HEADDr Elisabeth Carniel /
  MEMBERSDr Chauvaux Sylvie, Dr Chouikha Iman, Delarue Nadine, Dr Demeure Christian
Dr Derbise Anne, Fayolle Corinne, Fisher Aurélie, Dr Ferreira Anthony, Goulard Céline
Dr Guinet Françoise, Huon Christèle, Dr Jacob Sandrine, Langrand Sophie, Leclercq Alexandre, Martin Liliane

  Annual Report

The YersiniaResearch Unit was created in 2004. This Unit focuses its research activities on the genus Yersinia, which belongs to the family Enterobacteriaceaeand includes three species pathogenic for humans and animals: the enteropathogens Y. pseudotuberculosisand Y. enterocolitica, and the plague agent Y. pestis.

The current activities of the YersiniaResearch Unit are primarily devoted to the analysis of:

- The mechanisms of genetic transfer in Yersinia.

- Comparative genomics and transcriptomics between Y. pestisand Y. pseudotuberculosis.

- The molecular bases for the exceptional pathogenicity of Y. pestisafter its recent emergence from Y. pseudotuberculosis.

- The pathophysiology of Yersinia infection.

- The host's mechanisms of innate and acquired immunity.

- The development of a vaccine against plague and pseudotuberculosis.

- The genetic bases of susceptibility to plague.

- The resistance of pathogenic Yersiniato antibiotics.

- The evolution of pathogenic Yersinia.

- The development of typing tools for molecular epidemiology.

- Public health (French Reference Laboratory, National Surveillance Network, and WHO Collaborating Center for Yersinia).

Keywords: Yersinia, plague, pathogenesis, genomics, transcriptomics, pathophysiology, vaccine, immunity, public health, evolution, molecular epidemiology, antibiotic, genetic transfer, phage


- P. Chain, E. Carniel, F. Larimer, J. Lamerdin, P. O. Stoutland, W. M Regala, A. M. Georgescu, L. M. Vergez, M. Land, L. V. Motin, R. R. Brubaker, J. Fowler, J. Hinnebusch, M. Marceau, C. Medigue, M. Simonet, V. Chenal-Francisque, B. Souza, D. Dacheux, J.M. Elliott, A. Derbise, L. Hauser, and E. Garcia. 2004. Insights into the genome evolution of Yersinia pestisthrough whole genome comparison with Yersinia pseudotuberculosis. Proc. Natl. Acad. Sci. USA. 101:13826-13831.

- M. Achtman, G. Morelli, P. Zhu, T. Wirth, I. Diehl, D. Wagner,C. Allender, R. Easterday, V. Chenal-Francisque, P. Worsham, N. R. Thomson, J. Parkhill, L. E. Lindler, E. Carniel and P. Keim. 2004. Microevolution and history of the plague bacillus, Yersinia pestis. Proc. Natl. Acad. Sci. USA. 101:17837-17842.

- M. Eppinger, M.J. Rosovitz, W.W. Fricke, D.A. Rasko, G. Kokorina, C. Fayolle, L.E. Lindler, E. Carniel, J. Ravel. 2007. Genome Sequence of Y. pseudotuberculosisIP31758, the causative agent of Far East Scarlet Like Fever: Linking Genomic Plasticity to Pathogenicity. PLoS Genetics. 3:e142.

- A. Derbise, V. Chenal-Francisque, F. Pouillot, C. Fayolle, M-C. Prévost, C. Médigue, B. J. Hinnebusch and E. Carniel. 2007. An horizontally acquired filamentous phage contributes to the pathogenicity of the plague bacillus. Mol. Microbiol. 63:1145-1157.

- Welch, T. J., W. F. Fricke, P. F. McDermott, D. G. White, M.-L. Rosso, D. A. Rasko, M. K. Mammel, M. Eppinger, M. J. Rosovitz, D. Wagner, L. Rahalison, J. E. LeClerc, J. M. Hinshaw, L. E. Lindler, T. A. Cebula, E. Carniel, and J. Ravel. 2007. Multiple antimicrobial resistance in plague: an emerging public health risk. PLoS One. 2:e309.

Activity Reports 2007 - Institut Pasteur
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