|Center for the Production and Infection of Anopheles|
|HEAD||Dr BOURGOUIN Catherine / firstname.lastname@example.org|
|MEMBERS||Dr MITRI Christian / Dr THIERY Isabelle
The CEPIA, CEnter for Production and Infection of Anopheles, was created to fulfill the needs of several teams of the Institute in Anopheles mosquitoes for diverse scientific programs in Malariology (Parasitology and Entomology). The basic concept was to concentrate in a single structure the production capacity and the competences for manipulating Anopheles mosquitoes.
As the ultimate goal of many projects in Malariology is to find ways to interrupt transmission of human malaria, we also proposed to include as a specific competence of the CEPIA the production of Plasmodium falciparum gametocytes and of mosquitoes infected with this parasite species. These mosquitoes are used for studying Plasmodium-mosquito interactions and as a source of sporozoites that cannot be produced in vitro.
The objectives of the CEPIA are:
To ensure a high production of good quality mosquitoes, a quality system has been developed that includes standardized procedures for production and quality control tools, such as the survey of the receptivity of mosquitoes to a P. berghei GFP reference strain.
Since April 2006, we have been successful at establishing the routine infection of Anopheles with P. falciparum. This achievement will now permit to address several scientific issues that were usually addressed using rodent plasmodium models.
The CEPIA is also providing its expertise in molecular entomology for functional genomics in Anopheles using RNA interference.
|Publications 2006 of the unit on Pasteur's references database|
Activity Reports 2006 - Institut Pasteur
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