Born the 22 DECEMBER 1947,
in CUAMBA, MOZAMBIQUE
NATIONALITY: PORTUGUESE
Education:
1970: M.D. University of Lisbon, Portugal
1972: General Internship in Internal Medicine. St. Mary’s Hospital, Lisbon. Portugal.
1976: Ph.D. in Immunology. University of Glasgow, U.K.
1982: “Agregé” in Immunology. New University of Lisbon, Portugal.
1971-1973: Internship at St. Mary’s Hospital, Lisbon. Portugal
1973-1976: Ph.D. student. Department of Immunology, Western Infirmary, Glasgow University.
1976-1977: Research Associate and Fellow. Memorial Sloan-Kettering Cancer Center, New York. USA.
1978-1978: Basel Institute for Immunology.
1977-1980: Auxiliary Professor. Department of Immunology. Faculty of Medical Sciences. New University of Lisbon, Portugal.
1980-1984: Associate Professor. Department of Immunology. Faculty of Medical Sciences. New University of Lisbon, Portugal.
1984- 2000: Chef de Laboratoire. Institut Pasteur à Paris. France.
1995-1999: Head of the "Laboratoire des Dynamiques Lymphocytaires". Institut Pasteur à Paris. France.
1997-2000: Head of the Department of Immunology. Institut Pasteur à Paris. France
1999- : Head of the "Unité Biologie des Populations Lymphocytaires". Institut Pasteur à Paris. France
2001- : Professor. Institut Pasteur à Paris. France.
2005- : Head of the CNRS URA 1961.
2006-2010 : Sub-Head of the Department of Immunology. Institut Pasteur à Paris. France
1979: Behring Prize of the Portuguese Society for Immunology.
1983: Pfizer Prize of the Society of Medical Science, Lisbon.
1988: Gulbenkian Prize for Science, Lisbon.
2011: Prize “Seeds of Science”, FCT, Lisbon
1 - Freitas, A A. (1972). Defices imunitarios. Rev. Port. Pediatria, 3:1,
2 - Lacerda, JMF, Mascarenhas, MJ & Freitas AA. (1973) Leucemia de monocitos. Jornal do Medico, 1562:77
3 - Freitas AA. (1973) Relacoes hospedeiro-tumor. Aspectos imunologicos das neoplasias. Medicina Universal, 16:323.
4 - Freitas AA & Machado Caetano, JA. (1973) Alfa-mercaptopropionilglicina e doenca de Wilson. Rev. Port. Terap. Med. 7:13.
5 - Freitas AA. (1973) Estudo de populaçoes linfocitarias humanas. I. Distribuicao relativa de linfocitos T e B no sangue periferico de uma populaçao normal. Jornal do Medico 1584:317.
6 - Freitas AA. (1973) Estudo de populacoes linfocitarias humanas. II. Distribuicao relativa de linfocitos T e B no sangue periferico de doencas linfoproliferativas. Jornal do Medico 1585:383
7 - Freitas AA, Forjaz de Lacerda, JM & Ducla Soares, A. (1973) Estudo de populacoes linfocitarias humanas. Distribuicao relativa de linfocitos T e B no sangue periferico do mieloma multiplo. Jornal do Medico 1587:506,
8 - Machado Caetano, JA, Silveira Nunes, MA, Mathioli, LJ, Mateus, AM, Freitas, AA, Pereira Luis, JH, Ricardo, JA, Clemente, AF & Gentil, F. (1974) Contribuicao para o estudo imunobiologico da doença neoplasica. Medicina Universal,17:10,137 & 198.
9 - Freitas AA & de Sousa, M. (1975) Control mechanisms of lymphocyte traffic. Modification of the traffic of 51Cr labelled mouse lymph node cells by treatment with plant lectins in intact and splenectomized hosts. Eur. J. Immunol., 5:831.
10 - Parrot, DMV, Rose, ML, Sless, F, Freitas, AA & Bruce, RG. (1976) Factors wich determine the accumulation of immunoblasts in gut and skin. Agents & Actions 6:32.
11 - Freitas AA & de Sousa, M. (1976) The role of cell interactions in the control of lymphocyte traffic. Cell. Immunol. 22:345.
12 - Freitas AA & de Sousa, M. (1976). Control mechanisms of lymphocyte traffic. Altered distribution of 51Cr labelled mouse lymph node cells pre-treated in vitro with lipolysaccharide. Eur. J. Immunol. 6:269.
13 - Freitas AA & de Sousa, M. (1976) Control mechanisms of lymphocyte traffic. Altered migration of 51Cr labelled mouse lymph node cells pre-treated in vitro with phospholipases. Eur. J. Immunol. 6:703.
