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Institution
The UPRES EA 2128 belongs to the University of
Caen France, and is a Collaborative Research Unit dedicated to the
study of infectious diseases. Researchers from various laboratories
form the scientific team, in particular researchers from the Laboratory
of Human and Molecular Virology (Pr F. Freymuth). It brings together
three fields of activity, namely research, education and public
health. “Human respiratory viral infections” is one
prominent research topic of this UPRES.
Participants
The Laboratory of Human and Molecular Virology,
located at the University Hospital of Caen, is led by Prof François
Freymuth. He was trained as a medical doctor in France, got most
if his experience in virology in Manchester (Prof Longson) and became
Professor of Bacteriology, Virology, Hygiene in 1976. He is a specialist
in the field of respiratory viral infections, and an expert in the
qualification and control of virological reagents at the AFSSAPS,
the French Drug Agency. He is interested in clinical virology and
epidemiology, as well as in basic virology. Respiratory syncytial
virus, human metapneumovirus and human coronavirus infections are
leading fields of research for this laboratory. Dr Astrid Vabret
is the senior researcher of the team specialized in coronavirus
infections in humans, and works on 229E and OC43 coronaviruses.
The laboratory maintains a collection of referent
coronaviruses strains.
Participation of women : Astrid Vabret, one of the senior
researchers.
Roles in the project
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Expertise in medical virology (evaluation
of the quality of serological tests and rapid diagnostic tests)
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Expertise in other known coronaviruses in
humans and animals (viral culture and molecular diagnosis) and
comparative virology
Publications
5 recent publications
1. Pene F, Merlat A, Vabret A, …. Freymuth F. Coronaviruse
229E-related pneumonia in immunocompromised patients. Clin Infect
Dis 2003;37:929-32.
2. Vabret A., Mourez T., Gouarin S., Petitjean
J., and Freymuh F. An outbreak of coronavirus OC43 respiratory infection
in Normandy, France. Clin. Infect. Dis., 2003 ; 36 : 985-989.
3. Freymuth F., Vabret A., Legrand L., Eterradossy
N., Lafay-Delaire F., Brouard J., Guillois B. Presence of the new
human metapneumovirus in French children with bronchiolitis. Pediatr.
Infect. Dis. 2003; 22 (1) : 92-94.
4. Gueudin M., Vabret A., Petitjean J., Gouarin
S., Brouard J., and Freymuth F. Quantification of respiratory syncytial
virus RNA in nasal aspirates of children by real-time RT-PCR assay.
J. Virol. Methods, 2003; 109 (1) :39-45.
5. Vabret A., Mouthon F., Mourez T., Gouarin S.,
Petitjean J., and Freymuth F. Direct diagnosis of human respiratory
coronaviruses 229E and OC43 by the polymerase chain reaction. J.
Virol. Methods, 2001; 97 : 56-66.
6. Freymuth F., Vabret A., Brouard J., Toutain
F., Verdon R., Petitjean J., Gouarin S., Duhamel JF, Guillois B.
Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae
infections in exacerbations of asthma in children. J. Clin. Virol.,
1999; 13 : 131-139.
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