N., McShane, H., Hill, A., Parish, T., Smith, D., Stoker, N.G., Lowrie, D.B., Kallenius, G., Svenson, S., Pawlowski, A., Blake, K., and Marsh, P.D. (2005) Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. Tuberculosis (Edinb).85:29-38.

2004



Banu, S., Gordon, S.V., Palmer, S., Islam, R., Ahmed, S., Alam, K.M., Cole, S.T. and Brosch, R.(2004) Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain. J. Clin. Microbiol. 42: 674-682, (pdf).

Brodin, P., Majlessi, L., Brosch, R., Smith, D., Bancroft, G., Clark, S., Williams, A., Leclerc, C., and Cole, S.T. (2004) Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens. J. Infect. Dis. 190: 115-122.

Brodin, P., Rosenkrands, I., Andersen, P., Cole, S.T. , and Brosch, R. (2004) ESAT-6 proteins: protective antigens and virulence factors? Trends Microbiol.12:500-508.

Demangel, C., Brodin, P., Cockle, P.J., Brosch, R., Majlessi, L., Leclerc, C., and Cole S.T. (2004) Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-Kilodalton culture filtrate protein and ESAT-6. Infect Immun. 72:2170-6.

Demangel C, Brosch R, Marmiesse M, Cole ST. (2004) [Use of the mycobacteria genome to develop new vaccines and therapeutic targets] Med Trop 2004;64(3):221-3.

Marmiesse, M., Brodin, P., Buchrieser, C., Gutierrez, C., Simoes, N., Vincent, V., Glaser, P., Cole, ST and Brosch, R. (2004) Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex. Microbiology 150: 483 - 496., (pdf).

Stinear, T.P., Mve-Obiang, A., Small, P.L.C., Frigui, W., Pryor, M.J., Brosch, R., Jenkin, G.A., Johnson, P.D.R, Davies, J.K., Lee, R.E., Adusumilli, S., Garnier, T., Haydock, S.F., Leadlay, P.F., and Cole, S.T. (2004) Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc Natl Acad Sci U S A. 101: 1345-1349, (pdf).

2003



Brosch, R., Marmiesse, M., and Cole, S.T.(2003) La genomique et le developpement de nouvelles strategies therapeutiques et preventives dans la lutte contre la tuberculose Medecine et Maladies Infectieuses 33, Suppl. 3, 141-146.

Kremer L, Dover LG, Morbidoni HR, Vilcheze C, Maughan WN, Baulard A, Tu SC, Honore N, Deretic V, Sacchettini JC, Locht C, Jacobs WR, Besra GS. (2003) Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria. J Biol Chem. 278:20547-54

Majlessi L, Rojas MJ, Brodin P, Leclerc C. CD8+-T-cell responses of Mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family. Infect Immun.71:7173-7.

Marsollier, L., Honore, N., Legras, P., Manceau, A.L., Kouakou, H., Carbonnelle, B., and Cole ST.(2003) Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice. Antimicrob Agents Chemother. 47:1228-32.

Marsollier, L., Prevot, G., Honore, N., Legras, P., Manceau, A.L., Payan, C., Kouakou, H. and Carbonnelle, B. (2003) Susceptibility of Mycobacterium ulcerans to a combination of amikacin/rifampicin. Int J Antimicrob Agents 22: 562-6.

Pym, A.S., Brodin, P., Majlessi, L., Brosch, R., Demangel, C., Williams, A., Griffiths, K.E., Marchal, G., Leclerc, C., and S. T. Cole (2003) Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis Nat. Med. 9:533-539,(pdf), (related news and views-pdf).

Sola, C., Rastogi, N., Gutierrez, M.C., Vincent, V., Brosch, R., and Parsons, L.(2003) Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex? J Clin Microbiol. 41:1345-6

2002


Banu, S., Honore, N., Saint-Joanis, B., Philpott, D., Prevost, M.C, and Cole S.T. (2002) Are the PE-PGRS proteins of Mycobacterium tuberculosisvariable surface antigens? Mol Microbiol 44:9-19, (full-text).

Brodin, P., Eiglmeier, K., Marmiesse, M., Billault, A., Garnier, T., Niemann, S., Cole, S.T., and Brosch, R. (2002) Bacterial Artificial Chromosome-Based Comparative Genomic Analysis Identifies Mycobacterium microtias a Natural ESAT-6 Deletion Mutant.
Infect Immun. 70:5568-5578. (fulltext), (pdf).

