The Spirochaete Groups at the Institute Pasteur

Unité de Bactériologie Moléculaire et Médicale,
Institut Pasteur,
28 rue du Dr Roux,
75724 Paris cedex 15,
FRANCE.
telephone +33 1 45 68 83 37 (secretariat) +33 1 45 68 80 00 (switchboard)
fax + 33 1 40 61 30 01

Publications 1990-1997

Research Interests

Spirochaetes are zoonosis agents which can affect man. Leptospirosis is an acute illness which can cause death while Lyme borreliosis is a chronic disease, the etiologic agent of which was recently discovered (1982). Our main interests were Leptospira interrogans and Borrelia burgdorferi, but now includes Serpulina, an agent of swine dysentery which can also colonize the human intestinal tract, and Treponema denticola, one of the agents of periodontal diseases. The main results obtained are the following:
1) The delineation of three pathogenic species of B. burgdorferi sensu lato, agent of Lyme borreliosis and identification of 7 other species and several further genomospecies.
2) Spirochaete genome structure. Genetic and physical maps of the linear chromosomes of the three new species of B. burgdorferi. (Evidence for a linear chromosome was presented in 1990). Evidence for two circular chromosomes for Leptospira interrogans and for a circular chromosome and a cryptic plasmid for Treponema denticola .
3) Identification of Leptospira interrogans by ribotyping, Arbitrarily Primed PCR and pulsed field gel electrophoresis.
The "Unité de Bactériologie Moléculaire et Médicale" includes a National Reference Centre and WHO Collaborative Centre for Leptospira. The presence of these centres implies applied research including for example, improvement of diagnostic methods by ELISA and PCR, and identification by pulsed field gel electrophoresis.


Leptospires & Lyme Group

Group Leader

Professor Guy Baranton gbaran@pasteur.fr +33 (0)1 45 68 80 00 ext 72 32
Head of the Molecular and Medical Bacteriology Unit

Permanent Scientific Staff

Dr Danièle Postic dpostic@pasteur.fr +33 (0)1 45 68 83 67

Temporary Scientific Staff

Ms Nuria Marti Ras nmarti@pasteur.fr +33 (0)1 45 68 80 00 ext 72 08

Technical Staff

Ms Pascale Amouriaux-Bourhy pbourhy@pasteur.fr +33 (0)1 45 68 80 00 ext 72 08

Ms Elisabeth Bellenger ebellen@pasteur.fr+33 (0)1 45 68 80 00 ext 72 34

Ms Edith Fournie-Amazouz serpu@pasteur.fr+33 (0)1 45 68 80 00 ext 79 42

Ms Natacha Sertour nsertour@pasteur.fr+33 (0)1 45 68 80 00 ext 72 34


Molecular Genetics of Spirochetes Group

Group Leader

Dr Isabelle Saint Girons isgirons@pasteur.fr +33 (0)1 45 68 83 66
Head of the Bacteriology and Mycology Department

Permanent Scientific Staff

Dr Catherine Werts cwerts@pasteur.fr +33 (0)1 45 68 83 68
(On Leave)

Temporary Scientific Staff

Ms Audrey Brenot abrenot@pasteur.fr +33 (0)1 45 68 80 00 ext 72 33

Technical Staff

Ms Catherine Ottone cotton@pasteur.fr +33 (0)1 45 68 80 00 ext 72 33


Secretarial Staff

Ms Annie Duvaquier spiroc@pasteur.fr +33 (0)1 45 68 83 37

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