HEADDr CARNIEL Elisabeth /
  MEMBERSDr CHAUVAUX Sylvie / Dr DEMEURE Christian / Dr DERBISE Anne / FISHER Aurélie
Dr GUINET Françoise / Dr JACOB Sandrine / LANGRAND Sophie / LECLERCQ Alexandre

  Annual Report

1. Main activities

The Yersinia Research Unit was created in 2004. This Unit focuses its research activities on the genus Yersinia, which belongs to the family Enterobacteriaceae and includes three species pathogenic for humans and animals: the enteropathogens Y. pseudotuberculosis and Y. enterocolitica, and the plague agent Y. pestis.

The current activities of the Yersinia Research Unit are primarily devoted to the analysis of:

- A pathogenicity island whose presence confers to the host bacterium the ability to cause systemic infections in humans and other animals.

- The mechanisms of genetic transfer in Yersinia.

- Comparative genomics and transcriptomics in Y. pestis and Y. pseudotuberculosis.

- The molecular bases for the exceptional pathogenicity of Y. pestis after its recent emergence from Y. pseudotuberculosis.

- The pathophysiology of Yersinia infection.

- The host's mechanisms of innate and acquired immunity and the development of a plague vaccine.

- The genetic bases of susceptibility to plague.

- The resistance of pathogenic Yersinia to antibiotics and the evaluation of new treatments.

- The evolution of pathogenic Yersinia.

- The development of typing tools for molecular epidemiology.

- Public health (French Reference Center, National Surveillance Network, and WHO Collaborating Center for Yersinia).

2. Four most representative publications for the last three years (2004-2006) which have either already been published or are in press:

- P. Chain, E. Carniel, F. Larimer, J. Lamerdin, P. O. Stoutland, W. M Regala, A. M. Georgescu, L. M. Vergez, M. Land, L. V. Motin, R. R. Brubaker, J. Fowler, J. Hinnebusch, M. Marceau, C. Medigue, M. Simonet, V. Chenal-Francisque, B. Souza, D. Dacheux, J.M. Elliott, A. Derbise, L. Hauser, and E. Garcia. 2004. Insights into the genome evolution of Yersinia pestis through whole genome comparison with Yersinia pseudotuberculosis. Proc. Natl. Acad. Sci. USA. 101:13826-13831.

- B. Lesic, S. Bach, J-M. Ghigo, U. Dobrindt, J. Hacker and E. Carniel. 2004. Excision of the High-Pathogenicity Island of Yersinia pseudotuberculosis requires the combined actions of its cognate integrase and Hef, a new recombination directionality factor. Mol. Microbiol. 52:1337-1348.

- M. Achtman, G. Morelli, P. Zhu, T. Wirth, I. Diehl, D. Wagner, C. Allender, R. Easterday, V. Chenal-Francisque, P. Worsham, N. R. Thomson, J. Parkhill, L. E. Lindler, E. Carniel and P. Keim. 2004. Microevolution and history of the plague bacillus, Yersinia pestis. Proc. Natl. Acad. Sci. USA. 101:17837-17842.

- B. Lesic and E. Carniel. 2005. Horizontal transfer of the High-Pathogenicity Island of Yersinia pseudotuberculosis. J. Bacteriol. 187:3352-3358.


Publications 2006 of the unit on Pasteur's references database

Activity Reports 2006 - Institut Pasteur
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