Borrelia burgdorferi Gene-Protein index

DNABorrelia burgdorferi, B. garinii and B. afzelii genes grouped by functionProtein

These data are an update of those reviewed by:
Baranton,G. & Old,I.G. (1995) The Spirochaetes: a different way of life. Bull. Inst. Pasteur. 93: 63-95

The tables are based on the E. coli index:
#Riley,M. (1993) Functions of the gene products of Escherichia coli. Microbiol. Rev. 57: 862-952.

The annotations are in the following format:

  • Gene Gene Product (Enzyme number) References (if no sequence in bank)
    B. burgdorferi 212 Map Location (kbp) Link to Sequence (if available)
    B. garinii 20047 Map Location (kbp) Link to Sequence (if available)
    B. afzelii VS461 Map Location (kbp) Link to Sequence (if available)

    Distribution of cellular functions of E. coli and B. burgdorferi genes

    E. coli genes*
    #
    E. coli genes*
    %
    Category B. burgdorferi genes
    #
    B. burgdorferi genes
    %
    37522% I Intermediary metabolism 8 4.9%
    31919% II Biosynthesis of small molecules53.1%
    41925% III Macromolecule metabolism3622.2%
    1418% IV Cell Structure 6037.0%
    30418% V Cellular processes12 7.4%
    1448% VI Other functions 95.6%
    00% VII Unknown functions 32 19.8%


    Legend

    nd not determined; c chromosome; lp linear plasmid; cp circular plasmid

    Synonyms

    bmpA = tmbC = p39
    dnaK = hsp70
    flaB = fla = p41
    ftsQ = divIB
    gap = G3PDH
    groEL = hsp60
    hip = himD
    pep = APEI
    p60 = "PCR"
    sod = sodA = sodM

    Many chromosomal genes were mapped in B. burgdorferi strain 212, B. garinii strain 20047 and B. afzelii strain VS461.

    1. Davidson, B. E., J. MacDougall and I. Saint Girons. 1992.
      Physical map of the linear chromosome of the bacterium Borrelia burgdorferi 212, a causative agent of Lyme disease, and localization of rRNA genes.
      J. Bacteriol. 174: 3766-3774.

    2. Old, I. G., J. Macdougall, I. Saint Girons and B. E. Davidson. 1992.
      Mapping of genes on the linear chromosome of the bacterium Borrelia burgdorferi - possible locations for its origin of replication.
      FEMS Microbiol Lett. 99: 245-250.

    3. Ojaimi, C., B. E. Davidson, I. Saint Girons and I. G. Old. 1994.
      Conservation of gene arrangement and an unusual organization of rRNA genes in the linear chromosomes of the Lyme disease spirochaetes Borrelia burgdorferi, B. garinii and B. afzelii.
      Microbiol. 140: 2931-2940.

    Additionally, hip & recA, were mapped in B. burgdorferi (Sh-2-82) while p22A, parC, priA and LA7 were mapped for several Borrelia species
    1. Casjens, S. and W. M. Huang. 1993.
      Linear chromosomal physical and genetic map of Borrelia burgdorferi, the Lyme disease agent.
      Mol. Microbiol. 8: 967-980.

    2. Casjens, S., M. Delange, H. L. Ley, P. Rosa and W. M. Huang. 1995.
      Linear chromosomes of Lyme disease agent spirochetes: genetic diversity and conservation of gene order.
      J Bacteriol. 177: 2769-2780.

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