Brosch, R., Gordon, S.V., Marmiesse, M., Brodin, P., Buchrieser, C., Eiglmeier, K., Garnier, T., Gutierrez, C, Hewinson, G., Kremer, K., Parsons, L.M., Pym, A.S., Samper, S., van Soolingen, D., and Cole, S.T. (2002) A new evolutionary scenario for the Mycobacterium tuberculosiscomplex.
Proc Natl Acad Sci USA 99: 3684-3689.(pdf), (Supporting Table 1, Supporting Table 2).(Science-Editor's choice commentary).

Gordon, S. V, Brosch, R., Eiglmeier, K., Garnier, T., Hewinson, R. G., Cole, S. T. (2002) Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics.
Trans R Soc Trop Med Hyg. 96:1-6.

Honore N. (2002) [The Mycobacterium leprae genome: from sequence analysis to therapeutic implications] Med Trop 62:473-9.

Parsons, L. M., Brosch, R., Cole, S. T., Somoskovi, A., Loder, A., Bretzel, G., Van Soolingen, D., Hale, Y. M., Salfinger, M. (2002) Rapid and Simple Approach for Identification of Mycobacterium tuberculosis Complex Isolates by PCR-Based Genomic Deletion Analysis.
J Clin Microbiol 40:2339-2345, (pdf).

Pym, A. S, Brodin, P., Brosch, R., Huerre, M., Cole, S. T. (2002) Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovisBCG and Mycobacterium microti.
Mol Microbiol 46:709-717, (full-text).

Pym, A.S., Saint-Joanis, B., and Cole S.T. (2002) Effect of katGMutations on the Virulence of Mycobacterium tuberculosisand the Implication for Transmission in Humans. Infect Immun. 70:4955-4960, (pdf).

2001


Brosch, R., Pym, A.S., Gordon, S.V., and Cole S.T. (2001) The evolution of mycobacterial pathogenicity: clues from comparative genomics.
Trends in Microbiology 9: 452-458. (fulltext), (pdf)

Cole, S.T., K. Eiglmeier, J. Parkhill, K. D. James, N. R. Thomson, P. R. Wheeler, N. Honore, T. Garnier, C. Churcher, D. Harris, K. Mungall, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. M. Davies, K. Devlin, S. Duthoy, T. Feltwell, A. Fraser, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, C. Lacroix, J. Maclean, S. Moule, L. Murphy, K. Oliver, M. A. Quail, M.-A. Rajandream, K. M. Rutherford, S. Rutter, K. Seeger, S. Simon, M. Simmonds, J. Skelton, R. Squares, S. Squares, K. Stevens, K. Taylor, S. Whitehead, J. R. Woodward & B. G. Barrell. (2001) Massive gene decay in the leprosy bacillus.
Nature, 409: 1007-1011.

Domenech, P., Honore, N., Heym, B. and Cole, S.T. (2001) Role of OxyS of Mycobacterium tuberculosis in oxidative stress: overexpression confers increased sensitivity to organic hydroperoxides. Microbes Infect 3: 713-21 (pdf)

Eiglmeier, K., Parkhill, J., Honori, N., Garnier, T., Tekaia, F., Telenti, A., Klatser, P., James, K.D., Thomson, N.R., Wheeler, P.R., Churcher, C., Harris, D., Mungall, K., Barrell, B.G. and Cole, S.T. (2001) The decaying genome of Mycobacterium leprae. Lepr Rev 72: 387-398 (pdf).

Eiglmeier, K., Simon, S., Garnier, T. and Cole, S.T. (2001) The integrated genome map of Mycobacterium leprae. Lepr Rev 72: 462-469 (pdf).

Gordon SV, Eiglmeier K, Garnier T, Brosch R, Parkhill J, Barrell B, Cole ST, and Hewinson RG (2001) Genomics of Mycobacterium bovis. Tuberculosis (Edinb) 2001 81:1-2 157-63



Honore, N., Roche, P.W., Grosset, J.H. and Cole, S.T. (2001) A method for rapid detection of rifampicin-resistant isolates of Mycobacterium leprae. Lepr Rev 72: 441-448 (pdf).

Pym, A.S., Domenech, P., Honore, N., Song, J., Deretic, V., and Cole, S.T. (2001) Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. Mol Microbiol. 40:879-889(HTML).

