Unit: Cytokines and Lymphoid Development
Director: DI SANTO James
Using a genetic approach in mice, we wish to better define the roles of cytokines in lymphopoiesis, peripheral lymphoid homeostasis and during immune responses. Using an alymphoid mouse model developed in our laboratory, a series of projects address the role of different lymphoid subsets for innate immunity in the host pathogen standoff, and the role of immunosurveillance in anti-tumor immunity.
1) To elucidate the mechanisms by which a group of cytokines utilizing the common cytokine receptor γ chain (γc) promote the differentiation and homeostasis of lymphoid cells ;
2) To dissect the potential roles played by distinct lymphoid subsets during the innate response to infectious pathogens and during anti-tumor responses ;
3) To study the development and activation of Natural Killer (NK) cells using a novel alymphoid mouse model.
1. Roles for γc-dependent cytokines in the peripheral lymphoid homeostasis. (C. Vosshenrich, T. Ranson, G. Masse, J. Di Santo)
2. NK cell development and activation (C. Vosshenrich, S. Zompi, A. Caraux, F. Colucci, J. Di Santo)
3. Host pathogen interactions during bacterial and viral infections (T. Ranson, J. Di Santo, S. Zompi, A. Caraux, F. Colucci)
4. A spontaneous tumor model for dissecting anti-tumor responses in vivo (C. Vosshenrich, F. Colucci)
We believe that the projects presented herein will enhance our knowledge of the mechanisms of lymphoid development, of innate and adaptive immune responses and will furnish new animal models to study human disease processes. These projects are fundamental in nature, but have important implications for clinical medicine.
Keywords: cytokines, development, immune response, mutation, tumor, infection