PUBLICATIONS

2007

  • X. Zhang, E. Deriaud, X. Jiao, D. Braun, C. Leclerc and R. Lo-Man. Type I interferons cooperate with regulatory B cells to protect neonates from acute inflammation.
    J. Exp. Med.,  2007, 204, 1107-1118.

  • S. Hervas-Stubbs, F. Boisgerault, N. Thieblemont and C. Leclerc. TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help. Blood, 2007, 109, 5318-5326.
  • P. Berraondo, C. Nouze, X. Preville, D. Ladant and C. Leclerc. Erradication of large tumors in mice by a tritherapy targeting the innate, adaptive and regulatory components of the immune system. Cancer Research, 2007, 67, 8847-8855.
  • J.J. Lasarte, N. Casares, M. Gorraiz, S. Hervas-Stubbs, L. Arribillaga, C. Mansilla, D. Llopiz, P. Sarobe, F. Borras-Cuesta, J. Prieto and C. Leclerc. The Extra Domain A from fibronectin targets antigens to Toll like receptor 4 expressing cells and induces cytotoxic T cell responses in vivo. J. Immunol., 2007, 178, 748-756.
  • S. Hervas-Stubbs, P. Rueda, L. Lopez and C. Leclerc. Insect baculovirus strongly potentiate adaptive immune responses through the induction of type 1 interferon. J. Immunol. 2007, 178, 2361-2369.
  • L. Majlessi, B. Combaluzier, I. Albrecht, J.E. Garcia, C. Nouze, J. Pieters and C. Leclerc. Inhibition of phagosome maturation by Mycobacteria does not interfere with presentation of mycobacterial antigens by MHC molecules.
    J. Immunol., 2007, 179, 1825-1833.
  • T.G. Connell, M.S. Shey, R. Seldon, M.X. Rangaka, G. Van Cutsem, M. Simsova, Z. Marcekova, P. Sebo, N. Curtis, L. Diwakar, G.A. Meintjes, C. Leclerc, R.J. Wilkinson and K.A. Wilkinson. Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in HIV infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector. Clinical and Vaccine Immunology, 2007, 14, 847-854.

2006

  • J.Y. Bertrand, G.E. Desanti, R. Lo-Man, C. Leclerc, A. Cumano and R. Golub. Fetal spleen stroma drives macrophage commitment. Development, 2006, 133, 3619-3628.
  • C. Rybner-Barnier, C. Jacquemot, C. Cuche, G. Dore, L. Majlessis, M.M. Gabellec, A. Moris, O. Schwartz, J. Di Santo,  A. Cumano, C. Leclerc AND F. Lazarini. Processing of the bovine spondiform encephalopathy-specific prion protein by dendritic cells. J. Virol., 2006, 80, 4656-4663.
  • P. Brodin, L. Majlessi, L. Marsollier, M.I. De Jonge, D. Bottai, C. Demangel, J. Hinds, O. Neyrolles, P.D. Butcher, C. Leclerc,  S. Cole and R. Brosch. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis  and impact on immunogenicity and virulence. Inf. Immunity, 2006, 74, 88-98.
  • L. Majlessi, M. Simsova, Z. Jarvis, P. Brodin, M.J. Rojas, C. Bauche, C. Nouze,  D. Ladant, S.T. Cole, P. Sebo and C. Leclerc. An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis. Inf. Immunity, 2006, 74, 2128-2137.
  • S. Hervas-Stubbs, L. Majlessi, M. Simsova, J. Morova, M.J. Rojas, C. Nouze, P. Brodin, P. Sebo and C. Leclerc. High frequency of CD4+ T-cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection. Inf. Immunity, 2006, 74, 3396-3407.
  • T. Freire, R. Lo-Man, F. P, V. Piller, C. Leclerc and S. Bay. Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for anti-tumor vaccination. Glycobiology, 2006, 16, 390-401.
  • G. Schlecht, J. Mouriez, M. Poitrasson-Rivière, C. Leclerc and G. Dadaglio. Purification of splenic dendritic cells induces maturation and capacity to stimulate Th1 response in vivo. Int. Immunol., 2006, 18, 445-452.
  • L. Mascarell, C. Bauche, C. Fayolle, O. M. Diop, M. Dupuy, N. Nougarede, R. Perrault, D. Ladant and C. Leclerc. Delivery of the HIV-1 TAT protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates. Vaccine, 2006, 24, 3490-3499.

