Epidemiology of Emerging Diseases  


  HEADFONTANET Arnaud / fontanet@pasteur.fr
  MEMBERSMr CHARTIER Loïc, Dr CORDEL Hugues, Dr GARENNE Michel, Ms LECLERC Pauline, Ms LEFOULER Lenaïg, Dr MADEC Yoann, Ms PAEZ Adela, Ms PETIT Laure, Mrs REY-CUILLE Marie-Anne, Ms TAYLOR Sylvia, Mrs THEPAUT Sylvana, Mrs VRAY Muriel


  Annual Report

The Emerging Diseases Epidemiology Unit was founded on July 1st, 2001. Its mandate was to develop its own research agenda in the field of infectious diseases epidemiology, and to provide expertise in epidemiology and biostatistics to other laboratories.

Based on the potential for collaborations with the international network of Institut Pasteur, and on our past experience in international health, we decided to focus on the epidemiology of infectious and tropical diseases in resource-limited countries.

Weiss RA, Nature Medicine, 2004

Each researcher has its own field of expertise: Arnaud Fontanet in analytical epidemiology (cohort and case-control studies), Muriel Vray in the methodology of clinical trials, and Michel Garenne in demography and mathematical modeling.

All projects deal with the epidemiology of viral diseases in resource-limited countries. One common research area is HIV/AIDS. Other research areas include hepatitis C in Egypt, hepatitis B in Senegal, SARS in China, and dengue in Asia and Latin America (see websites and Figure). Emphasis has been put in clinical research, i.e., cohort studies and clinical trials on subjects infected with a pathogen. In addition, two staff members, Yoann Madec (biostatistician) and Loïc Chartier (data manager), provide transversal support to all projects of the unit.

We also offer expertise in the area of epidemiology and biostatistics to other research units of the institute and organize epidemiology and biostatistics courses. In this context, special effort has been dedicated to the preparation of epidemiology and biostatistics curricula for the Pasteur School of Infectiology and for the new Pasteur/CNAM School of Public Health (see websites below).

Keywords: epidemiology, clinical research, mathematical modeling, HIV, viral hepatitis, emerging viruses.

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  Publications

Tejiokem MC, Gouandjika I, L, MC, Tene G, GodyJC, NjamkepoE, KfutwahA, PendaI, BilongC, RoussetD, Pouillot R, Tangy F, Baril L. HIV-Infected Children Living in Central Africa Have Low Persistence of Antibodies to Vaccines Used in the Expanded Program on Immunization. PLoS ONE. 2007;2:e1260.

Madec Y, Laureillard D, Pinoges L, Fernandez M, Prak N, Ngeth C, Moeung S, Song S, Balkan S, Ferradini L, Quillet C, Fontanet A. Response to HAART among severely immuno-compromised HIV-infected patients in Cambodia. AIDS, 2007; 21:351-9.

Micol R, Lortholary O, Sar B, Laureillard D, Ngeth C, Dousset JP, Chanreoun H, Ferradini L, Guérin PJ, Dromer F, Fontanet A. Prevalence, determinants of positivity, and clinical utility of cryptococcal antigenemia in Cambodian HIV-infected patients. J. AIDS 2007;45:555-9.

Males S, Gad RR, Esmat G, Abobakr H, Anwar M, Rekacewicz C, El Hoseiny M, Zalata K, Abdel-Hamid M, Bedossa P, Pol S, Mohamed MK, Fontanet A. Serum alpha-fetoprotein (AFP) level predicts treatment outcome in chronic hepatitis C.  Antiviral therapy, Antivir Ther. 2007;12:797-803.

Vray M, Debonne JM, Sire JM, Tran N, Chevalier B, Plantier JC, Fall F, Vernet G, Simon F, Baye PS. Molecular epidemiology of hepatitis B virus in Dakar, Senegal. J Med Virol. 2006;78:329-34.



  Web Site

More informations on our web site




Activity Reports 2007 - Institut Pasteur
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