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2013
Montaudouin, C., Anson, M., Hao, Y., Duncker, S.V., Fernandez, T., Gaudin, E., Ehrenstein, M., Kerr, W.G., Colle, J.-H., Bruhns, P., Daëron, M. & Freitas, A.A. Quorum sensing contributes to activated IgM-secreting B cell homeostasis. J. Immunol. 190 : 106-114 (2013)

Mahevas, M., Patin, P., Huetz, F., Descatoire, M., Cagnard, N., Bole-Feysot, C., Le Gallou, S., Khellaf, M., Fain, O., Boutboul, D., Galicier, L., Ebbo, M., Lambotte, O., Hamidou, M., Bierling, P., Godeau, B., Michel, M., Weill, J.-C. & Reynaud, C.-A. B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. J. Clinical Invest. 123 : 432-442 (2013)

2012
Gomes, J., Magalhaes, A., Michel, V., Amado, I.F., Aranha, P., Ovesen, R.G., Hansen, H.C.B., Gärtner, F., Reis, C.A. & Touati, E. Pteridium aquilinum and its ptaquiloside toxin induce DNA damage response in gastric epithelial cells, a link with gastric carcinogenesis. Toxicol. Sciences 126 : 60-71 (2012)

Almeida, A.R.M., Amado, I.F., Reynolds, J., Berges, J., Lythe, G., Molina-Paris, C. & Freitas, A.A. Quorum-sensing in CD4+ T cell homeostasis : a hypothesis and a model. Frontiers in Immunol. 3, article 125 : 1-15 (2012)

Garcia, S. &. Freitas A.A. Humanized mice : current states and perspectives. Immunol. Letters 146 : 1-7 (2012)

2011
Lochner, M., Bérard, M., Sawa, S., Hauer, S., Gaboriau-Routhiau, V., Fernandez, T.D., Snel, J., Bousso, P., Cerf-Bensussan, N. & Eberl, G. Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th 17 cells. J. Immunol. 186 : 1531-1537 (2011)

Zaragoza, B., Evaristo, C., Kissenpfennig, A., Libri, V., Malissen, B., Rocha, B., Freitas, A.A. & Almeida, A.R.M. Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8+ TCM and TEM cell pools. PLoS ONE 6 : e17423 (2011)

Guergnon, J., Godet, A.N., Galioot, A., Falanga, P.B., Colle, J.-H., Cayla, X. & Garcia, A. PP2A targeting by viral proteins : a widespread biological strategy from DNA/RNA tumor viruses to HIV-1 Biochim. Biophys. Acta 1812 : 1498-1507 (2011)

Pere, H., Montier, Y., Bayri, J., Quintin-Colonna, F., Merillon, N., Dransart, E., Badoual, C., Gey, A., Ravel, P., Marcheteau, E., Batteux, F., Sandoval, F., Adotevi, O., Chiu, C., Garcia, S., Tanchot, C., Lone, Y.C., Ferreira, L.C., Nelson, B.H., Hanahan , D., Fridman, W.H., Johannes, L. & Tartour, E. A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens. Blood 118 : 4853-4862 (2011)

Bouvier I., Jusforgues-Saklani H., Lim A., Lemaître F., Lemercier B., Auriau C., Nicola M.-A., Leroy S. Law H. K., Bandeira A., Moon J. J., Bousso P. & Albert M.L. Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery. Front. Immunol. 2 : 1-18 (2011)

2010
Montaudouin, C., Boucontet, L., Mailhe-Lembezat, M.-P., Mariotti-Ferrandiz, M.-E., Louise, A., Six, A., Freitas, A.A. & Garcia, S. Endogenous TCR recombination in TCR Tg single Rag-deficient mice uncovered by robust in vivo T cell activation and selection. PLoS ONE 5 : e10238 (2010)

Lalanne A.I., Moraga I., Hao Y., Pereira J.P., Alves N.L., Huntington N.D., Freitas A.A., Cumano A. & Vieira P. CpG inhibits Pro-B cell expansion through a cathepsin B-dependent mechanism. J. Immunol. 184 : 5678-5685 (2010)

