Résumé de : GONZALEZ (JP), CORNET (JP), WILSON (ML) & CAMICAS (JL) - 1991 - Crimean-Congo Haemorrhagic Fever Virus Replication in Adult Hyalomma truncatum and Amblyomma variegatum Ticks. Research in Virology 142: 6 (NOV-DEC 1991), pp. 483-488.


The kinetics of the replication of the Crimean-Congo haemorrhagic fever virus (CCHFV) was studied in intra-anally inoculated adult Hyalomma truncatum and Amblyomma variegatum ticks. The virus was re-isolated by suckling mouse inoculation and revealed by antigen capture with ground ticks and indirect immunofluorescence of haemolymph. The virus was detected in ticks in the first hours post-inoculation (p.i.) and its replication was observed from 36 h p.i. onwards. Virus titre reached a maximum within 3-5 days then decreased slowly to a level of at 2 log LD50/ml for several months until the end of observations. Several specific, non-identified factors seem to favour CCHFV replication in H. truncatum. Long-term virus persistence seems to occur in CCHFV-infected adult ticks.