Sofia, M., Maniscalco, M., Honore, N., Molino, A., Mormile, M., Heym, B. and Cole, S.T. (2001) Familial outbreak of disseminated multidrug-resistant tuberculosis and meningitis. Int J Tuberc Lung Dis 5: 551-8.

2000



Brosch, R., Gordon, S.V., Buchrieser, C., Pym, A.S., Garnier, T., Cole S.T. (2000) Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur. Comparative and Functional Genomics (Yeast) 17:111-123.(PDF).

Brosch, R., Gordon, S.V., Eiglmeier, K., Garnier, T., and Cole, S.T. (2000) Comparative genomics of the leprosy and tubercle bacilli.
Res. Microbiol. 151: 135-142. (pdf)

Brosch,R., Gordon, S.V., Pym, A., Eiglmeier, K., Garnier, T., and Cole S.T. (2000) Comparative genomics of the mycobacteria.
Int. J. Med. Microbiol. 290, 143-152., (PDF)

Cole ST, Honore N, Eiglmeier K (2000)Preliminary analysis of the genome sequence of Mycobacterium leprae. Lepr Rev. 71 Suppl:162-7.

Pym, A.S. and Brosch, R. (2000) Tools for the Population Genomics of the Tubercle Bacilli. Genome Res. 10: 1837-1839.(full-text).

1999


Brosch, R., Philipp, W.J., Stavropoulos, E., Colston, M.J., Cole, S.T., and Gordon, S.V. (1999) Genomic analysis reveals variation between Mycobacterium tuberculosis H37Rv and the attenuated M. tuberculosis H37Ra strain.Infect. Immun. 67:5768-74 (HTML).


Gordon, S.V., Brosch, R., Billault, A., Garnier, T., Eiglmeier, K. and Cole, S.T. (1999) Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays. Mol. Microbiol. 32: 643-656..(HTML)

Heym B, Saint-Joanis B, Cole ST. (1999) The molecular basis of isoniazid resistance in Mycobacterium tuberculosis. Review. Tuber Lung Dis. 79:267-71.

Saint-Joanis, B., Souchon, H., Wilming, M., Johnsson, K., Alzari, P.M. and Cole, S.T. (1999) Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis. Biochem J 338: 753-760 (HTML).

Tekaia, F., Gordon, S.V., Garnier, T., Brosch, R., Barrell, B.G. and Cole, S.T. (1999) Analysis of the proteome of Mycobacterium tuberculosis in silico. Tubercle and Lung Disease 79: 329-342, (pdf).

1998


Brosch, R., Gordon, S.V., Billault, A., Garnier, T., Eiglmeier, K., Soravito, C., Barrell, B.G. and Cole, S.T. (1998) Use of a Mycobacterium tuberculosis H37Rv Bacterial Artificial Chromosome (BAC) library for genome mapping, sequencing and comparative genomics.
Infect. Immun. 66: 2221-2229(PDF).

Buchrieser, C., Brosch, R., Bach, S., Guiyoule, A., Carniel, E. (1998) The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes. Mol Microbiol. 30:965-78(HTML)

Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S.V., Eiglmeier, K., Gas, S., Barry, C.E., III, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, A., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M.A., Rajandream, M.-A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J.E., Taylor, K., Whitehead, S. and Barrell, B.G. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature 393: 537-544. (fulltext), (pdf).

Book chapters


2009



Gutierrez, M.C., Supply, P., and Brosch, R. (2009) Pathogenomics of Mycobacteria Genome Dyn. 6:198-210.

2008


Rosenkrands, I., Bottai, D., Andersen, P., and Brosch, R. (2008), ESAT-6 and the mycobacterial ESX secretion systems. In: The Mycobacterial Cell Envelope. Daffe, M. and Reyrat, J.M. (eds). ASM Press, pp. 211-222.

Delogu, G., Cole, S. T. and Brosch, R. (2008). The PE and PPE Gene Protein Families of M. tuberculosis . In : Handbook of Tuberculosis. Kaufmann, S.H. and Rubin, E. (eds). Wiley-VHC, pp. 131-150.

2007


de Jonge, M.I., Stinear, T.P., Cole, S.T., and Brosch, R. (2007) The Mycobacteria: a Postgenomic View. In Bacterial Pathogenomics. Pallen, M.J., Nelson, K.E., and Preston, G.M. (eds). . ASM Press, Washington DC, USA, pp. 49-89.

