Complete Publications List of the Mouse Molecular Genetics Unit since 2000

Merzouk S, Deuve JL, Dubois A, Navarro P, Avner P, Morey C. Lineage-specific regulation of imprinted X inactivation in extraembryonic endoderm stem cells. Epigenetics Chromatin. 2014 Jun 20;7:11. doi: 10.1186/1756-8935-7-11.

Lebailly B., He C., Rogner U.C. Linking the circadian rhythm gene Arntl2 to interleukin 21 expression in type 1 diabetes. Diabetes. 2014 Jun;63(6):2148-57. doi: 10.2337/db13-1702.

Dubois A, Deuve JL, Navarro P, Merzouk S, Pichard S, Commere PH, Louise A, Arnaud D, Avner P, Morey C. Stem Cells. Spontaneous reactivation of clusters of X-linked genes is associated with the plasticity of X-inactivation in mouse trophoblast stem cells. Stem Cells. 2013 Oct 1. doi: 10.1002/stem.1557.

Attia M, Rachez C, Avner P, Rogner UC. Nucleosome assembly proteins and their interacting proteins in neuronal differentiation. Archives of Biochemistry and Biophysics 2012 Sep 29. pii: S0003-9861(12)00356-6. doi: 10.1016/ (invited review)


Attia M, Frster A, Rachez C, Freemont P, Avner P, Rogner UC. Interaction between nucleosome assembly protein 1-like family members. J Mol Biol. 2011 Apr 15;407(5):647-60. Epub 2011 Feb 17. PubMed PMID: 21333655.

Avner P. Functional mouse genomics. Introduction. Methods. 2011 Feb;53(2):111-2. PubMed PMID: 21284973.

Chureau C, Chantalat S, Romito A, Galvani A, Duret L, Avner P, Rougeulle C. Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. Hum Mol Genet. 2011 Feb 15;20(4):705-18. Epub 2010 Nov 30. PMID: 21118898

Clerc P, Avner P. New lessons from random X-chromosome inactivation in the mouse. J Mol Biol. 2011 May 27;409(1):62-9. Epub 2011 Feb 15. PubMed PMID: 21329697.

Deuve JL, Avner P. The coupling of X-chromosome inactivation to pluripotency. Annu Rev Cell Dev Biol. 2011 Nov 10;27:611-29. Epub 2011 Jul 29.

Morey C, Avner P. Genetics and epigenetics of the X chromosome. Ann N Y Acad Sci. 2010 Dec;1214:E18-33. doi: 10.1111/j.1749-6632.2010.05943.x. Review. PubMed PMID: 21382199.

Morey C, Avner P. The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever. PLoS Genet. 2011 Jul;7(7):e1002212. Epub 2011 Jul 21.

Rogner U. Use of Congenic Mouse Strains for Gene Identification in Type 1 Diabetes. in "Type 1 Diabetes / Book 1", INTECH ISBN 978-953-307-362-0.


Navarro P, Oldfield A, Legoupi J, Festuccia N, Dubois A, Attia M, Schoorlemmer J, Rougeulle C, Chambers I, Avner P. Molecular coupling of Tsix regulation and pluripotency. Nature. 2010 Nov 18;468(7322):457-60. PubMed PMID: 21085182.

Avner PR. Sweetness and light: perspectives for rodent models of type 1 diabetes. Dis Model Mech. 2010 Jul-Aug;3(7-8):426-9. Epub 2010 Jun 2. PubMed PMID: 20519570.

Chow JC, Ciaudo C, Fazzari MJ, Mise N, Servant N, Glass JL, Attreed M, Avner P, Wutz A, Barillot E, Greally JM, Voinnet O, Heard E. LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation. Cell. 2010 Jun 11;141(6):956-69. PubMed PMID: 20550932.

He CX, Prevot N, Boitard C, Avner P, Rogner UC. Inhibition of type 1 diabetes by upregulation of the circadian rhythm related Aryl hydrocarbon receptor nuclear translocator-like protein 2. Immunogenetics. 2010 Sep;62(9):585-92. Epub 2010 Jul 30. PubMed PMID: 20676886.

