|
|
OXY beta-lactamase amino-acid variation (Ambler numbering in parentheses) |
|
|
|
| Enzyme |
pI value |
2 |
4 |
9 |
11 |
12 |
15 |
16 |
17 |
22 |
24 |
25 |
29 |
30 |
31 |
32 |
33 |
34 |
38 |
39 |
43 |
44 |
54 |
56 |
58 |
61 |
75 |
90 |
91 |
92 |
101 |
102 |
103 |
111 |
129 |
140 |
141 |
143 |
156 |
161 |
168 |
171 |
174 |
180 |
184 |
194 |
200 |
230 |
233 |
240 |
256 |
261 |
262 |
270 |
275 |
278 |
Reference(s) |
Accession number(s) |
| |
|
(-) |
(-) |
(5) |
(7) |
(8) |
(11) |
(12) |
(13) |
(18) |
(20) |
(21) |
(25) |
(26) |
(27) |
(28) |
(29) |
(30) |
(34) |
(35) |
(39) |
(40) |
(50) |
(52) |
(54) |
(56) |
(72) |
(87) |
(88) |
(89) |
(98) |
(99) |
(100) |
(108) |
(126) |
(137) |
(138) |
(140) |
(153) |
(158) |
(165) |
(168) |
(171) |
(177) |
(181) |
(190) |
(197) |
(227) |
(230) |
(237) |
(255) |
(260) |
(261) |
(269) |
(274) |
(277) |
|
(Reference) |
| OXY-1-1 |
7.5 |
L |
S |
T |
L |
M |
A |
A |
V |
A |
G |
S |
S |
A |
D |
A |
I |
Q |
A |
D |
R |
S |
N |
A |
D |
T |
G |
N |
P |
E |
K |
K |
S |
I |
A |
K |
M |
S |
Q |
V |
T |
A |
S |
K |
T |
R |
N |
A |
A |
A |
N |
V |
L |
Q |
S |
E |
1 |
Z30177 |
| OXY-1-2 |
7.7 |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
V |
G |
. |
. |
. |
. |
. |
. |
5 |
AJ871864, AJ871865 |
| OXY-1-3 |
N. A. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
G |
. |
. |
. |
. |
. |
. |
2 |
AY077482 |
| OXY-1-4 |
N. A. |
. |
. |
. |
. |
. |
. |
del |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
V |
. |
. |
. |
. |
. |
. |
. |
2 |
AY077483 |
| OXY-1-5 |
N. A. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
V |
G |
. |
. |
. |
. |
. |
. |
2 |
AYO77486 |
| OXY-1-6 |
5.25 |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
P |
. |
. |
K |
3 |
Y17715 |
| OXY-1-7 |
7.4 |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
4 |
M27459 |
| OXY-2-1 |
N. A. |
I |
. |
I |
M |
L |
. |
del |
. |
. |
. |
A |
. |
T |
. |
. |
. |
H |
T |
. |
. |
. |
. |
. |
N |
I |
S |
. |
K |
. |
N |
A |
A |
. |
T |
L |
I |
G |
H |
A |
. |
T |
T |
E |
S |
. |
D |
E |
V |
. |
D |
. |
. |
. |
N |
. |
5 |
AJ871866 |
| OXY-2-2 |
N. A. |
I |
. |
I |
M |
L |
. |
del |
. |
. |
. |
A |
. |
T |
. |
. |
. |
H |
T |
. |
. |
. |
. |
. |
N |
I |
S |
. |
K |
. |
N |
A |
A |
. |
T |
L |
I |
G |
R |
A |
. |
T |
T |
E |
S |
. |
D |
E |
V |
. |
D |
I |
. |
. |
N |
. |
5 |
AJ871867 |
| OXY-2-3 |
N. A. |
I |
. |
I |
M |
L |
del |
del |
. |
. |
. |
A |
. |
T |
. |
. |
. |
H |
T |
. |
. |
. |
. |
. |
N |
I |
S |
. |
K |
. |
N |
A |
A |
. |
T |
L |
I |
G |
R |
A |
. |
T |
T |
E |
S |
. |
D |
E |
V |
G |
D |
. |
. |
. |
N |
. |
2 |
AY077488 |
| OXY-2-4 |
N. A. |
I |
. |
I |
M |
L |
del |
del |
. |
. |
. |
A |
. |
T |
. |
. |
. |
H |
T |
. |
. |
. |
. |
. |
N |
I |
S |
. |
K |
. |
N |
A |
A |
. |
T |
L |
I |
G |
R |
A |
. |
T |
T |
E |
S |
. |
D |
E |
V |
. |
D |
. |
. |
. |
N |
. |
3 |
Y17714 |
| OXY-2-5 |
N. A. |
I |
. |
I |
M |
L |
del |
del |
. |
. |
. |
A |
. |
T |
. |
. |
. |
H |
T |
. |
. |
. |
. |
. |
N |
I |
S |
. |
K |
. |
N |
A |
A |
. |
T |
L |
I |
G |
R |
A |
. |
T |
T |
E |
S |
. |
D |
E |
V |
. |
D |
. |
. |
. |
N |
. |
2 |
AY077487 |
| OXY-2-6 |
N. A. |
I |
. |
I |
M |
L |
. |
del |
. |
. |
S |
A |
. |
T |
. |
. |
. |
H |
T |
. |
. |
. |
. |
. |
N |
I |
S |
. |
K |
. |
N |
A |
A |
. |
T |
L |
I |
G |
R |
A |
. |
T |
T |
E |
S |
. |
D |
E |
V |
. |
D |
. |
. |
. |
N |
. |
2 |
AY077485 |
| OXY-2-7 |
N. A. |
I |
. |
I |
M |
L |
. |
del |
. |
. |
. |
A |
. |
T |
. |
. |
. |
H |
T |
. |
. |
. |
. |
. |
N |
I |
S |
. |
K |
. |
N |
A |
A |
. |
T |
L |
I |
G |
R |
A |
. |
T |
T |
E |
S |
. |
D |
E |
V |
. |
D |
. |
. |
. |
N |
. |
1 |
Z49084 |
| OXY-2-8 |
N. A. |
I |
. |
I |
M |
L |
. |
del |
. |
. |
S |
A |