2009
Thiriot Aude, Drapier Anne-Marie, Mémet Sylvie, Fitting Catherine, Sturny-Leclere Aude, Cavaillon Jean-Marc, Cazenave Pierre-André, Freitas Antonio A. & Rueff-Juy Dominique. Wild-derived mouse strains, a valuable model to study B cell responses. Mol. Immunol. 46 : 601-612 (2009)

Freitas, A.A. & Rocha B. Homeostasis of naive T cells : the Foxo that fixes. Nature Immunol. 10 : 133-144 (2009)

Leitao, C., Freitas, A.A. & Garcia, S. The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool. J Immunol. 182 : 5232-5239 (2009)

Rose T, Lambotte O, Pallier C, Delfraissy JF & Colle JH. Identification and Biochemical Characterization of Human Plasma Soluble Interleukin-7 Receptor: Lower Concentrations in HIV-1-infected patients. J. Immunol. 182: 7389-7397 (2009)

2008
Lampropoulou, V., Hoehlig, K., Roch, T., Neves, P., Calderon Gomez, E., Sweenie, C.H., Hao, Y., Freitas, A.A., Steinhoff, U., Anderton, S.M. & Fillatreau. S.TLR- activated B cells suppress T cell-mediated autoimmunity. J. Immunol. 180 : 4763-4773 (2008)

Thiriot, A., Freitas, A.A. & Rueff-Juy D. Peritoneal B-cell subsets in the genus Mus : their role in innate immunity. Crit Rev Immunol. 28 : 341-361 (2008)

2007
Sanchez-Guajardo, V., Tanchot, C., O’Malley, J.T., Kaplan, M.H., Garcia, S. & Freitas, A.A. Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6. J. Immunol. 178 : 7550-7556 (2007)

2006
De la Coste, A. & Freitas, A.A. Notch signaling : distinct ligands induce specific signals during lymphocyte development and maturation. Immunol letters 102 : 1-9 (2006)

Mascarell, L., Auger, R., Kanellopoulos, J.M. & Truffa-Bachi, P. The usage of alternative splice sites in mus musculus synaptotagmin-like 2 gene is modulated by cyclosporin A and FK506 in T-lymphocytes. Mol. Immunol. 43 : 1846 – 1854 (2006)

Almeida ARM, Zaragoza B. & Freitas AA. Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2 producing cells. J. Immunol. 177 : 192-200 (2006)

Hao Y., Legrand L. & Freitas AA. The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J. Exp. Med. 203 : 1643-1649 (2006)

Almeida, ARM., Zaragoza, B. & Freitas A.A. Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells. Int. Immunol. 18 : 1607-1613 (2006)

2005
Wildin, R.S. & Freitas, A. IPEX and Foxp3 : clinical and research perspectives. J. Autoimmunity 25 : 56-62 (2005)

Sanchez-Guajardo, V., Borghans, J.A.M., Marquez, M.-E., Garcia, S. & Freitas, A.A. Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphopenia-driven proliferation. J. Immunol. 174 : 1178-1187 (2005)

De La Coste, A., Six, E., Fazilleau, N., Mascarell L., Legrand, N., Mailhe, M.-P., Cumano, A., Laabi, Y. & Freitas, A.A. In vivo and in absence of a thymus the enforced expression of the Notch ligands Delta-1 or Delta-4 promotes T cell development with specific unique effects. J. Immunol. 174 : 2730-2737 (2005)

Almeida, A.R.M., Rocha, B., Freitas, A..A & Tanchot, C. Homeostasis of T cell numbers : from thymus production to peripheral compartmentalization and the indexation of regulatory T cells. Sem. Immunol. 17 : 239-249 (2005)

Agenes, F., Bosco, N., Mascarell, L., Fritah, S. & Ceredig, R. Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cells. Immunology 115 : 179-188 (2005)

Ghiringhelli, F., Ménard, C., Terme M., Flament, C., Taieb, J., Chaput, N., Puig, P.E., Novault, S., Escudier, B., Vivier, E., Lecesne, A., Robert, C., Blay, J.-Y., Caillat-Zucman, S., Freitas, A., Tursz, T., Wagner-Ballon, O., Capron, C., Vainchencker, W., Martin, F. & Zitvogel, L. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-b-dependent manner. J. Exp. Med. 202 : 1075-1085 (2005)

Marquez M.-E., Ellmeier W., Sanchez-Guajardo V., Freitas A.A., Acuto O. & Di Bartolo V. T cell sensory adaptation dependent on TCR avidity for self-antigens. J. Immunol. 175 : 7388-7397 (2005).