14 - Freitas AA. (1976) Control mechanisms of lymphocyte traffic in mice. Ph.D. Thesis, Glasgow University.
15 - Freitas AA & de Sousa, M. (1977). Control mechanisms of lymphocyte traffic. A study of the action of two sulphated polysaccharides on the distribution of 51Cr- and 3H- labelled mouse lymph node cells. Cell. Immunol., 31:62.
16 - Freitas AA, Rose, ML & Parrot, DMV. (1977). Mesenteric and peripheral lymph node cells in the mouse: a common pool of small recirculating T lymphocytes. Nature, 270:731.
17 - Freitas AA, Rocha, B, Chiao,JW & de Sousa, M. (1978). Divergent actions of monomeric, dimeric and tetrameric Concanavalin A on lymphocyte traffic. Cell. Immunol., 35:59.
18 - De Sousa, M, Freitas, AA, Huber,B, Cantor,H, & Boyse, EA.(1979). Migratory patterns of the Ly subsetes of T lymphocytes in the mouse. In: "Function and structure of the immune system", Muller,W, Rucholtz & Muller, HK (Eds.). Hermelink Plenum Press, p. 51.
19 - Freitas AA & Bognacki, J. (1979). The role of cell locomotion in lymphocyte migration. Immunology, 36:247.
20 - Rocha, B, Freitas, AA & de Sousa, M. (1979). Characterization of rat spleen cell populations. I. cell interactions in the regulation of "in vitro" responses to Concanavalin A. Immunology, 36:619.
21 - Rocha, B, Cumano, A & Freitas, AA. (1979). Regulacao da resposta imunologica pelas celulas T no rato: mecanismos de interacçao celular. Acta Medica Portuguesa, 1:671.
22 - Freitas AA. (1980) Anatomia e fisiologia do sistema imune. Implicacoes e aplicacao pratica do controle da recirculacao linfocitaria. Boletim do Hosp. Geral de St. Antonio, II:121.
23 - Freitas AA & Rocha, B. (1980). Ontogenia e diferenciacao dos linfocitos B. Boletim do Hosp. Geral de St. Antonio, II:127.
24 - Freitas AA, Rose, ML & Rocha, B. (1980). Ramdom recirculation of small T lymphocytes from thoracic duct lymph in the mouse. Cell. Immunology, 56:29.
25 - Rocha, B, Freitas, AA & Parrot, DMV. (1980). Characterization of rat spleen cell populations. II. Activation by antigens and allogeneic cells. Immunology, 41:825.
26 - Freitas AA & Coutinho, AA. (1980). Characterization of mouse thoracic duct B-lymphocytes. I. Evidence for functional heterogeneity. Eur. J. Immunology, 10:772, 1980
27 - Freitas AA. (1981). Current concepts of lymphocyte- endothelium interactions. In: "The immune system", Lefkovits, I. & Steinberg, C. (Eds.) Vol. I, p 372.
28 - Freitas, AA & Coutinho, AA. (1981). Very rapid decay of mature B lymphocytes in the spleen. J. Exp. Med., 154:994.
29 - Freitas, AA, Rocha, B, Forni, L & Coutinho, AA. (1982). Population dynamics of B lymphocytes and their precursors: demonstration of high turnover in the central and peripheral lymphoid organs. J. Immunolgy, 128:54, 1982
30 - Rocha, B, Ferreira, AA, Munn, G, de Sousa, M & Freitas, AA. (1982). Spleen lymphocyte populations in patients with Hodgkin's disease. Properties of cells with diferent densities. Clin. Exp. Immunol., 48:300.
31 - Freitas AA, Rocha, B & Bognacki, J. (1983). Effects of intravenous administration of antigen on lymphocyte localization and blood flow into the mouse spleen. Acta Med. Port., 4:147.
32 - Valadas Preto, R, Rocha, B, Peixoto Menezes, A, Cruz, I. & Freitas, AA. (1983). Quadro morfologico de linfoma linfocitico associado a disfunçao T reversiveis, induzido pela difenil-hidantoina. J. do Medico, 2012:70.
33 - Coutinho,AA, Bandeira,A, Bjorklund,M, Forni,L, Forsgren,S, Freitas,AA, Gullberg,M, Holmberg,D, Ivars,I, Larsson,E-L, Leandersson,T, Martinez-A,C, Petersson,S & Probor,G. (1983). From the mechanisms of lymphocyte activation to the internal activity of the immune system. Ann. Immunol. (I.P.), 134:93.
