All selected participants have by now been informed by email.
We have received many more applications than places. Thus, very unfortunately, the large majority of applications could not be considered.
NMR has established itself as the second method for structure determination of
biological macromolecules and is unique in extracting dynamical information on
biological macromolecules over a large range of timescales. In the past, there have been lecture courses on NMR theory, but not on teaching practical aspects in a hands-on fashion. The course will try to fill this gap. We see the practical course as complementary to the "Advanced NMR" EMBO lecture course held in previous years
M. Nilges , M. Sattler
September 12-19, 1999
EMBL , Meyerhofstr. 1, D-69117 Heidelberg, Germany
Christian Griesinger, Frankfurt
Stephan Grzesiek, Duesseldorf
Peter Guentert, Zuerich
Ernest Laue, Cambridge
Maria Macias, EMBL Heidelberg
Lawrence McIntosh, Vancouver
Michael Nilges, EMBL Heidelberg
Michael Sattler, EMBL Heidelberg
Juergen Schleucher, Umea
Nico Tjandra, Bethesda
Gert Vriend, EMBL HEidelberg
Geerten Vuister, Nijmegen
The course is intended to cover the experimental and computational aspects of characterizing structure and dynamics of a biological macromolecules by modern heteronuclear experiments.
The emphasis will be on setting up experiments on the spectrometer (optimizing
parameters, pulse programs), on processing and analyzing the NMR data and on
structure calculations. It is impossible to also teach all the necessary
theoretical background of modern NMR experiments in a few days. Therefore, the
course is aimed at PhD students and postdocs who have some working knowledge of
NMR theory, (e.g., product operator formalism), and who understand the basic
principles of NMR pulse sequences. Possible candidates should have the level of
knowledge of students that have participated in a past "Advanced NMR" EMBO
lecture course on NMR theory organized by Kaptein, Oschkinat and Griesinger.
Every subject will be introduced by lectures (1h each day).
The pulse sequences and the programs used for data analysis will be
demonstrated (1h following the morning lecture).
The remainder of the day will be devoted to practical work either on the
spectrometer, or on computers for analyzing NMR data and performing structure
The NMR experiments will be organized in such a way that each participant (in
groups of 2-3) will be able to set up the relevant experiments during the week
Data analysis, assignment and structure calculation will be performed by the
participants in small groups distributed throughout the week.
A sample project will be available for performing the NMR experiments, data
analysis, assignment and structure calculation. For each step, pre-recorded and
pre-processed data will be available. We will try to make it possible for participants to bring their own data.
We gratefully acknowledge contributions from Bruker and Martek