He CX, Avner P, Boitard C, Rogner UC. Downregulation of the circadian rhythm related gene Arntl2 suppresses diabetes protection in Idd6 NOD.C3H congenic mice. Clin Exp Pharmacol Physiol. 2010 Sep 29. doi: 10.1111/j.1440-1681.2010.05451.x. [Epub ahead of print] PubMed PMID: 20880188.

Maenner S, Blaud M, Fouillen L, Savoye A, Marchand V, Dubois A, Sanglier-Cianférani S, Van Dorsselaer A, Clerc P, Avner P, Visvikis A, Branlant
2-D structure of the A region of Xist RNA and its implication for PRC2 association. PLoS Biol. 2010 Jan;8(1):e1000276. Epub 2010 Jan 5. PubMed PMID: 20052282; PubMed Central PMCID: PMC2796953.

Navarro P, Avner P. An embryonic story: analysis of the gene regulative network controlling Xist expression in mouse embryonic stem cells. Bioessays. 2010 Jul;32(7):581-8. PubMed PMID: 20544740.


Billot K, Parizot C, Arrouss I, Mazier D, Debre P, Rogner UC, Rebollo A. Differential aiolos expression in human hematopoietic subpopulations. Leuk Res. 2010 Mar;34(3):289-93. Epub 2009 Jun 21.

Rheault MN, Kren SM, Hartich LA, Wall M, Thomas W, Mesa HA, Avner P, Lees GE, Kashtan CE, Segal Y. X-inactivation modifies disease severity in female carriers of murine X-linked Alport syndrome. Nephrol Dial Transplant. 2009 Nov 9. [Epub ahead of print] PubMed PMID: 19854849.

Navarro P, Chantalat S, Foglio M, Chureau C, Vigneau S, Clerc P, Avner P, Rougeulle C. A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre. Epigenetics Chromatin. 2009 Jul 20;2(1):8.

Navarro P, Avner P. When X-inactivation meets pluripotency: an intimate rendezvous. FEBS Lett. 2009 Jun 5;583(11):1721-7.


Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, Rougeulle C, Avner P. Molecular coupling of Xist regulation and pluripotency. Science. 2008 Sep 19;321(5896):1693-5.

Vallois, D., Gagnerault, M.C., Rogner U.C., Avner P., Boitard, C., Benlagha, K., Herbelin, A., Lepault F. (2008). Influence of a non NKC region of chromosome 6 on CD4+ iNKT cell homeostasis. Journal of Immunology, Aug 1;181(3):1753-9.

Rogner U.C. and Avner P. (2008) Use of congenic mouse strains for candidate disease gene identification in complex traits. Sourcebook of Models for Biomedical Research. Humana Press, editor M. Conn, (capter 59) 575-581.


Attia M., Rachez C., De Pauw A., Avner P. and Rogner U.C. (2007) Nap1l2 promotes histone acetylation activity during neuronal differentiation. Molecular and Cellular Biology, in press, Mol. Cell. Biol. doi:10.1128/MCB.00789-07

Vallois D., Grimm C.H., Avner, P. Boitard, C., Rogner U.C. (2007) The type 1 diabetes locus Idd6 controls Toll-like receptor 1 expression. Journal of Immunology, 179(6):3896-903.


Bourdet, A., Ciaudo, C., Zakin, L., Elalouf, J.M., Rusniok, C., Weissenbach, J. and Avner, P. (2006) A SAGE approach to identify novel trans-acting factors involved in the X-inactivation process. Cytogenet. Genome Res. 114(2):130.

Ciaudo C, Bourdet A, Cohen-Tannoudji M, Dietz HC, Rougeulle C, Avner P. (2006) Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation. PLoS Genet. (6):e94.

Clerc P, Avner P. (2006) Random X-chromosome inactivation: skewing lessons for mice and men. Curr Opin Genet Dev. (3):246-53

Duret L, Chureau C, Samain S, Weissenbach J, Avner P. (2006) The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene.Science. 312(5780):1653-5.

Hung, M.S., Avner, P., Rogner U.C. (2006) Identification of the transcription factor Arntl2 as a candidate gene for the type 1 diabetes locus Idd6. Hum. Mol. Genet. 15(18):2732-42.

