Major achievements in the last five years
The major achievements on the last five years are the following: (1) the role of dermal cells in the pathogenicity of flaviviruses, (2) the role of dynein light chain Tctex-1 in the late stages of flavivirus replication, (3) the role of the IFN-inducible 2',5'-Oligoadenylate Synthetases (OAS) in the host cell defences against arboviruses, (4) identification of viral determinants that enable subversion of WN, YF and CHIK viruses towards OAS, (5) development of immunotherapeutic tools as well as dengue, West Nile and Chikungunya vaccines using non-replicative lentivirus vector and live-attenuated measles virus, and (6) development of innovative biotechnologies for improving molecular detection of arboviruses and serodiagnosis of virus-related diseases.
• Molecular Virology
• Interactions virus/host-cell (vertebrates and invertebrates)
• Viral pathogenicity towards antiviral innate immunity
• Pathogenesis of arbovirus infection
• Development of new diagnosis tools
• Development of candidate vaccines against arboviruses
The FHMI lab is sharing with the CIBU (JC. Manugerra) and Antiviral Strategies lab (N. Tordo), the WHO Collaborating Centre for Reference and Research on Arboviruses and Viral Haemorrhagic Fevers and the OIE Collaborating Centre for Rift Valley Fever and Crimean-Congo Hemorrhagic Fever viruses at the Institut Pasteur.
The FHMI team is widely involved in the teaching of PhD students in virology and training of medical virologists or clinicians in France and Europe (EU FP-7 program EPISOUTH Plus) in link with the International Network of Instituts Pasteur.
Training experiences 2007-2012
Master students 5 completed
PhD students 4 completed
Post-doctoral scientists 5 completed 2 current
Grant income in 2012
• European Program FP_7-Health EUROWESTNILE) "European West Nile collaborative research project"
• European Program FP-7-Health EMPERIE "European Management Platform for Emerging and Reemerging Infectious disease
• European Program FP-7-Health PREDEMICS "Prediction and Prevention of Emerging Zoonotic Viruses with Pandemic Potential using Multidisciplinary Approaches"
• French National Agency of Research’s grant ARBOAS "Deciphering the role of Human OAS gene family in the pathogenesis of
• French National Agency of Research’s grant KerARBO "Role of salivary factors of Aedes albopictus in the permissiveness of human
skin cells to Dengue and Chikungunya viruses"