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     Cytokines and Lymphoid Development


  Director : DI SANTO James (disanto@pasteur.fr)


  abstract

 

Using a genetic approach in mice, we wish to better define the roles of cytokines in lymphopoiesis, peripheral lymphoid homeostasis and during immune responses. Using an alymphoid mouse model developed in our laboratory, a series of projects address the role of different lymphoid subsets for innate immunity in the host pathogen standoff, and the role of immunosurveillance in anti-tumor immunity.



  report

cale

Objectives:

1) To elucidate the mechanisms by which a group of cytokines utilizing the common cytokine receptor γ chain (γc) promote the differentiation and homeostasis of lymphoid cells ;

2) To dissect the potential roles played by distinct lymphoid subsets during the innate response to infectious pathogens and during anti-tumor responses ;

3) To study the development and activation of Natural Killer (NK) cells using a novel alymphoid mouse model.

Ongoing projects:

1. Roles for γc-dependent cytokines in the peripheral lymphoid homeostasis. (C. Vosshenrich, T. Ranson, G. Masse, J. Di Santo)

2. NK cell development and activation (C. Vosshenrich, S. Zompi, A. Caraux, F. Colucci, J. Di Santo)

3. Host pathogen interactions during bacterial and viral infections (T. Ranson, J. Di Santo, S. Zompi, A. Caraux, F. Colucci)

4. A spontaneous tumor model for dissecting anti-tumor responses in vivo (C. Vosshenrich, F. Colucci)

Main Outcome

We believe that the projects presented herein will enhance our knowledge of the mechanisms of lymphoid development, of innate and adaptive immune responses and will furnish new animal models to study human disease processes. These projects are fundamental in nature, but have important implications for clinical medicine.

Keywords: cytokines, development, immune response, mutation, tumor, infection



  publications

puce Publications 2003 of the unit on Pasteur's references database


  personnel

  Office staff Researchers Scientific trainees Other personnel
  PHAM, Cécile, cpham@pasteur.fr COLUCCI, Francesco, CR1, Institut Pasteur, cecco@pasteur.fr

DI SANTO, James, DR2 INSERM / Chef d’Unité Institut Pasteur, disanto@pasteur.fr
CARAUX, Anouk, Etudiante en thèse

GARCIA-OJEDA, Marcos, Stagiaire post-doc

LE BARILLEC, Karine, Stagiaire post-doc

MASSE, Guillemette, Etudiante en thèse

RANSON, Thomas, Etudiant en thèse

SAMSON, Sandrine, Etudiante en thèse

SAPPEY, Olivia, Etudiante en DEA

VOSSHENRICH, Christian, Stagiaire post-doc

ZOMPI, Simona, Etudiante en thèse
CORCUFF, Erwan, technicien Institut Pasteur, ecorcuff@pasteur.fr

RICHARD-LE GOFF, Odile, technicienne Institut Pasteur, orichard@pasteur.fr

Activity Reports 2003 - Institut Pasteur
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