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Institution
The Chinese National Human Genome Center at Shanghai
(CHGCS) was established in Zhang-Jiang Hi-Tech Park, Pudong, Shanghai
on October 29th, 1998. It is supported by the National Ministry
of Science and Technology and several local institutions. The Research
Department is doing (1) Genomic sequencing (mainly carrying out
human genome sequencing, pathogenic microbe genome sequencing and
EST sequencing), (2) Disease genomics (study on the chain analysis
of disease related genes, gene localization, genome scanning and
the study of human diversity), (3) Functional genomics (carrying
out full-length cDNA cloning and gene function research using cDNA
array and yeast two-hybrid system etc. ) and (4) Bioinformatics
(provide bioinformatics support to the research of the other three
departments; database development and maintaining; bioinformatics
program developing).
The research resource includes a Sample Collection Network (nationwide
network for collection and preservation of genetic materials), a
Large-scale Sequencing Platform (comprehensive genomic research
technology system), and a Disease-related Genomics Platform.
Participants
Prof ZHAO GuoPing is the executive director of
the CHGCS, and has been early on involved in SARS research. The
Disease-related Genomics Platform has already sequenced several
SARS CoV and SARS-like CoV strains and has built a bioinformatics
analysis database of SARS virus genome (www.chgc.org.cn/bioinformatics).
Roles in the project
Publications
5 recent publications:
1. Yu H, Yang Y, Zhang W, Xie YH, Qin J, Wang Y, Zheng HB, Zhao
GP, Yang S, Jiang WH. Expression and purification of recombinant
SARS coronavirus spike protein
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Aug;35(8):774-8.
Chinese.
2. Qin L, Xiong B, Luo C, Guo ZM, Hao P, Su J,
Nan P, Feng Y, Shi YX, Yu XJ,
Luo XM, Chen KX, Shen X, Shen JH, Zou JP, Zhao GP, Shi TL, He WZ,
Zhong Y, Jiang
HL, Li YX. Identification of probable genomic packaging signal sequence
from SARS-CoV genome by bioinformatics analysis. Acta Pharmacol
Sin. 2003 Jun;24(6):489-96.
3. Yu XJ, Luo C, Lin JC, Hao P, He YY, Guo ZM,
Qin L, Su J, Liu BS, Huang Y,
Nan P, Li CS, Xiong B, Luo XM, Zhao GP, Pei G, Chen KX, Shen X,
Shen JH, Zou JP, He WZ, Shi TL, Zhong Y, Jiang HL, Li YX. Putative
hAPN receptor binding sites in SARS-CoV spike protein.
Acta Pharmacol Sin. 2003 Jun;24(6):481-8.
4. Chen RS, Shen Y, Chen Z, Yuan ZH, Zhao GP, Qu
D, Danchin A, Wen YM. Genome-based analysis of virulence genes in
a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228).
Mol Microbiol.
2003 Sep;49(6):1577-1593.
5. Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu
H, Zhang YX, Xiong H, Lu G, Lu
LF, Jiang HQ, Jia J, Tu YF, Jiang JX, Gu WY, Zhang YQ, Cai Z, Sheng
HH, Yin HF,
Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, Ma W, Yao ZJ,
Shen Y, Qiang
BQ, Xia QC, Guo XK, Danchin A, Saint Girons I, Somerville RL, Wen
YM, Shi MH,
Chen Z, Xu JG, Zhao GP. Unique physiological and pathogenic features
of Leptospira interrogans revealed by
whole-genome sequencing. Nature. 2003 Apr 24;422(6934):888-93.
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