• Thiriot, A., Drapier, A.-M., Vieira, P., Fitting, C., Cavaillon, J.-M., Cazenave, P.-A. & Rueff-Juy, D. The Bw cells, a novel B cell population conserved in the whole genus Mus. J. Immunol. 179 : 6568-6578 (2007)
  • Sanchez-Guajardo, V., Tanchot, C., O’Malley, J.T., Kaplan, M.H., Garcia, S. & Freitas, A.A. Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6. J. Immunol. 178 : 7550-7556 (2007)


  • Almeida, ARM., Zaragoza, B. & Freitas A.A. Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells. Int. Immunol 18 : 1607-1613 (2006)
  • Hao Y., Legrand L. & Freitas AA. The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J. Exp. Med. 203 : 1643-1649 (2006)
  • Almeida ARM, Zaragoza B. & Freitas AA. Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2 producing cells.
    J. Immunol. 177 : 192-200 (2006)
  • Mascarell, L., Auger, R., Kanellopoulos, J.M. & Truffa-Bachi, P.  The usage of alternative splice sites in mus musculus synaptotagmin-like 2 gene is modulated by cyclosporin A and FK506 in T-lymphocytes. Mol Immunol. 43 : 1846 – 1854 (2006)
  • De la Coste, A. & Freitas, A.A. Notch signaling : distinct ligands induce specific signals during lymphocyte development and maturation. Immunol letters 102 : 1-9 (2006)


  • Wildin, R.S. & Freitas, A. IPEX and Foxp3 : clinical and research perspectives.  J. Autoimmunity 25 : 56-62 (2005)
  • Marquez M.-E., Ellmeier W., Sanchez-Guajardo V., Freitas A.A., Acuto O. & Di Bartolo V. T cell sensory adaptation dependent on  TCR  avidity for self-antigens. J. Immunol. 175 : 7388-7397 (2005).

  • Ghiringhelli, F., Ménard, C., Terme M., Flament, C., Taieb, J., Chaput, N., Puig, P.E., Novault, S., Escudier, B., Vivier, E., Lecesne, A., Robert, C., Blay, J.-Y., Caillat-Zucman, S., Freitas, A., Tursz, T., Wagner-Ballon, O., Capron, C., Vainchencker, W., Martin, F. & Zitvogel, L. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-b-dependent manner.  J. Exp. Med. 202 : 1075-1085 (2005)
  • Agenes, F., Bosco, N., Mascarell, L., Fritah, S. & Ceredig, R. Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cells. Immunology 115 : 179-188 (2005)
  • Almeida, A.R.M., Rocha, B., Freitas, A..A & Tanchot, C. Homeostasis of T cell numbers : from thymus production to peripheral compartmentalization and the indexation of regulatory T cells. Sem. Immunol. 17 : 239-249 (2005)
  • De La Coste, A., Six, E., Fazilleau, N., Mascarell L., Legrand, N., Mailhe, M.-P., Cumano, A., Laabi, Y. & Freitas, A.A. In vivo and in absence of a thymus the enforced expression of the Notch ligands Delta-1 or Delta-4 promotes T cell development with specific unique effects.  J. Immunol. 174 : 2730-2737 (2005)
  • Sanchez-Guajardo, V., Borghans, J.A.M., Marquez, M.-E., Garcia, S. & Freitas, A.A. Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphopenia-driven proliferation. J. Immunol.  174 : 1178-1187 (2005)


  • Schlecht, G., Garcia, S., Escriou, N., Freitas, A.A., Leclerc C. & Dadaglio, G. Murine plasmacytoid dendritic cells Cs induce effector/memory CD8+ T cells responses in vivo after viral stimulation. Blood 104 : 1808-1815 (2004)
  • Mascarell, L. & Truffa-Bachi, P. T lymphocyte activation initiates the degradation of the CD62L encoding mRNA and increases the transcription of the corresponding gene. Immunol. Letters 94 : 115-122 (2004)
  • Mascarell, L., Auger, R., Alcover, A., Ojcius, D.M., Jungas, T., Cadet-Daniel, V., Kanellopoulos, J.M. & Truffa-Bachi, P. Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cells. J. Biol. Chem. 279 : 10556-10563 (2004)

  • Gaudin, E., Hao, Y., Rosado, M.M., Chaby, R., Girard, R. & Freitas, A.A. Positive selection of B cells expressing low densities of self-reactive BCRs. J. Exp. Med. 199 : 843-853 (2004)
  • Borghans, J.A.M., Beltman, J.B. & De Boer, R.J. MHC polymorphism under host-pathogen coevolution. Immunogenetics 55 : 732- 739 (2004)
  • De Boer R.J., Borghans, J.A.M., van Boven, M., Kesmir, C. & Weissing, F.J. Heterozygote advantage fails to explain the high degree of polymorphism of the MHC. Immunogenetics 55 : 725-731 (2004)
  • Gaudin, E., Rosado, M., Agenes, F., McLean, A. & Freitas, A.A.  B-cell homeostasis, competition, resources, and positive selection by self-antigens. Immunol. Rev. 197 : 102-115 (2004)


  • Borghans, J.A.M., Noest, A.J. & De Boer R.J. Thymic selection does not limit the individual MHC diversity. Eur. J. Immunol. 33 : 3353-3358 (2003)
  • Mascarell, L., & P. Truffa-Bachi. New aspects of cyclosporin A mode of action: from gene silencing to gene up-regulation. Mini Rev. Med. Chem 3 : 207-216: (2003)


  • Almeida, A.R.M., Legrand, N., Papiernick, M. & Freitas, A.A. Homeostasis of peripheral CD4+ T cells : IL-2R_ and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169 : 4850-4860 (2002)


  • Almeida, A.R.M., Borghans, J.A.M. & Freitas, A.A. T cell homeostasis : thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors.  J. Exp. Med.194 : 591-599 (2001)