. |
T |
. |
. |
. |
H |
T |
. |
. |
. |
. |
. |
N |
I |
S |
. |
K |
. |
N |
A |
A |
. |
T |
L |
I |
G |
R |
A |
. |
T |
T |
E |
S |
. |
. |
E |
V |
. |
. |
. |
. |
. |
N |
. |
6 |
AY055205 |
| OXY-3-1 |
6.7 |
I |
T |
S |
. |
I |
. |
del |
L |
C |
S |
. |
del |
del |
N |
. |
. |
. |
. |
. |
S |
T |
D |
T |
N |
I |
. |
. |
K |
D |
. |
A |
. |
V |
. |
. |
. |
G |
R |
. |
. |
. |
T |
E |
. |
H |
. |
. |
V |
. |
. |
. |
. |
L |
. |
D |
2 |
AF491278 |
| OXY-4-1 |
7.7 |
. |
. |
S |
. |
. |
. |
del |
. |
. |
. |
. |
. |
. |
. |
T |
L |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
H |
. |
D |
. |
. |
. |
. |
. |
. |
I |
G |
. |
. |
M |
. |
. |
. |
. |
. |
. |
. |
. |
G |
. |
. |
. |
. |
. |
. |
2 |
AY077481 |
| OXY-5-1 |
7.2 |
. |
. |
. |
. |
. |
. |
del |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
H |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
A |
. |
. |
. |
I |
G |
. |
. |
M |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
5 |
AJ871868, AJ871869, AJ871870, AJ871872 |
| OXY-5-2 |
7.7 |
. |
. |
. |
. |
. |
. |
del |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
A |
. |
. |
. |
I |
G |
L |
. |
M |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
5 |
AJ871871 |
| OXY-6-1 |
7.75 |
. |
. |
S |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
H |
. |
D |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
5 |
AJ871873, AJ871874 |
| OXY-6-2 |
7.75 |
. |
. |
S |
. |
. |
. |
del |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
H |
. |
D |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
5 |
AJ871875 |
| OXY-6-3 |
7.75 |
. |
. |
S |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
T |
|
. |
. |
H |
. |
D |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
5 |
AJ871876 |
| OXY-6-4 |
8.1 |
. |
. |
S |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
N |
. |
. |
. |
. |
. |
. |
. |
H |
. |
D |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
5 |
AJ871877, AJ871878, AJ871879 |
| 1 - Fournier B., Lu C.Y., Lagrange P.H., Krishnamoorthy R. and Philippon A. 1995. Point mutation in the pribnow box, the molecular basis of beta-lactamase overproduction in Klebsiella oxytoca. Antimicrob. Agents
Chemother. 39:1365-68. |
|
|
| 2
- Granier S.A., Plaisance L., Leflon-Guibout V., Lagier E., Morand S.,
Goldstein F.W. and Nicolas-Chanoine M.H. 2003. Recognition of two genetic
groups in the Klebsiella oxytoca taxon on the basis of chromosomal
beta-lactamase and housekeeping gene sequences as well as ERIC-1R PCR typing.
Int. J. Syst. Evol. Microbiol. 53:661-8. |
|
| 3
- Wu S.W., Dornbusch K. and Kronvall G. 1999. Genetic characterization of
resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates
recovered from patients with septicemia at hospitals in the Stockholm area.
Antimicrob. Agents Chemother. 43:1294-1297. |
|
| 4
- Arakawa Y., Ohta M., Kido N., Mori M., Ito H., Komatsu T., Fujii Y. and
Kato N. 1989. Chromosomal beta-lactamase of Klebsiella
oxytoca, a new class A enzyme that hydrolyzes
broad-spectrum beta-lactam antibiotics. Antimicrob. Agents Chemother. 33 (1),
63-70. |
|
| 5
- Fevre C., Jbel M., Passet V., Weill F.X., Grimont P.A.D. and Brisse S.
2005. Six Groups of the OXY ß-Lactamase Evolved over Millions of Years in
Klebsiella oxytoca. Antimicrob. Agents
Chemother. 49:3453-3462. |
|
| 6
- Granier S.A., Leflon-Guibout V., Nicolas-Chanoine M.H., Bush K. and
Goldstein F.W. 2002. The extended-spectrum K1 beta-lactamase from Klebsiella oxytoca SC10,436 is a
member of the bla(OXY-2) family of chromosomal Klebsiella enzymes. Antimicrob. Agents Chemother. 46:2056-7. |
|
| N.A.:
Not Available |
|
| del:
Deletion |
|
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