2005

  • C.M. Sun, E. Deriaud, C. Leclerc  and R. Lo-Man. Upon TLR9 signaling, B cells controls the IL-12-dependent Th1-priming capacity of neonatal DCs. Immunity, 2005, 22, 467-477.
  • X. Preville, D. Ladant, B. Timmerman and C. Leclerc. Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein. Cancer Research, 2005, 65, 641-649.
  • F. Boisgerault, P. Rueda, C.M. Sun, S. Hervas-Stubbs, M. Rojas and C. Leclerc. Cross-priming of T cell responses by synthetic microspheres carrying a CD8+ T cell epitope requires an adjuvant signal. J. Immunol., 2005, 174, 3432-3439.
  • L. Majlessi, P. Brodin, R. Brosch, M.J. Rojas, H. Khun, M. Huerre, S.T. Cole and C. Leclerc. Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system.
    J. Immunol., 2005, 174, 3570-3579.
  • P. Brodin, M.I. De Jonge, L. Majlessi, C. Leclerc, M Nilges, S.T. Cole and R. Brosch. Functional analysis of Early Secreted Antigenic Target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involced in secretion, complex formation, virulence and immunogenicity. J. Biol. Chem., 2005, 280, 33953-33959.
  • L. Mascarell, C. Fayolle, C. Bauche, D. Ladant and C. Leclerc. Induction of neutralizing antibodies, Th1 polarized and CD4-independent CD8+ T-cell responses following the delivery of HIV-1 Tat protein by recombinant adenylate cyclase of Bordella pertussis. J. Virol., 2005, 179, 9872-9884.
  • J. Masin, M. Basler, O. Knapp, M. El-Azami-El-Idrissi, E. Maier, I. Konopasek, R. Benz, C. Leclerc and P. Sebo. Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on cCD11b-expressing cells
    Biochemistry, 2005, 44, 12759-12766.
  • K.A. Wilkinson, M. Simsova, E. Scholvinck, P. Sebo, C. Leclerc, H.M. Vordermeier, S.J. Dickson, R.N. Davidson, G. Pasvol, M. Levin and R.J. Wilkinson. Efficient ex vivo restimulation of Mycobacterium tuberculosis- specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids. Inf. Immunity, 2005, 73, 2991-2998.
  • S. Grigalevicius, S. Chierici, O. Renaudet, R. Lo-Man, E. Deriaud, C. Leclerc and P. Dumy. Chemoselective assembly and immunological evaluation of multiepitopic glycoconjugates bearing clustered Tn antigen as synthetic anticancer vaccines. Bioconjugate Chemistry, 2005, 16, 1149-1159.

2004

  • B. Adkins, C. Leclerc and S. Marshall-Clarke. Neonatal adaptive immunity comes of age. Nature Rev. Immunol., 2004, 4, 553-564
  • V.G. Moron, G. Dadaglio and C. Leclerc. New tools for antigen delivery to the MHC class I pathway. Trends in Immunology, 2004, 25, 92-97.
  • G. Schlecht, S. Garcia, N. Escriou, A A. Freitas, C. Leclerc and G. Dadaglio. Murine plasmacytoid dendritic cells induce effector/memory CD8+T-cell responses in vivo after viral stimulation. Blood, 2004, 104, 1808-1815.
  • R. Lo-Man, S. Vichier-Guerre, R. Perraut, E. Deriaud, V. Huteau, L. Benmohamed, O.M. Diop, P.O. Livingston, S. Bay and C. Leclerc. A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor specific antibodies in non-human primates. Cancer Research, 2004, 64, 4987-4994.
  • M. Regner, X. Martinez, E. Belnoue, C.M. Sun, F. Boisgerault, P.H. Lambert, C. Leclerc and C.A. Siegrist. Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheres. J. Immunol., 2004, 173, 2669-2674.
  • G. Schlecht, J. Loucka, H. Najar, P. Sebo and C. Leclerc. Antigen targeting to CD11b allows efficient presentation of CD4+ and CD8+ T cell epitopes and in vivo Th1 polarized T-cell priming. J. Immunol., 2004, 173, 6089-6097.
  • P. Brodin, L. Majlessi, R. Brosch, D. Smith, G. Bancroft, S. Clarck, A. Williams, C. Leclerc and S.T. Cole. Enhanced protection against Tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against Region of Difference 1 Antigens. J. Infectious Diseases, 2004, 190, 115-122.
  • C. Demangel, P. Brodin, P. Cockle, R. Brosch, L. Majlessi, C. Leclerc and S.T. Cole. Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenecity independently of a 10-kilodalton culture filtrate protein and ESAT-6. Infect. Immun., 2004, 72, 2170-2176.
  • H.M. Vordermeier, M. Simsova, R.J. Wilkinson, R.G. Hewinson, P. Sebo and C . Leclerc. Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase (CyaA) by T cells from cattle with bovine tuberculosis. Inf. Immunity, 2004, 72, 6255-6261
  • P. Rueda, G. Moron, J. Sarraseca, C. Leclerc and J.I. Casal. Influence of flanking sequences on the processing and presentation of a CD8+ cytotoxic T-cell epitope delivered by parvovirus-like particles. J. Gen. Virol., 2004, 85, 563-572.
  • C. Fayolle, C. Bauche, D. Ladant and C. Leclerc. Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells in vivo. Vaccine, 2004, 23, 604-614.
  • S. Vichier-Guerre, R. Lo-Man, V. Huteau, E. Deriaud, C. Leclerc and S. Bay. Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn-antigene. Bioorg Med Chem Lett. , 2004, 14, 3567-3570.