2004
Gaudin, E., Rosado, M., Agenes, F., McLean, A. & Freitas, A.A. B-cell homeostasis, competition, resources, and positive selection by self-antigens. Immunol. Rev. 197 : 102-115 (2004)De Boer R.J., Borghans, J.A.M., van Boven, M., Kesmir, C. & Weissing, F.J. Heterozygote advantage fails to explain the high degree of polymorphism of the MHC. Immunogenetics 55 : 725-731 (2004)

Borghans, J.A.M., Beltman, J.B. & De Boer, R.J. MHC polymorphism under host-pathogen coevolution. Immunogenetics 55 : 732- 739 (2004)

Gaudin, E., Hao, Y., Rosado, M.M., Chaby, R., Girard, R. & Freitas, A.A. Positive selection of B cells expressing low densities of self-reactive BCRs. J. Exp. Med. 199 : 843-853 (2004)

Mascarell, L., Auger, R., Alcover, A., Ojcius, D.M., Jungas, T., Cadet-Daniel, V., Kanellopoulos, J.M. & Truffa-Bachi, P. Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cells. J. Biol. Chem. 279 : 10556-10563 (2004)

Mascarell, L. & Truffa-Bachi, P. T lymphocyte activation initiates the degradation of the CD62L encoding mRNA and increases the transcription of the corresponding gene. Immunol. Letters 94 : 115-122 (2004) Schlecht, G., Garcia, S., Escriou, N., Freitas, A.A., Leclerc C. & Dadaglio, G. Murine plasmacytoid dendritic cells Cs induce effector/memory CD8+ T cells responses in vivo after viral stimulation. Blood 104 : 1808-1815 (2004)

2003
Borghans, J.A.M., Noest, A.J. & De Boer R.J. Thymic selection does not limit the individual MHC diversity. Eur. J. Immunol. 33 : 3353-3358 (2003)

Mascarell, L. & Truffa-Bachi P. New aspects of cyclosporin A mode of action: from gene silencing to gene up-regulation. Mini Rev. Med. Chem. 3 : 207-216 (2003)

2002
Borghans, J.A.M. & De Boer, R.J. Memorizing innate instructions requires a sufficiently specific adaptive immune system. Int. Immunol. 14 : 525-532 (2002)

Freitas, A. & Chen J. Introduction : regulation of lymphocyte homeostasis. Microbes & Infec. 4 : 529-530 (2002)

Almeida, A.R.M., Legrand, N., Papiernick, M. & Freitas, A.A. Homeostasis of peripheral CD4+ T cells : IL-2Ra and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169 : 4850-4860 (2002)

Haller, C., Fillatreau, S., Hoffmann, R. & Agenes, F. Structure, chromosomal localization and expression of the mouse regulator of G-protein signaling10 gene (mRGS10). Gene 297 : 39-49 (2002)

Mascarell, L. & Truffa-Bachi, P. Cyclosporin A therapy differently affects immunological-relevant gene expression following immunization. Immunology Letters 84 : 137-143 (2002)

2001
Li, F., Jin, F., Freitas, A.A., Szabo, P. & Weksler, M.E. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur. J. Immunol. 31 : 500-505 (2001)

Almeida, A.R.M., Borghans, J.A.M. & Freitas, A.A. T cell homeostasis : thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J. Exp. Med.194 : 591-599 (2001)

Legrand, N. & Freitas A.A. CD8+ T lymphocytes in double ab TCR transgenic mice. I. TCR expression and thymus selection in the absence or in the presence of self-antigen. J. Immunol. 167 : 6150-6157 (2001)

Legrand, N. & Freitas A.A. CD8+ T lymphocytes in double ab TCR transgenic mice. II. Competitive fitness of dual ab TCR CD8+ T lymphocytes in the peripheral pools. J. Immunol. 167 : 6158-6164 (2001)

De Boer, R.J., Freitas, A.A & Perelson, A.S. Resource competition determines selection of B cell repertoires. J. Theor. Biol. 212 : 333-343 (2001)

Kourilsky, P. & Truffa-Bachi P. Cytokines fields and the polarization of the immune response. Trends in Immunol., formely Immunol. Today 22 : 502-509 (2001)