34 - Rocha, B, Freitas,AA & Coutinho, AA. (1983). Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs .J. Immunolgy, 131:2158,.
35 - Rocha, B, Haston,W & Freitas,AA. (1984). Lymphocyte migration into collagen gels: role of lymph. Scand. J. Immunol. 19:297.
36 -Rocha, B, Larsson, E-L & Freitas, AA. (1984). Effects of hydroxyurea on Con-A induced T cell proliferation. Depletion of TCGF-reactive and TCGF producing T lymphocytes. Scand. J. Immunol. 19:315.
37 -Rocha, B & Freitas, AA. (1984). Subpopulacoes de linfocitos T no murganho: turnover maturaçao extratimica e capacidade de expansao pe-riferica. J. Ciencias Medicas, 7.
38 - Miranda, J L, Rocha, B & Freitas, AA. (1984). Lymphocyte migration into membrane filters: the role of lymph. Ann. Immunol. (I.P.), 135D:271.
39 - Coutinho,AA, Holmberg,D, Martinez-A,C, Freitas, AA, Larsson,E-L, Pereira,P & Bandeira,A (1985). Internal activity in the immune system and its physiological significance. Modern Trends in Human Leukemia. VI. In: "Haemotology and blood transfusion", v 29. Spinger Verlag, Berlin, p. 477.
40 - Rocha, B & Freitas, AA. (1985). O papel da linfa na migracao linfocitaria. Recirculacao mediada por efeitos quimiotacticos? J. Ciencias Medicas, 149:627.
41 - Cumano, AM, Vieira, P, Colle,J-H, Truffa-Bachi,P & Freitas, AA. (1986). Effects of Hydroxyurea "in vivo" treatment on the antibody response in the mouse. Ann. Immunol. (I.P.), 137D: 33.
42 - Freitas, AA, Rocha, B & Coutinho, AA. (1986). Life-span of B lymphocytes: the experimental basis for conflicting results. J. Immunol., 136:470.
43 - Freitas, AA, Rocha, B & Coutinho, AA. (1986). Two major classes of mitogen reactive B lymphocytes defined by life-span. J. Immunol., 136:466.
44 - Rocha, B & Freitas, AA. (1986). The effects of lymph on lymphocyte migration"in vivo". Ann. Immunol. (I.P.), 137D:105, 1986
44 - Rocha, B & Freitas, AA. (1986). The effects of lymph on lymphocyte migration"in vivo". Ann. Immunol. (I.P.), 137D:105, 1986
45 - Freitas, AA & Coutinho, AA. (1986). Population Kinetics of B lymphocytes. In: "Primary immunodeficiencies", Eibl, M & Rosen, FS, (Eds), Elsevier Publ. Co., Amsterdam, p 977.
46 - Portnoi,D, Freitas,AA, Holmberg,D, Bandeira,A & Coutinho,A. (1986). Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice. J. Exp. Med., 164:25.
47 - Freitas, AA, Rocha, B & Coutinho, AA. (1986). Lymphocyte population kinetics in the mouse. Immunol. Rev., 91:5.
48 - Pereira,P, Martinez-A,C, Bandeira,A, Freitas,AA & Coutinho, AA. (1986). Polyclonal B cell activation. Bull. Inst. Pasteur, 84:207.
49 - Freitas,AA, Guilbert,B, Holmberg,D, Wennerstrom,G, Coutinho,AA & Avrameas, S. (1986). Analysis of autoantibodies reactivities in hybridoma collections derived from normal adult BALB/c mice . Ann. Immunol. (I.P.), 137D:33.
50 - Holmberg,D, Freitas,AA, Portnoi,D, Jaquemart,F, Avrameas,S & Coutinho,AA. (1986). Antibody repertoires of normal BALB/c mice: B lymphocyte populations defined by state of activation. Immunol. Rev., 93:147.
51 - Novo, C, Fonseca, E & Freitas, AA.(1987). Altered fatty acid membrane composition modifies lymphocyte localization "in vivo". Cell. Immunol. 106:387,.
52 - Levy, M, Vieira, P, Coutinho, AA & Freitas, AA. (1987). The vast majority of natural immunoglobulin secreting cells are short-lived and the progeny of cycling lymphocytes. Eur. J. Immunol. 17:849.
53 - Rocha, B, Cumano, A, Vieira, P, Colle, J-H, Truffa-Bachi, P & Freitas, AA. (1988). Effects of surgical stress in lymphoid populations of mice In "Sirono Symposia Review", Stipa, Cavallaro and Zipano, Eds., vol. 1:221.
