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Evolutionary scheme of the members of the M. tuberculosis complex




A new evolutionary scenario for the Mycobacterium tuberculosiscomplex.
Proc Natl Acad Sci USA (2002) 99: 3684-3689.(pdf), Web-based supporting material: (Primer-Table 1.pdf, RD-Table 2.pdf ). (Science-Editor's choice commentary).




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Recent insights into the evolution of the Mycobacterium tuberculosis complex (as shown in Fig. S1, above) are discussed in a recent article in "Molecular Microbiology", which is freely available at the website of the journal: Boritsch, E.C., Supply, P., Honore, N., Seeman, T., Stinear, T.P., and Brosch, R. (2014) A glimpse into the past and predictions for the future: The molecular evolution of the tuberculosis agent. Mol Microbiol. , PubMed PMID: 25039682 .

In a collaborative project with the team of Carlos Martin (University of Zaragoza, Spain) and the team of Christophe Guilhot (IPBS Toulouse, France) we have recently identified a few mutations in a major virulence regulator (PhoPR) of M. tuberculosis, which seem to have shaped the evolution of certain M. tuberculosis complex members in relation to their specific hosts, as described below: Gonzalo-Asensio, J., Malaga, W., Pawlik, A., Astarie-Dequeker, C., Passemar, C. , Moreau, F., Laval., F., Daffe, M., Martin, C., Brosch, R., and Guilhot C. (2014) Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator. Proc Natl Acad Sci U S A. 111:11491-6 .

A previous study on human isolates from East Africa named Mycobacterium canettii enabled the probable progentor species of the M. tuberculosis complex to be identified and characterized. Further information on this study is avalable via the open access article:
Gutierrez, M.C., Brisse, S., Brosch, R., Fabre, M., Omais, B., Marmiesse, M., Supply, P., and Vincent V. (2005) Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis . PLoS Pathog 1: e5 (pdf) (News-Commentary ).

This work on phylogenetically early branching tubercle bacilli has be largely extended by determining and analysing the genome sequences of various M. canetti strains.
Further information on this study is available via the open access article: Supply, P., Marceau, M., Mangenot, S., Roche, D., Rouanet, C., Khanna, V., Majlessi, L., Criscuolo, A., Tap, J., Pa wlik, A., Fiette, L., Orgeur, M., Fabre, M., Parmentier, C., Frigui, W., Simeone, R., Boritsch, E.C., Debrie, A.S., Willery, E., Walker, D., Quail, M.A., Ma, L., Bouchier, C., Salvignol, G., Sayes, F, Cascioferro, A., Seemann, T., Barbe, V., Locht, C., Gutierrez, M.C., Leclerc, C., Bentley, S.D., Stinear, T.P., Brisse, S., Medigue, C., Parkhi ll, J., Cruveiller, S., and Brosch, R. (2013) Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Nature Genetics 45:172-9 . (News-Commentary )


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