2000
Freitas, A.A. & Rocha, B. (communiqué par Weill, J.-C.) Physiologie du système immunitaire: homéostasie des populations lymphocytaires. In : « La physiologie animale et humaine - vers une physiologie intégrative » Eds. Académie des Sciences 109-112 (2000)

Freitas, A.A. & Rocha, B. Population biology of lymphocytes: the flight for survival. Ann. Rev. Immunol. 18 : 83-111 (2000)

Agenes, F., Rosado, M.M. & Freitas, A.A. Peripheral B cell survival. Cell. Mol. Life Science 57 : 1220-1228 (2000)

Rosado, M.M. & Freitas, A.A. B cell positive selection by self antigens and counter-selection of dual B cell receptor in the peripheral B cell pools. Eur. J. Immunol. 30 : 2181-2190 (2000)

1999
Agenes, F. & Freitas, A.A. Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population. J. Exp. Med. 189 : 319-329 (1999)

Freitas, A.A. & Rocha, B. Peripheral T cell survival. Curr. Opin. Immunol. 11 : 152-156 (1999)

1998
Rosado, M.M. & Freitas, A.A. The role of the B cell receptor V region in peripheral B cell survival. Eur. J. Immunol. 28 : 2685-2693 (1998)

McLean A.R. Mathematical modelling of effectiveness. In: Preclinical and clinical development of new vaccines. Plotkin S., Brown F. & Horaud F. (eds). Dev. Biol. Stand. Basel, Karger. 95 : 225-233 (1998)

McLean A.R. Development and use of vaccines against evolving pathogens: vaccine design. In: Evolution in health and disease. S. Stearns (eds). Oxford University Press 138-151 (1998)

1997
McLean, A.R., Rosado, M.M., Agenes, F., Vasconcellos, R. & Freitas, A.A. Resource competition as a mechanism for B cell homeostasis. Proc. Natl. Acad. Sci. USA 94 : 5792-5797 (1997)

Tanchot, C., Lemonnier, F.A., Pérarnau, B., Freitas, A.A. & Rocha, B. Differential requirements for survival and proliferation of CD8 naïve or memory T cells. Science 276 : 2057-2062 (1997)

Freitas, A.A. & Rocha, B. Lymphocyte survival: a red queen hypothesis. Science 277 : 1950 (1997)

Feinberg, M.B. & McLean A.R. AIDS: decline and fall of immune surveillance? Curr. Biol. 7 : R136-R140 (1997)

Tanchot, C., Rosado, M.M., Agenes, F., Freitas, A.A. & Rocha, B. Lymphocyte homeostasis. Sem. in Immunol. 9 : 331-337 (1997)

1996
Jungmann, P., Freitas, A., Bandeira, A., Nobrega, A., Coutinho, A., Marcos, M.-A. & Minoprio, P. Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes. Scand. J. Immunol. 43 : 604-612 (1996)

Freitas, A.A., Agenes, F. & Coutinho, G.C. Cellular competition modulates survival and selection of CD8+ T cells. Eur. J. Immunol. 26 : 2640-2649 (1996)

1995
Chies, J.A.B., Marodon, G., Joret, A.-M., Regnault, A., Lembezat, M.-P, Rocha, B. & Freitas, A.A. Persistence of Vb6+ T cells in Mls-1amice. A role for the third complementarity-determining region (CDR3) of the T cell receptor b chain in superantigen recognition. J. Immunol. 155 : 4171-4178 (1995)

Rocha, B., Grandien, A. & Freitas, A.A. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181 : 993-1003 (1995)

Freitas, A.A., Rosado, M.M., Viale, A.-C. & Grandien, A. The role of cellular competition in B cell survival and selection of B cell repertoires. Eur. J. Immunol. 25 : 1729-1738 (1995)

Freitas, A.A. Lymphocytes in a model ecosystem. Res. Immunol. 146 : 225-233 (1995)

McLean, A.R. Vaccination, evolution and changes in the efficacy of vaccines: a theoretical framework. Proc. R. Soc. Lond. B. 261 : 389-393 (1995)

McLean, A.R. & Blower, S.M. Modelling HIV vaccination. Trends in Microbiol. 3 : 458-463 (1995)