54 - Burlen, O, Coutinho, A & Freitas, AA. (1988). Long lasting thymus independent immune responses to anti-idiotype LPS conjugates requires continuous B cell renewal. Eur.J. Immunol. 18:1433.
55 - Freitas, AA, Burlen, O & Coutinho, A. (1988). Selection of antibody repertoires by anti-idiotype can occur at multiple steps of B cell diferentiation. J. Immunology. 140:4097.
56 - Colle, J-H, Truffa-Bachi, P & Freitas, AA. (1988). Secondary antibody responses to thymus independent antigens. Decline and life-span of memory. Eur. J. Immunol. 18:1307.
57 - Diguiero,G, Lim,A, Lembezat, M.P., Kaushik,A, Andrade,L, & Freitas, AA. (1988). Comparative study of Vh gene family usage by newborn Xid and non-Xid mice, new-born NZB and adult NZB mice and by splenic and peritoneal cavity B cellcompartments. Eur.J.Immunol. 18:1979.
58 - Freitas,AA, Pereira,P, Huetz,F, Thomas-Vaslin,V, Pena-Rossi,C, Andrade,L, Sundblad,A, Forni,L, & Coutinho,A. (1989). B cell activities in normal unmanipulated mice. In "B Lymphocytes: Function and regulation" Ed. P. del Guercio & J.M. Cruse. Contr. Microbiol. Immunol. 11: 1.
59 - Abraham,E, & Freitas,AA. (1989). Hemorrhage-induced alterations in immunoglobulin-secreting B cells. Crit. Care Med. 17:1015.
60 - Rocha,B, Lembezat,M.P., Freitas, AA & Bandeira,A. (1989). IL-2 receptor expression and IL-2 production in exponentially growing T cells: Major differences between "in vivo" and "in vitro" proliferating T lymphocytes.. Eur.J.Immunol. 19: 1137.
61 - Thomas-Vaslin,V & Freitas, AA. (1989). Lymphocyte population kinetics during the development of the immune system. B cell persistence and life-span can be determined by the host environment. Int. Immunol. 1: 237.
62 - Abraham,E & Freitas, AA. (1989). Hemorrage produces abnormalities in lymphocyte function and lymphokine generation. J.Immunol. 142:899.
63 - Abraham,E, Freitas, AA, & Coutinho,A. (1989). Hemorrage in mice produces alterations in B cell repertoires. Cell. Immunol. 122:208.
64 - Freitas, AA, Lembezat,M-P., & Coutinho,A. (1989). Expression of antibody V regions is genetically and developmentally controled and modulated by the lymphocyte environment. Int. Immunol. l:342,.
65 - Freitas, AA, Lembezat,M-P., & Rocha,B. (1989). Selection of antibody repertoires. Transfer of mature lymphocytes modifies VH gene family usage in the actual and available B cell repertoires of athymic mice. Int. Immunol. l:398.
66 - Andrade,L., Freitas, A.A., Huetz,F. & Coutinho, A. (1989). Immunoglobulin VH-gene expression in Ly1+ and conventional B cells. Eur. J. Immunol. 19: 1117.
67 - Poncet,P.,Reininger,L., Freitas,A.A., Holmberg,D., Dighiero,G. & Coutinho,A. (1989). Expression of VH11 genes family in hybridoma collections from peritoneum and spleen: differential correlation with BrMRBC reactivity. Res. Immunol. 140: 255.
68 - Holmberg, D. & Freitas, A.A. (1990). Establishment of V-gene repertoires in normal mice in "Molecular aspects of autoimmunity" Eds. N. Farid & C. Bona, p. 125, Academic Press, New York.
69 - Freitas, AA, Andrade, L., Lembezat, M-P., & Coutinho, A. (1990). Selection of VH gene repertoires: Differentiating B cells of adult bone marrow mimic fetal development. Int. Immunol. 2:15.
70 - Coutinho,A., Bandeira,A., Pereira,P., Portnoi,D., Holmberg,D., Martinez,C. & Freitas,A.A. (1990). Selection of antibody repertoires: the limits of clonal versus network organization. In "Cold Spring Harbor Symposium on Quantitative Biology" vol. 54, C.S.H.L. p. 159.
71 - Thomas-Vaslin, V. & Freitas, A.A. (1990). Population kinetics of peritoneal LPS-reactive B lymphocytes. Int. Immunol. 2:73.
72 - Mota-Santos,T.,Masmoudi,H.,Voegtle,D., Freitas,A.A., Coutinho,A. & Cazenave,P.-A. (1990). Divergency in the specificity of the induction and maintenance of neonatal supression. Eur. J. Immunol 20: 1717.
