|HEAD||PREVOST, Marie-Christine / firstname.lastname@example.org|
|MEMBERS||Dr. BONNE, Isabelle / CAYET, Nadège / GUADAGNINI, Stéphanie / Dr. LOUSSERT, Céline
MALLET, Adeline / PEHAU-ARNAUDET, Gérard / Dr. SACHSE, Martin / SCHMITT, Christine / VILEY, Christine
The work in the platform for ultrastructural microscopy (PFMU) consists of high resolution ultrastructural analysis aimed at answering scientific questions in collaboration with departments of the Pasteur Institute and with other research establishments such as: INSERM, CNRS, laboratories from different Universities, Curie Institute, Necker Hospital, National Center of Reference and the International network of Pasteur Institutes.
Within these projects, new approaches and technologies are implemented or developed to obtain the best performances when answering to specific questions.
The morphological expertise of the platform lies in the following areas:
In addition, the PFMU offers service activities for rapid diagnosis of agents responsible for new emerging diseases.
Within the institute, the PFMU offers training sessions for users to become autonomous in sample preparation as well as in the samples analysis.
Outside the institute, the PFMU participates in the organization of workshops for a wider audience as the CNRS training workshop « electron microscopy and AFM applied to DNA-protein complexes », co-organized with the UMR 8126 of the IGR (Villejuif) or theCEMOVIS course with the University of Paris-Sud within the multi-level program in the GDR « Structural analysis in Cryo-electron Microscopy ».
At the end of 2007 the PFMU, as part of the Imagopole, has obtained the ISO 9001 certification, issued by the French Association for the Improvement and Quality management (AFAQ).
Keywords: Microscopie Electronique à Transmission et à Balayage (MET et MEB), Ultrastructure, Immunomarquage, Cryocoupes, Cryofixation, Cryomicroscopy, CEMOVIS
West NP, Sansonetti P, Mounier J, Exley RM, Parsot C, Guadagnini S, Prévost MC, Prochnicka-Chalufour A, Delepierre M, Tanguy M, Tang CM. 25 february 2005. Optimization of virulence functions through glucosylation of Shigella LPS. Science, Vol 3071313-1317 PMID: 15731456
Dramsi S, Caliot E, Bonne I, Guadagnini S, Prévost MC, Kojadinovic M, Lalioui L, Poyart C, Trieu-Cuot P.2006 Jun. Assembly and role of pili in group B streptococci. Molecular Microbiology, vol 60, No 6, pp 1401-1413. PMID: 16796677
Arhel NJ, Souquere-Besse S, Munier S, Souque P, Guadagnini S, Rutherford S, Prévost MC, Allen TD, Charneau P. 2007 Jun. HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore. EMBO J. 20;26 (12):3025-37. PMID : 17557080
Beauvais A, Schmidt C, Guadagnini S, Roux P, Perret E, Henry C, Paris S, Mallet A, Prévost MC, Latgé JP.2007 Jun. An extracellular matrix glues together the aerial-grown hyphae of Aspergillus fumigatus.Cell Microbiol.; 9(6) :1588-600. PMID : 17371405
de Jonge MI, Pehau-Arnaudet G, Fretz MM, Romain F, Bottai D, Brodin P, Honoré N, Marchal G, Jiskoot W, England P, Cole ST, Brosch R. 2007 Aug. ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. J Bacteriol.;189(16):6028-34. PMID : 17557817
Activity Reports 2007 - Institut Pasteur
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