Morin, J, Boitard, C, Vallois, D, Avner, P, Rogner UC (2006). Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction. Mammalian Genome Nov;17(11):1105-12.

Rogner, U.C., Lepault, F., Gagnerault, M.C., Vallois, D., Morin, J., Avner, P., and Boitard, C. (2006) The diabetes type 1 locus Idd6 modulates activity of CD4+CD25+ regulatory T cells. Diabetes 55: 186-192.

Vigneau S, Augui S, Navarro P, Avner P, Clerc P. (2006) An essential role for the DXPas34 tandem repeat and Tsix transcription in the counting process of X chromosome inactivation. Proc Natl Acad Sci U S A. 103(19):7390-5.


Kunath, T., Arnaud, D., Uy, G.D., Okamoto, I., Chureau, C., Yamanaka, Y., Heard, E., Gardner, R.L., Avner, P. and Rossant, J. (2005) Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development 132(7):1649-61.

Navarro, P., Pichard, S., Ciaudo, C., Avner, P. and Rougeulle, C. (2005) Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation. Genes Dev. 15: 1474-84.

Okamoto I, Arnaud D, Le Baccon P, Otte AP, Disteche CM, Avner P, Heard E. (2005) Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice.Nature. 2005 Nov 17;438(7066):369-73. Epub 2005 Oct 16.

Starke H., Karst C., Trifonov V., Claussen U., Mrasek K., Michel S., Avner P. and Liehr T. (2005) Molecular cytogenetic characterization of the mouse cell line WMP2 by spectral karyotyping (SKY) and multicolor banding (mcb) applying murine probes. Europ J Hum Genet, Vol 13 Suppl. 1, p 154.

Trifonov, V., Karst, C., Claussen, U., Mrasek, K., Michel, S., Avner, P. and Liehr, T. (2005) Microdissection dérive murine mcb probes from somatic cell hybrides. J. Histochem. Cytochem. 53: 791-2.


Avner, P, Jauwerx , J, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet S, Chambon S., Cox R, Davidson D, Davies K, Duboule D, Forejt J, Granucci F, Hastie N, Hrabé de Angelis M, Jackson I, Kioussis D, Kollias G, Lathrop M, Lendahl U, Malumbres M, von Melchner H, Müller W, Partanen J, Ricciardi-Castagnoli P, Rigby P, Rosen B, Rosenthal N, Skarnes B, Stewart AF, Thornton J, Tocchini-Valentini G, Wagner E, Wahli W, Wurst W (2004) The European dimension for the mouse genome mutagenesis programme. Nature Genetics, 36: 925-927.

Mise, N and Avner, P. (2004) BAC modification using a RecA expressing shuttle vector system. Methods Mol Biol., 256 : 77-87.

Morey, C, Navarro, P., Debrand, E., Avner, P., Rougeulle, C. and Clerc, P. (2004) The region 3’ to Xist mediates the counting function of X chromosome inactivation and targets H3 Lys-4 dimethylation to within the Xist gene. EMBO J. 23: 594-604.

Morey, C. and Avner P. (2004) Employment opportunities for non-coding RNAs. FEBS 567: 27-34..

Rougeulle, C., Chaumeil J., Sarma, K., Sinkai, Y., Allis, D. Reinberg, D., Avner, P. and Heard. E. (2004) Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol. 24: 5475-84.

Rougeulle, C. and Avner, P. (2004) The role of antisense transcription in the regulation of X-inactivation Current Topics in Develop. Biol. 63: 61-94.


Clerc, P. and Avner, P. (2003) Multiple elements within the Xic regulate random X inactivation in mice. Seminars in Cell and Developmental Biology, 14: 85-92.

Flaherty, L., Abiola, O., Angel, J.M., Avner, P. et al (Members of the Complex Trait Consortium) (2003) The nature and identification of quantitative trait loci : a community’s view. Nature Genetics 4: 911-916.

Grimm, C.H., Rogner U.C. and Avner, P. (2003) Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6. Autoimmunity, 36: 241-246.

Rogner, U.C. and Avner, P. (2003) Congenics: cutting tools for complex immune disorders. Nature Reviews Immunology, 3: 243-252.

