Institut Pasteur
25 Rue du Docteur Roux
75724 Paris Cedex 15
Tel: 33 (0)1 45 68 88 16
Fax : 33 (0)1 45 68 87 90
Mme Sylvana Thépaut

IV - A new regulation pathway for iron acquisition
(Francis Biville)

The two components system YgiX/YgiY is present in many Gram negative bacteria. YgiY shares homologies with two components sensor kinases and YgiX with two components transcriptional activators. It appears to be involved in regulation of several E. coli functions such as motility, biofilm formation and iron acquisition. We have shown that inactivation of ygiY allows iron bound to pyrophosphate utilization even in the absence of enterochelin suggesting that YgiY/ YgiX regulates a yet not identified iron transport system. YgiY has a EXXE motif present on several iron binding proteins. We are presently searching whether YgiY binds radioactive iron 55.

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