2006


Pym, A.S., Gordon, S.V. and Brosch, R. (2006) Pathogenomics: Insighst in to Tuberculosis and related mycobacterial diseases. In Pathogenomics: Genome analysis of pathogenic microbes. Hacker, J. and Dobrindt, U. (eds). Weinheim: WILEY-VCH, pp. 211-230.

Vincent, V., Gutierrez, M.C.,and Brosch, R. (2006). Genomics and evolution of the tubercle bacilli. p. 47-64. In Series: Lung Biology in Health and Disease Volume: 219, Reichman and Hershfield's Tuberculosis: A Comprehensive International Approach, Third Edition. M.C. Raviglione (Ed).

2005


Brodin, P., Demangel, C., and Cole, S.T.(2005) Introduction to functional genomics of the Mycobacterium tuberculosis com plex. In Tuberculosis and the Tubercle Bacillus; Cole , S.T. Eisenach, K.D., McMurray, D.N. and Jacobs W.R., Jr. (eds), ASM Press, Washington DC, USA. pp143-153.

Brosch, R. and Behr, M.A. (2005) Comparative genomics and evolution of Mycobacterium bovis BCG. In Tuberculosis and the Tubercle Bacillus; Cole, S. T. Eisenach, K.D., McMurray, D.N. and Jacobs W.R., Jr. (eds), ASM Press, Washington DC, USA. pp 155-164.

Gordon, S.V. and Brosch, R. (2005) Genomics of the Mycobcacterium tuberculo sis complex and Mycobacterium leprae. In Encyclopedia of Genetics, Genomics, Pro teomics and Bioinformatics. Dunn M.J., Jorde L.B., Little P.F.R., and Subramani am S. (eds). Volume 3,Chapter 5 : Bacteria and other pathogens, Wiley.

2004


Bentley, S.D., Brosch, R., Gordon, S.V., Hopwood D.A. and Cole S.T.(2004) Genomics of Actinobacteria, the High G+C of Gram-Postive Bacteria. In Part IV: T he Evolution of Microbial Genomes, Microbial Genomes, Fraser, C.M., Read, T, and Nelson, K.E. (eds). pp. 333-360 Humana Press Inc., pp.

Expertise collective(2004) Tuberculose : Place de la vaccination dans la mantrise de la maladie. Les editions INSERM. Institut National de la Santi et de la Recherche Midicale. Full Document

2003


Brosch, R., Banu, S. and Cole, S.T. (2003) Comparative genomics of the Mycobacterium tuberculosis complex: Evolutionary insights and applications. In Tuberculosis Second Edition. Rom, W.N. and Garay, S. (eds). Philadelphia: Lippincot Williams & Wilkins, pp. 65-73.

Buchrieser, C. and Brosch, R. (2003) Vergleichende Genomforschung: Neue Einsichten in Biologie, Pathogenitaet und Evolution, am Beispiel von Listerien u nd Mykobakterien. In: Infektiologie-Aktuelle Aspekte. Jahrbuch 2003-2004. Janata , O. and Reisinger, E. (eds). pm-Verlag, Austria, pp. 165-179, 399-403.

2002


Brosch, R., Gordon, S.V., Eiglmeier, K., Garnier, T., Tekaia, F, Yeramian, E. , and Cole, S.T.: (2000) Genomics, Biology, and Evolution of the Mycobac terium tuberculosis Complex. In: Molecular Genetics of Mycobacteria. Hatfull , F., and Jacobs, W.R. Jr., (eds). Washington DC: American Society for Microbiology, pp. 19-36.

1999



Gordon, S.V., Eiglmeier, K., Brosch, R., Garnier, T., Honori, N., Barrell, B. G. and Cole, S.T. (1999) Genomics of Mycobacterium tuberculosis and Mycobact erium leprae. In Mycobacteria: Molecular biology and virulence. Ratledge, C. and Dale, J.W. (eds). Oxford: Blackwell Science, pp. 93-109.

1998



Telenti, A., Honoré, N. and Cole, S.T. (1998) Detection of mutations in mycobacteria by PCR-SSCP (Single-strand conformation polymorphism). In Mycobacteria protocols. Parish, T. and Stoker, N.G. (eds). Totowa, NJ: Humana Press Inc., pp. 423-430.


Please address questions and comments to rbrosch@pasteur.fr

Institut Pasteur