Céline Morey

 
Céline’s research aims at understanding the plasticity of chromatin fibres and the dynamics of gene association-dissociation with specific nuclear compartments in each cell of the pre-implantation embryo using X-chromosome inactivation as a model for large scale epigenetic reprogramming.
During her PhD in the Mouse Molecular Genetics Unit, Céline characterised some of the genomic elements involved in the initiation step of random X-chromosome inactivation using targeted mutagenesis in mouse embryonic stem (ES) cells. Then she did a three year postdoctoral training in Wendy Bickmore’s lab in Edinburgh where she studied the nuclear re-organisation associated with the activation of Hox gene clusters during mouse development using 3-dimensional fluorescence in situ hybridisation techniques (3D FISH). Back to the lab she got a permanent position with the INSERM in 2008.

 

List of publications

Morey C, Kress C, Bickmore WA (2009) Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to upregulate gene expression. Genome Res.
Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, Rougeulle C, Avner P. (2008) Molecular coupling of Xist regulation and pluripotency. Science, 321:1693-5.
Morey C, Da Silva NR, Kmita M, Duboule D, Bickmore WA. (2008) Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd. J Cell Sci., 121:571-7.
Morey C, Da Silva NR, Perry P, Bickmore WA. (2007) Nuclear reorganisation and chromatin decondensation are conserved, but distinct, mechanisms linked to Hox gene activation. Development. 134:909-19.
Morey C, Bickmore W. (2006) Sealed with a X. Nat Cell Biol., 8:207-9
Morey C, Avner P. (2004) Employment opportunities for non-coding RNAs. (2004) FEBS Lett., 567:27-34.
Morey C, Navarro P, Debrand E, Avner P, Rougeulle C, Clerc P. (2004) The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene. EMBO J., 23:594-604.
Morey C, Arnaud D, Avner P, Clerc P. (2001) Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation. Hum Mol Genet., 10:1403-11.