The Genomics platform carries out collaborative projects with different teams from the Institut Pasteur which is partly funded by the National Genopoles Network (http://rng.cnrg.fr). These large scale genomics projects are carried out using semi-automated techniques. Although the majority of projects concern the complete genomic sequencing of microorganisms or a low coverage genomic sequence, the platform also carries out sequencing of ESTs (Expressed Sequence Tags) and molecular typing of bacterial strains.

Projects realized in 2007 and current projects

• Allelic diversity of Plasmodium vivax isolates from Madagascar to study diversity and the drug resistance

Didier Ménard – Unité de Recherche sur le Paludisme – Institut Pasteur de Madagascar

• Sequencing of a cDNA library from Anopheles gambiae (sexual tractus of male mosquito)

Karin Eiglmeier – Unité de Biochimie et de biologie moléculaire des insectes

• Sequencing of a cDNA library from Entamoeba histolytica

Nancy Guillen – Unité de Biologie cellulaire du parasitisme

• Organization of theIgH locus in the alpaga ( Lama pacos)

Pierre Lafaye – Unité de Génétique et biochimie du développement

• Molecular typing of CIP Bacteria strains

Chantal Bizet – Collection de l'Institut Pasteur

• Sequencing of two multi-drug resistant plasmids in Yersinia pseudotuberculosis

Elisabeth Carniel – Unité Yersinia

• Genome sequencing of Helicobacter pylori (MALT lymphoma associated strain)

Agnés Labigne – Unité de Pathogénie bactérienne des muqueuses

• Genome sequencing of a Streptococcus pneumoniae strain (serotype 1)

Frank Kunst – Unité de Génomique des micro-organismes pathogènes

• Genome sequencing of a Streptococcus macedonicus strain (CIP105685T)

Patrick Trieu-Cuot – Unité de Biologie des bactéries pathogènes à Gram-positif

Stinear TP, Seemann T, Pidot S, Frigui W, Reysset G, Garnier T, Meurice G, Simon D, Bouchier C, Ma L, Tichit M, Porter JL, Ryan J, Johnson PD, Davies JK, Jenkin GA, Small PL, Jones LM, Tekaia F, Laval F, Daffé M, Parkhill J, Cole ST. Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res. 2007 Feb;17(2):192-200.

Noranate N, Durand R, Tall A, Marrama L, Spiegel A, Sokhna C, Pradines B, Cojean S, Guillotte M, Bischoff E, Ekala MT, Bouchier C, Fandeur T, Ariey F, Patarapotikul J, Le Bras J, Trape JF, Rogier C, Mercereau Puijalon O. Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use. PLoS ONE. 2007 Jan 3;2(1):e139.

Bougnoux ME, Pujol C, Diogo D, Bouchier C, Soll DR, d'Enfert C. Mating is rare within as well as between clades of the human pathogen Candida albicans. Fungal Genet Biol. 2007 Oct 23.

Weber C, Guigon G, Bouchier C, Frangeul L, Moreira S, Sismeiro O, Gouyette C, Mirelman D, Coppee JY, Guillon N. Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GalNAc lectin in Entamoeba histolytica. Eukaryot Cell. 2006 May;5(5):871-5.

Cazalet C, Rusniok C, Brüggemann H, Zidane N, Magnier A, Ma L, Tichit M, Jarraud S, Bouchier C, Vandenesch F, Kunst F, Etienne J, Glaser P, Buchrieser C. Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nat Genet. 2004 Nov;36(11):1165-73.