73 - Abraham,E., Freitas, A.A. & Coutinho, A.(1990). Purification and characterization of intraparenchymal lung lymphocytes. J. Immunol. 144:2117.
74 - Abraham, E., Andrade, L. & Freitas, A.A. (1990). Immunoglobulin VH-gene expression following hemorrage. Mol. Immunol. 27:921.
75 - Freitas, A.A., & Sidman, C. (1990). VH-gene families repertoires of "viable motheaten" (mev) mice. Eur. J. Immunol. 20: 1033.
76 - Abraham,E., Freitas,A.A., Jagels,M. & Chang, Y-H. (1990). T and CD8+ cells from hemorrhaged mice produce alterations in B cell repertoires. Immunobiology 181: 379.
77 - Rocha, B., Penit, C., Baron, C., Vasseur, F., Dautigny, N. & Freitas, A.A. (1990). Accumulation of BrdU labelled cells in central and peripheral lymphoid organs: minimal estimates of lymphocyte prodution and demonstration of high turnover rates for mature lymphocytes. Eur. J. Immunol. 20: 1697.
78 - Bos, N.A., Pleasants, J.R., Wostman, B.S., Freitas, A.A. & Benner, R. (1990). Renewal rate of B cells in germ-free Balb/c fed a chemically defined diet. Microecology and Therapy (Proc. Int. Symposium on Gnotobiology), 20: 191-196.
79 - Nardi, N., Freitas, A.A. & Coutinho, A. (1990). Frequency of anti-F protein B cells in normal, immunized and tolerant mice. Res. Immunol. 141:711.
80 - Grandien,A., Coutinho,A., Andersson,J. & Freitas, A.A. (1991). Endogenous VH-gene family expression in immunoglobulin-transgenic mice: Evidence for selection of antibody repertoires. Int. Immunol. 3:67.
81 - Freitas, A.A., Viale, A.-C.,Sundblad, A.,Heusser,C. & Coutinho, A. (1991). Normal serum immunoglobulinsparticipate in the selection of peripheral B-cell repertoires. Proc. Nat. Acad. Sci. (USA) 88:2640.
82 - Sundblad, A., Marcos, M.A.R., Huetz, F., Freitas, A.A., Heusser, C. Portnoi, D. & Coutinho, A. (1991). Normal serum immunoglobulins influence the numbers of bone marrow B and pre-B cells. Eur. J. Immunol. 21: 1155.
83 - Thomas-Vaslin, V., Andrade, L., Freitas, A.A. & Coutinho, A. (1991). Clonal persistence of B lymphocytes in normal mice is determined by V-region dependent selection. Eur. J. Immunol. 21:2239.
84 - d'Imperio Lima,M.R., Bandeira,A., Falanga,P., Freitas,A.A., Kipnis,T., Pereira da Silva,L. & Coutinho,A. (1991). Clonal analysis of lymphocyte responses in experimental malaria. I. Quantitation of B cell responses to P. Chabaudi infection of normal and immunoprotected animals. Int. Immunol. 3:1207.
85 - Grandien,A., Coutinho,A., Viale,A-C., Freitas, A.A., Andersson,J. & Marcos,M. (1992). On the origin of natural IgM in Ig-transgenic mice. Int. Immunol. 4:1153.
86 - Coutinho,A., Freitas,A.A., Holmberg,D. & Grandien,A. (1992). Expression and selection of murine antibody repertoires. Int. Rev. Immunol. 8:173.
87 - Viale,A-C., Coutinho,A. & Freitas,A.A. (1992). Differential expression of VH-gene families in peripheral B-cell repertoires of newborn or adult IgH congenic mice. J. Exp. Med. 175: 1449.
88 - Nagata,T.,Freitas,A.A. & Coutinho,A. (1992). VH-gene family repertoires in expressed and rearrenged VDJH gene amplified from murine spleen cells by PcR. Bul. Nippon Vet. Anim. Sci. Univ. 41:47.
89 - Haury,M., Freitas,A.A., Hermitte,V., Coutinho,A. & Hibner,U. (1993) The physiology of bcl-2 expression in murine B lymphocytes. Oncogene 8:1257.
90 - Freitas,A.A. & Rocha,B.B. (1993). Lymphocyte life-spans. Homeostasis, selection and competition. Immunology Today 14: 25.
91 Viale,A.-C., Coutinho,A., Heyman,R. & Freitas,A.A. (1993). V-region dependent selection of persistent resting peripheral B cells in normal mice. Int. Immunology 5: 599.
