Urgent Response to Biological Threats

  HEADDr MANUGUERRA Jean-Claude / jmanugu@pasteur.fr
  MEMBERSBURGUIERE Ana / Dr FOUQUE Florence / Dr LECLERCQ India / LE GOUIL Meriadeg / Dr PHAN THI Nga / Dr WU Dong

  Annual Report


The Laboratory for Urgent Response to Biological Threats, called in French Cellule d’Intervention Biologique d’Urgence (CIBU), was created at the end of 2002, under the impulse of the Directorate-General of Health of the Ministry in charge of Health and the Director General of the Pasteur Institute, to respond to "specialized biological urgencies". These urgencies are dealt with in the event of epidemics, accidents, or bioterrorist attacks using biological weapons which can endanger public health.

Area of intervention

CIBU intervenes in the detection and identification of the following microbiological agents: 1/ Bacteriology: agents of botulism, anthrax, plague, and tularemia. For other bacteria, the detection and identification is performed by the Centre for Molecular Identification of Bacteria; 2/ Virology: detection of class 4 agents by molecular biology without virus amplification in cell culture (this is made to avoid working on class 4 agents without knowing so): Ebola and Marburg, Crimea Congo, Lassa and Nipah viruses. Detection of influenza A(H5N1) viruses, SARS coronavirus and orthopoxviruses. Besides intervention activities, CIBU develops research oriented activities and research projects in direct connection with its core missions.

Research oriented activities and research projects

BASE (Bac Giang Acute Syndrome of Encephalitis): The objective of this program is the molecular characterization of a potentially new virus causing encephalitis in children in North Vietnam. To this end, CIBU has been implementing non- specific molecular methodologies based on random amplification and polymorphism display followed by cloning and sequencing. BASE is a collaborative project led by the National Institute of Hygiene and Epidemiology in Hanoi, Vietnam.

EpiSARS: It is a European Union funded program coordinated by Arnaud Fontanet (Unit of Emerging Diseases Epidemiology, Institut Pasteur). EpiSARS, combining animal and human studies, aims at bringing us closer to a full understanding of the whole epidemiology of SARS-related viruses. Based on the findings of this project, original guidelines for the prevention and control of the animal reservoir will be issued, and international guidelines for the prevention and control of SARS outbreaks among humans will be strengthened. CIBU is the leader of the work package entitled ‘Virological studies’ and has focused its research in coronavirus detection and characterization in wild life animal species.

Biodiversity of viruses with epidemic potential and biorisk assessment and control: Our observation of viral biodiversity is based on a taxonomy approach and uses glass slide high density DNA microarrays (hybridization and resequencing). These are applied in the New Emerging Viral Agent Discovery and Analysis (NEVADA) and the Respiratory Syndrome DNA microarray projects. NEVADA objectives are to discover and describe viruses unknown to date. In the event of new emergence, prior knowledge resulting from preliminary discoveries should enable the quick detection of a new virus and swift and effective response and control of the new disease.


Publications 2006 of the unit on Pasteur's references database

Activity Reports 2006 - Institut Pasteur
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