Epidemiology of Emerging Diseases  


  HEADFONTANET Arnaud / fontanet@pasteur.fr
  MEMBERSMr BECHET Stéphane, Mme BONNEFOY Géraldine, Dr BREBAN Romulus, Mr CHARTIER Loïc, Dr DELAROCQUE-ASTAGNEAU Elisabeth, Dr GARENNE Michel, Dr GILES-VERNICK Tamara, Ms LECLERC Pauline, Ms LEFOULER Lenaïg, Dr MADEC Yoann, Ms PAEZ Adela, Dr REY-CUILLE Marie-Anne, Ms TAYLOR Sylvia, Mrs THEPAUT Sylvana, Mrs VRAY Muriel


  Annual Report

The Emerging Diseases Epidemiology Unit was founded on July 1st, 2001. Its mandate was to develop its own research agenda in the field of infectious diseases epidemiology, and to provide expertise in epidemiology and biostatistics to other laboratories.

Based on the potential for collaborations with the international network of Institut Pasteur, and on our past experience in international health, we decided to focus on theepidemiology of infectious and tropical diseases in resource-limited countries.

Each researcher has its own field of expertise: Arnaud Fontanet in analytical epidemiology (cohort and case-control studies), Muriel Vray in the methodology of clinical trials, Michel Garenne in demography and Romulus Breban in mathematical modeling.

All projects deal with the epidemiology of viral diseases in resource-limited countries. One common research area isHIV/AIDS. Other research areas includehepatitis Cin Egypt, hepatitis B in Senegal,acute encephalitis in Vietnam, and dengue in Asia and Latin America (see website and Figure). Emphasis has been put in clinical research, i.e., cohort studies and clinical trials on subjects infected with a pathogen. In addition, four staff members, Yoann Madec, Loïc Chartier, Lénaïg Lefouler and Stéphane Béchet provide transversal support to all projects of the unit in biostatistics and data management.

We also offer expertise in the area of epidemiology and biostatistics to other research units of the institute and organize epidemiology and biostatistics courses. In this context, special effort has been dedicated to the preparation of epidemiology and biostatistics curricula for the new Pasteur/CNAM School of Public Health (see website below).

Keywords: epidemiology, clinical research, mathematical modeling, HIV, viral hepatitis, emerging viruses

Epimal.jpg

Weiss RA, Nature Medicine, 2004



  Publications

Vray M, Germani Y, Chan S, Duc NH, Sar B, Sarr FD, Bercion R, Rahalison L, Maynard M, L’Her P, Chartier L, Mayaud C. Clinical features and etiology of pneumonia in acid-fast bacillus sputum smear-negative HIV-infected patients hospitalized in Asia and Africa. AIDS. 2008;22:1323-32.

Tollman SM, Kahn K, Sartorius B, Collinson MA, Clark SJ, Garenne M. Implications of mortality transition for primary health care in rural South Africa: a population-based surveillance study.
Lancet. 2008;372:893-901

Plancoulaine S, Mohamed MK, Arafa N, Bakr I, Rekacewicz C, Trégouët DA, Obach D, El Daly M, Thiers V, Féray C, Abdel-Hamid M, Abel L, Fontanet A Dissection of familial correlations in hepatitis C virus (HCV) seroprevalence suggests intrafamilial viral transmission and genetic predisposition to infection. Gut. 2008;57:1268-74

Abdoul H, Mallet V, Pol S, Fontanet A. Serum alpha-fetoprotein predicts treatment outcome in chronic hepatitis C patients regardless of HCV genotype. PLoS ONE. 2008;3:e2391

Le Minor O, Germani Y, Chartier L, Lan NH, Lan NT, Duc NH, Laureillard D, Fontanet A, Sar B, Saman M, Chan S, L’Her P, Mayaud C, Vray M. Predictors of pneumocystosis or tuberculosis in HIV-infected Asian patients with AFB smear-negative sputum pneumonia. J Acquir Immune Defic Syndr. 2008 Aug 15;48:620-7.



  Web Site

More informations on our web site




Activity Reports 2009 - Institut Pasteur
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