92 - Leijon,K., Freitas,A.A. & Holmberg,D. (1993). Analysis of VH gene utilization in the non-obese diabetic mouse. Autoimmunity 15:11.
93 - Freitas,A.A. & Rocha,B. (1994) Lymphocyte population kinetics. A cellular competition model. In "Autoimmunity. Physiology and disease." A. Coutinho & M. Kazatchkine (Eds.). John Wiley-Liss, New York p. 143-160.
94 - Chies,J.B., Viale,A.-C., Huetz,F., Weksler,M., Freitas,A.A. & Coutinho,A. (1994). VH-gene family dominance in aging mice. Scand. J. Immunol. 39:184.
95 - Viale,A.-C., Freitas,A.A. & Coutinho,A. (1994). Regulation of VH-gene expression is a lineage specific developmental marker. Eur. J. Immunol. 24:1353.
96 - Grandien,A., Modigliani,Y., Freitas,A.A., Anderson,J. & Coutinho,A. (1994). Positive and negative selection of antibody repertoires along B cell differentiation. Immunol. Rev. 137:53,.
97 - Sundblad, A., Marcos, M-A.R., Malenchere, E., Castro, A., Haury, M., Huetz, F., Nobrega, A., Freitas, A. & Coutinho, A. (1994). Observations on the mode of action of normal immunglobulin at high doses. Immunol. Rev. 139:125.
98 - Chies,J.B., Lembezat,M.P. & Freitas, A.A. (1994). Entry of B lymphocytes into the persistent cell pool in non-immunised mice is not accompanied by somatic mutation of VH-genes.Eur. J. Immunol. 24:1657.
99 - Rocha,B., Grandien,A. & Freitas, A.A. (1995). Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181:993.
100 - Freitas, A.A., Rosado, M.M., Viale, A.C. & Grandien, A. (1995). The role of cellular competition in B cell survival and selection of B cell repertoires. Eur. J. Immunol. 25:1729.
101 - Chies, J. A., Marodon, G., Joret, A-M., Regnault, A., Lembezat, M-P., Rocha, B. & Freitas, A.A. (1995). Persistence of Vb6+ T cells in Mls-1a mice: a role for the third complementary determining region (CDR3) of the TcR b chain in superantigen recognition. J. Immunol. 155:4171.
102 - Freitas, A.A. (1995). Lymphocytes in a model ecosystem. Res. Immunol. 146:225, 1995
103 - Jungman, P., Freitas, A., Bandeira, A., Minoprio, P. & Coutinho, A. (1996). Murine acariasis. II. Immunological disfunction and evidence for chronic activation of Th-2 lymphocytes. Scand. J. Immunol. 43:604.
104 - Freitas, A.A., Agenes, F. & Coutinho, G.C. (1996). Cellular competition modulates the survival and selection of CD8+ T cells. Eur. J. Immunol. 26:2640.
105 - Tanchot, C., Lemonnier, F.A., Perarnau, B., Freitas, A.A. & Rocha, B. (1997) Differential requirements for survival and expansion of CD8 naive or memory T cells. Science. 276:2057, 1997. see Comment in Science, 276:2000 .
106 - McLean, A., Rosado, M., Agenes, F., Vasconcelos, R. & Freitas, A.A. (1997) Resource competition as a mechanism for B cell homeostasis. Proc. Nat. Acad. Sci. (USA) 94:5792,1997 see Comment in Science, 276:1817.
107 - Agenes, F., Rosado, M.M. & Freitas, A.A. (1997) Independent homeostatic regulation of B cell compartments. Eur.J.Immunol. 27:1801 .
108 - Tanchot, C., Rosado, M.M., Agenes, F., Freitas, A.A. & Rocha, B. (1997) Lymphocyte homeostasis. Sem. Immunol.9 : 331-337 .
109 - Freitas, A.A. & Rocha, B. (1997) Lymphocyte survival: a Red Queen Hypothesis? (perspective) Science 277:1950 .
110 - Rosado, M.M. & Freitas, A.A. (1998) The role of B Cell Receptor V region in peripheral B cell survival. Eur. J. Immunol. 28 : 2685-2693.
111 - Agenes, F. & Freitas, A.A. (1999) Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population. J. Exp. Med. 189 : 319-329.
112 - Freitas, A.A. (1999) Populationsbiologie der B-Lymphozyten. Aspekte 11 : 20-28.
113 - Freitas, A.A. & Rocha, B. (1999) Peripheral T cell survival. Curr. Opin. Immunol. 11 : 152-156.
