|Trypanosome Cell Biology - CNRS URA2581|
|HEAD||Dr BASTIN Philippe / firstname.lastname@example.org|
|MEMBERS||ABSALON Sabrina / Dr ADHIAMBO Christine / Dr BRANCHE Carole / BLISNICK Thierry
BUISSON Johanna / Dr JULKOWSKA Daria
Trypanosomes are flagellated parasites responsible for various tropical diseases, including sleeping sickness in Central Africa caused by Trypanosoma brucei. Trypanosomes also represent exciting model organisms to study as they exhibit unique cellular features and are amenable to modern reverse genetics technology. Our group is interested in two topics: (1) biology and applications of RNA interference and (2) flagellum formation and function.
Flagellum formation and functions.
Trypanosome as a model for genetic diseases. Several genetic diseases are linked to defects in cilia and flagella function. However, mammalian, insect or nematode ciliated cells do not propagate in vitro and are poorly amenable to transfection. Our data reveal that trypanosomes are an excellent model to study genetic diseases related to cilia and flagella defects. Collaborations with several medical groups studying such genetic diseases have been set up and have recently been funded by external grants.
|Publications 2006 of the unit on Pasteur's references database|
Activity Reports 2006 - Institut Pasteur
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