2003

  • AS. Pym*, P. Brodin*, L. Majlessi*, R. Brosch, C. Demangel, A. Williams, K.E. Griffiths, G. Marchal, C. Leclerc and S.T. Cole (* Equal contribution). Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis.
    Nature Medecine, 2003, 9, 533-539.
  • C.M. Sun, L. Fiette, M. Tanguy, C. Leclerc and R. Lo-Man. Ontogeny and innate properties of neonatal dendritic cells. Blood, 2003, 102, 585-589.
  • X. Jiao, R. Lo-Man, N. Winter, E. Deriaud, B. Gicquel and C. Leclerc. The shift of Th1 to Th2 immunodominance associated with the chronicity of M. bovis BCG infection does not affect the memory response. J. Immunol, 2003, 170, 1392-1398.
  • V.G. Moron, P. Rueda, C. Sedlik and C. Leclerc. In vivo, dendritic cells cross-present virus-like particles using an endosome-to-cytosol pathway. J. Immunol., 2003, 171, 2242-2250.
  • M. El-Azami-El-Idrissi, C. Bauche, J. Loucka, R. Osicka, P. Sebo, D. Ladant and C. Leclerc. Interaction of Bordetella adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain.
    J. Biol. Chem., 2003, 278, 38514-38521.
  • L. Majlessi, M.J. Rojas, P. Brodin and C. Leclerc. CD8+T-cell responses of mycobacteria-infected mice to a newly identified MHC-I-restricted epitope shared by proteins of ESAT-6 family. Inf. Immun., 2003, 71, 7173-7177.
  • G. Dadaglio, S. Morel, C. Bauche, Z. Moukrim, F.A. Lemonnier, B.J. van den Eynde, D. Ladant and C. Leclerc. Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes. Int. Immunol, 2003, 15, 1423-1430.
  • N. Haicheur, F. Benchetrit, E. Bismuth, C. Leclerc, T. Falguieres, C. Fayolle, M. Amessou, W.H. Fridman, L. Johannes AND E. Tartour. The B-subunit of Shiga toxin coupled to full size antigenic protein elicits humoral and cellular immune responses associated with a TH1 dominant polarization. Int. Immunol., 2003, 15, 1161-1171.
  • X. Martinez, M. Regner, J. Kovarik, S. Zarei, C. Hauser, P.H. Lambert, C. Leclerc and C.A. Siegrist. CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particles.
    Virology, 2003, 305, 428-435.
  • S. Vichier-Guerre, R. Lo-Man, L. Benmohamed, E. Deriaud, S. Kovats, C. Leclerc and S. Bay. Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: A potential anti-cancer vaccine for human use. J. Pep. Res., 2003, 62, 117-124.

2002

  • G. Moron, P. Rueda, I. Casal and C. Leclerc
    CD8a- CD11b+ dendritic cells present exogenous virus-like particles (VLPs) to CD8+ T cells and subsequently express CD8__ and DEC205 molecules.
    J. Exp. Med. 2002, 195, 1233-1245.