114 - Freitas, A.A. & Rocha, B. (2000) Population biology of lymphocytes : the flight for survival. Ann. Rev. Immunol. 18 : 83-111.
115 - Freitas, A.A. & Rocha, B. (2000) Physiologie du système immunitaire : homéostasie des populations lymphocytaires (communiqué par J.-C. Weil).In : Physiologie animale et humaines. Académie des Sciences, Tec & Doc. (eds), Paris p. 109-112.
116 - Agenes, F., Rosado, M.M. & Freitas, A.A. (2000) Peripheral B cell survival. Cell. & Mol. Life Sciences 57 : 1220-1228.
117 - Rosado, M.M. & Freitas, A.A. (2000) B cell positive selection by self antigens and counter-selection of dual B cell receptor cells in the peripheral B cell pool. Eur. J. Immunol. 30 : 2181-2190.
118 - Agenes, F., Rosado, M.M. & Freitas, A.A. (2000) Considerations on B cell homeostasis. Curr. Top. Microbiol. Immunol. 252 : 68-75.
119 - Li, F., Jin, F., Freitas, A.A., Szabo, P. & Weksler, M. (2001) Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur. J. Immunol. 31 : 500-505.
120 - De Boer, R., Freitas, A.A. & Perelson, A. (2001) Resource competition determines selection of B cell repertoires. J. Theor. Biol. 212:333-343.
121 - Almeida, A.R.M., Borghans, J.A.M. & Freitas, A.A. (2001) T cell homeostasis: Thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J. Exp. Med. 194 : 591-599.
122 - Legrand, N. & Freitas, A.A. (2001) CD8+ T lymphocytes in double ab TCR transgenic mice. I. TCR expression and thymus selection in the absence or in the presence of self-antigen. J. Immunol. 167 : 6150-6157.
123 - Legrand, N. & Freitas, A.A. (2001) CD8+ T lymphocytes in double ab TCR transgenic mice. II. Competitive fitness of dual ab TCR CD8+ T lymphocytes in the peripheral pools. J. Immunol. 167 : 6158-6164.
124 - De Boer, R.J., Freitas, A.A & Perelson, A.S. (2001) Resource competition determines selection of B cell repertoires. J. Theor. Biol. 212 : 333-343.
125 - Freitas, A. & Chen J. (2002) Introduction: regulation of lymphocyte homeostasis. Microbes & Infec. 4 : 529-530.
126 - Almeida, A.R.M., Legrand, N., Papiernick, M. & Freitas, A.A. (2002) Homeostasis of peripheral CD4+ T cells: IL-2Ra and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169 : 4850-4860.
127 - Gaudin, E., Hao, Y., Rosado, M.M., Chaby, R., Girard, R. & Freitas, A.A. Positive selection of B cells expressing low densities of self-reactive BCRs. J. Exp. Med. 199 : 843-853 (2004)
128 - Schlecht, G., Garcia, S., Escriou, N., Freitas, A.A., Leclerc C. & Dadaglio, G.
Murine plasmacytoid dendritic cells Cs induce effector/memory CD8+ T cells responses in vivo after viral stimulation
Blood 104 : 1808-1815 (2004)129 - Sanchez-Guajardo, V., Borghans, J.A.M., Marquez, M.-E., Garcia, S. & Freitas, A.A.
Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphopenia-driven proliferation.
J. Immunol. 174 : 1178-1187 (2005)130 - De La Coste, A., Six, E., Fazilleau, N., Mascarell L., Legrand, N., Mailhe, M.-P., Cumano, A., Laabi, Y. & Freitas, A.A.
In vivo and in absence of a thymus the enforced expression of the Notch ligands Delta-1 or Delta-4 promotes T cell development with specific unique effects.
J. Immunol. 174 : 2730-2737 (2005)131 - Almeida, A.R.M., Rocha, B., Freitas, A..A & Tanchot, C.
Homeostasis of T cell numbers : from thymus production to peripheral compartmentalization and the indexation of regulatory T cells
Sem. Immunol. 17 : 239-249 (2005)132 - Ghiringhelli, F., Ménard, C., Terme M., Flament, C., Taieb, J., Chaput, N., Puig, P.E., Novault, S., Escudier, B., Vivier, E., Lecesne, A., Robert, C., Blay, J.-Y., Caillat-Zucman, S., Freitas, A., Tursz, T., Wagner-Ballon, O., Capron, C., Vainchencker, W., Martin, F. & Zitvogel, L.
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-b-dependent manner.
