Overview

Our research focuses on the processing of sensory information and memory consolidation in the olfactory system. Our experimental model is the olfactory bulb, the first relay in this system. This structure, which receives massive centrifugal innervation from different brain structures involved in conditional learning as well as in memory consolidation, performs functions above and beyond the simple transmission of sensory messages. During learning, the olfactory bulb is subjected both to plastic synaptic changes and to neurogenesis related to mnesic storage. Using a pluridisciplinary approach combining molecular, cellular and behavioral levels, our goal is to determine in adult brain, how acquisition and retention of odor information can be accomplished within a neuronal network characterized by a high level of plasticity. Finally, we are currently studying some key molecules that regulate the fate of newly generated neurons. Among them, the normal form of the Prion protein (PrP^C), a signal transduction protein that primarily localized on neurites, is a good candidate. In frame with this hypothetical signaling function, we propose to evaluate the function of PrP^C on the proliferation, migration and/or differentiation of neuronal precursor in the adult brain and to characterize the morphological and functional properties of newly generated neurons expressing different levels of PrP^C in the adult CNS.

GABELLEC Marie-Madeleine,Institut Pasteur

FRATUS Laetitia, IUT Génie Biologique