Unité de Biochimie des Interactions Macromoléculaires



  • Fayolle, C., Davi M., Dong H., Ritzel D., Le Page A., Knipping F., Majlessi L., Ladant D., and C. Leclerc. 2010. Induction of anti-Tat neutralizing antibodies by the CyaA vector targeting dendritic cells:influence of the insertion site and of the delivery of multicopies of the dominant Tat B-cell epitope. Vaccine (in press).
  • Karst, J. C., Sotomayor Perez A.C., Guijarro J.I., Raynal B., Chenal A. and D. Ladant. 2010. Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin. Biochemistry 49:318-328.
  • Knapp, O., Maier E., Mkaddem S.B., Benz R., Bens M., Chenal A., Geny B., Vandewalle A. and M. R. Popoff. 2010. Clostridium septicum alpha-toxin forms pores and induces rapid cell necrosis. Toxicon 55:61-72.
  • Laine, E., Goncalves C., Karst J. C., Lesnard A., Rault S., Tang W. J., Malliavin T. E., Ladant, D. and A. Blondel. 2010. Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor. Proceedings of the National Academy of Sciences of the United States of America 107:11277-11282.
  • Postic G., Danchin A., and U. Mechold,  2010. Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae. Symplectic Biology (in press)
  • Sotomayor Perez, A. C., Karst J.C, Davi M., Guijarro J.I., Ladant D. and A. Chenal. 2010. Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the Bordetella pertussis adenylate cyclase toxin. Journal of Molecular Biology 397:534-549.
  • Ullmann, A. 2010. Jacques Monod, 1910-1976: his life, his work and his commitments. Research in Microbiology 161:68-73.


  • RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion. Chenal A., Ladant D., Delepierre M., Inaki Guijarro J., Raynal B. The Journal of Biological Chemistry 284, 3 (2009) 1781-9
  • The Adenylate Cyclase Toxins of Bacillus anthracis and Bordetella pertussis Promote Th2 Cell Development by Shaping T Cell Antigen Receptor Signaling. Paccani, SR; Benagiano, M; Capitani, N, et al. PLOS PATHOGENS   Volume: 5   Issue: 3
  • Characterization of YmgF, a 72-Residue Inner Membrane Protein That Associates with the Escherichia coli Cell Division Machinery. Karimova, G; Robichon, C; Ladant, D. JOURNAL OF BACTERIOLOGY   Volume: 191   Issue: 1   Pages: 333-346
  • Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis. Bourdeau, RW; Malito, E; Chenal, A, et al. JOURNAL OF BIOLOGICAL CHEMISTRY   Volume: 284   Issue: 21   Pages: 14645-14656   Published: 2009
  • Side Chain Resonances in Static Oriented Proton-Decoupled N-15 Solid-State NMR Spectra of Membrane Proteins. Aisenbrey, C; Prongidi-Fix, L; Chenal, A, et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   Volume: 131   Issue: 18   Pages: 6340


  • Interaction Network among Escherichia coli Membrane Proteins Involved in Cell Division as Revealed by Bacterial Two-Hybrid Analysis (vol 187, pg 2233, 2005). Karimova, G; Dautin, N; Ladant, D. JOURNAL OF BACTERIOLOGY   Volume: 190   Issue: 24   Pages: 8248-8248
  • Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis .Paccani, SR; Dal Molin, F; Benagiano, M, et al. INFECTION AND IMMUNITY   Volume: 76   Issue: 7   Pages: 2822-2832
  • Binding of the Unorthodox Transcription Activator, Crl, to the Components of the Transcription Machinery. England, P; Westblade, LF; Karimova, G, et al. JOURNAL OF BIOLOGICAL CHEMISTRY   Volume: 283   Issue: 48   Pages: 33455-33464
  • Membrane interaction of botulinum neurotoxin A translocation (T) domain - The belt region is a regulatory loop for membrane interaction. Galloux, M; Vitrac, H; Montagner, C, et al. JOURNAL OF BIOLOGICAL CHEMISTRY   Volume: 283   Issue: 41   Pages: 27668-27676


  • Eradication of Large Tumors in Mice by a Tritherapy Targeting the Innate, Adaptive, and Regulatory Components of the Immune System. P. Berraondo, C. Nouzé, X. Préville, D. Ladant, and C. Leclerc Cancer Research67:8847-8855 (PMID: 17875726)
  • The Escherichia coli regulator of sigma 70 protein, Rsd, can up-regulate some stress-dependent promoters by sequestering sigma 70. Mitchell, JE; Oshima, T; Piper, SE, et al. JOURNAL OF BACTERIOLOGY   Volume: 189 Issue: 9   Pages: 3489-3495


  • In vitro acylation of neurocalcin, exploration of membrane binding properties using surface plasmon resonance. Ladant D., Rossi C., Beven L., Chopineau J. Neuronal calcium sensors proteins. 351-370
  • Structural and functional characterization of an essential RTX sub-domain of Bordetella pertussisadenylate cyclase toxin. C. Bauche, A. Chenal, O. Knapp, C. Bodenreider, R. Benz, A. Chaffotte, and D. Ladant J Biol Chem. 281 :16914-16926 (PMID: 16627468)
  • Cell entry and cAMP imaging of anthrax edema toxin. F. Dal Molin, F. Tonello, D. Ladant, I. Zornetta, I. Zamparo, G. Di Benedetto, M. Zaccolo, and C. Montecucco  EMBO. J. 25:5405-5413 (PMID: 17082768)


  • Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis. G. Karimova, N. Dautin, and D. Ladant  (2005) J. Bact.. 187:2233-2243(PMID: 15774864)
  • Differential mechanism for calcium-dependent protein/membrane association as evidenced from SPR-binding studies on supported biomimetic membranes. Rossi C., Homand J., Bauche C., Hamdi H., Ladant D., Chopineau J. Biochemistry. 42 (2003) 15273-15283