J. Exp. Med. 202 : 1075-1085 (2005)133 - Marquez M.-E., Ellmeier W., Sanchez-Guajardo V., Freitas A.A., Acuto O. & Di Bartolo V.
T cell sensory adaptation dependent on TCR avidity for self-antigens.
J. Immunol. 175 : 7388-7397 (2005).134 - Wildin, R.S. & Freitas, A.
IPEX and Foxp3 : clinical and research perspectives
J. Autoimmunity 25 : 56-62 (2005)135 - De la Coste, A. & Freitas, A.A.
Notch signaling : distinct ligands induce specific signals during lymphocyte development and maturation
Immunol letters 102 : 1-9 (2006)136 - Almeida ARM, Zaragoza B. & Freitas AA.
Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2 producing cells.
J. Immunol. 177 : 192-200 (2006)137 - Hao Y., Legrand L. & Freitas AA.
The clone size of peripheral CD8 T cells is regulated by TCR promiscuity
J. Exp. Med. 203 : 1643-1649 (2006)138 - Almeida, ARM., Zaragoza, B. & Freitas A.A.
Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells
Int. Immunol 18 : 1607-1613 (2006)139 - Sanchez-Guajardo, V., Tanchot, C., O’Malley, J.T., Kaplan, M.H., Garcia, S. & Freitas, A.A.
Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6
J. Immunol. 178 : 7550-7556 (2007)
140 - Lampropoulou, V., Hoehlig, K., Roch, T., Neves, P., Calderon Gomez, E., Sweenie, C.H., Hao, Y., Freitas, A.A., Steinhoff, U., Anderton, S.M. & Fillatreau, S.
TLR- activated B cells suppress T cell-mediated autoimmunity.
J. Immunol. 180 : 4763-4773 (2008)
141 - Thiriot, A., Freitas, A.A. & Rueff-Juy D.
Peritoneal B-cell subsets in the genus Mus : their role in innate immunity
Crit Rev Immunol. 28 : 341-361 (2008)142 - Thiriot Aude, Drapier Anne-Marie, Mémet Sylvie, Fitting Catherine, Sturny-Leclere Aude, Cavaillon Jean-Marc, Cazenave Pierre-André, Freitas Antonio A. & Rueff-Juy Dominique
Wild-derived mouse strains, a valuable model to study B cell responses
Mol. Immunol., 46 : 601-612 (2009)143 - Freitas, A.A. & Rocha B.
Homeostasis of naive T cells : the Foxo that fixes.
Nature Immunol. 10 : 133-144 (2009)144 - Leitao, C., Freitas, A.A. & Garcia, S.
The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool.
J Immunol. 182 : 5232-5239 (2009)145 - de Freitas A.A.
Tractus Immuno-Logicus. A brief History of the Immune System
Eds Landes Bioscience (2009)146 - Montaudouin, C., Boucontet, L., Mailhe-Lembezat, M.-P., Mariotti-Ferrandiz, M.-E., Louise, A., Six, A., Freitas, A.A. & Garcia, S.
Endogenous TCR recombination in TCR Tg single Rag-deficient mice uncovered by robust in vivo T cell activation and selection.
PLoS ONE 5 : e10238 (2010)147 - Lalanne A.I., Moraga I., Hao Y., Pereira J.P., Alves N.L., Huntington N.D., Freitas A.A., Cumano A. & Vieira P.
CpG inhibits Pro-B cell expansion through a cathepsin B-dependent mechanism.
J. Immunol. 184 : 5678-5685 (2010)148 - Zaragoza, B., Evaristo, C., Kissenpfennig, A., Libri, V., Malissen, B., Rocha, B., Freitas, A.A. & Almeida, A.R.M.
Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8+ TCM and TEM cell pools.
PLoS ONE 6 : e17423 (2011)149 - Almeida, A.R.M., Amado, I.F., Reynolds, J., Berges, J., Lythe, G., Molina-Paris, C. & Freitas, A.A.
Quorum-sensing in CD4+ T cell homeostasis : a hypothesis and a model.
Frontiers in Immunol. 3, article 125 : 1-15 (2012)150 - Garcia, S. &. Freitas A.A.
Humanized mice : current states and perspectives
Immunol. Letters, 146 : 1-7 (2012)151 - Montaudouin, C., Anson, M., Hao, Y., Duncker, S.V., Fernandez, T., Gaudin, E., Ehrenstein, M., Kerr, W.G., Colle, J.-H., Bruhns, P., Daëron, M. & Freitas, A.A.
Quorum sensing contributes to activated IgM-secreting B cell homeostasis.
J. Immunol. 190 : 106-114 (2013)