Rougeulle, C, Navarro, P. and Avner, P. (2003) Promoter restricted H3 Lys 4 di-methylation is an epigenetic mark for monoallelic expression. Human Mol. Genetics, 12: 3343-3348.

Rougeulle, C. and Avner, P. (2003) Controlling X inactivation in mammals : what does the centre hold ? Sem. Cell Dev. Biol. 14: 331-340.

Sousa-Nunes, R., Rana, A., Kettleborough, R., Brickman, J.M., Clements, M., Forrest, A., Grimmond, S., Avner, P., Smith, J.C., Dunwoodie, S.L. and Beddington, R.S. (2003) Characteristing embryonic gene expression patterns in the mouse using non-redundant sequence-based selection. Genome Research, 13: 2609-2620.


Avner, P. (2002) A toolbox for a small mammal. Mamm. Genome, 13: 125-126

Chureau, C., Prissette, M., Bourdet, A., Barbe, V., Cattolico, L., Jones, L., Eggen, A., Avner, P. and Duret, L. (2002) Comparative sequence analysis of the X-inactivation centre region in mouse, human and bovine. Genome Res., 12: 894-908.

Rogner, U.C., Danoy, P., Matsuda, F., Moore, G., Stanier, P., and Avner, P. (2002) SNPs in the CpG island of NAP1L2: a possible link between DNA methylation and neural tube defects? Am. J. Med. Genet., 110: 208-214.

Rougeulle C. and Heard E. (2002) Antisense RNA in imprinting : Spreading silence through Air? TIGS, 18: 434-436.


Avner, P. and Heard, E. (2001) X-chromosome inactivation : counting, choice and initiation. Nat. Genet. Reviews, 2: 59-67.

Avner, P., Bruls, T. , Poras, I. , Eley, L., Gas, S., Ruiz, P., Wiles, M.V., Sousa - Nunes, R., Kettleborough, R., Rana, A., Morrisette, J., Bentley, L., Goldsworthy, M., Haynes, A., Herbert, E., Southam, L., Lehrach, H., Weissenbach, J., Manenti, G., Rodriguez-Tome, P., Beddington, R., Dunwoodie, S., and Cox, R. (2001) A radiation hybrid transcript map of the mouse genome. Nat. Genet., 29: 194-200.

Heard, E, Rougeulle, C., Arnaud, D., Avner, P., Allis, D and Spector, D (2001) Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X-inactivation. Cell, 107: 727-738.

Morey, C., Arnaud, D., Avner, P. and Clerc, P. (2001) Tsix-mediated repression of Xist accumulation is not sufficient for normal random X-inactivation Hum. Mol. Genet., 10: 1403-1411.

Prissette, M., El-Maarri, O., Arnaud, D., Walter, J. and Avner, P. (2001) Methylation profiles of the DXPas34 locus during the onset of X-inactivation. Hum. Mol. Genet., 10: 31-38.

Rogner, U., Boitard, C, Morin, J., Melanitou, E., and Avner, P. (2001) Three genetically interacting loci on mouse chromosome 6 influence onset and final incidence of type I diabetes in NOD.C3H congenic strains. Genomics, 74: 163-171.


Al-Ubaidi, M R., White, T.W., Ripps, H., Poras, I., Avner, P., Gomes, D., and Bruzzone, R. (2000) Functional properties, dévelopmental regulation, and chromosomal localization of murine connexin 36, a gap-junctional protein expressed preferentially in retina and brain. J. Neuroscience Res., 59: 813-826.

Clerc, P. and Avner, P. (2000) Reprogramming X inactivation. Science, 290: 1518.

Depatie, C., Lee, S.H., Stafford, A., Avner, P., Belouchi, A., Gros, P. and Vidal, S.M. (2000) Sequence-ready BAC contig, physical and transcriptional map of a 2 Mb region overlapping the mouse chromosome 6 host resistance locus Cmv1. Genomics, 66: 161-174.

Heard, E. and Avner, P. (2000) Trans-Siberian X press report. Trends Genet., 16: 64-65.

Rogner, U., Spyropoulos, D.D., Le Novère, N., Changeux, J.P. and Avner P. (2000) Control of neurulation by the nucleosomal assembly protein 1l2. Nat. Genet., 25: 431-435.