|Stems Cells and Development - CNRS URA2578|
|HEAD||Dr TAJBAKHSH Shahragim / email@example.com|
|MEMBERS||Dr CHRETIEN Fabrice / Dr GAYRAUD-MOREL Barbara / JORY Aurélie / Dr LE ROUX Isabelle
Dr MOURIKIS Philippos / ROCHETEAU Pierre / Dr SAMBASIVAN Ramkumar
Introduction: Our aim is to characterize
stem cells and their daughters during embryonic and
postnatal development of skeletal muscle to understand
how this tissue is established, and how it regenerates
during disease, and after injury. We are examining the
genetic networks which regulate myogenic stem cell birth,
and relating this to how cell order is established in
this lineage. We are also investigating how
stem/progenitor cells self-renew, essentially via
symmetric vs. asymmetric cell divisions, and how the stem
cell niche is defined.
3) Regenerative myogenesis. Another aim is to isolate stem cells, examine their properties, and study their behavior in functional reconstitution assays by engraftment into injured dystrophic or normal muscles. These models are well established and we are investigating the roles of Pax7 and the myogenic determination genes in this context. Using genetically modified mice and specific markers, we are examining the anatomy of the muscle niche and how this may maintain the stem cell state. Collectively, these studies should provide a link between the normal development of a tissue, its deregulation during disease, and its regeneration via the recruitment of stem and progenitor cells.
References: 1) Kassar-Duchossoy et al. (2005). Genes & Dev. 2) Tajbakhsh (2005) Exp. Cell. Res. 3) Shinin et al. (2006). Nature Cell Biology.
|Publications 2006 of the unit on Pasteur's references database|
Activity Reports 2006 - Institut Pasteur
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