Research Interests - David Ribet
Ph.D.- Post-doctoral Fellow
Characterization of SUMOylations/deSUMOylations induced by Listeria monocytogenes and their roles in bacterial infection
My research studies are focused on the impact of Listeria monocytogenes on the SUMOylation machinery of the infected cell, and the impact of SUMOylation on infection. SUMOylation consists in the reversible modification of a target protein by the covalent fixation of an ubiquitin-like protein called SUMO. SUMO-modified proteins disclose altered properties and are involved in many essential cellular processes like regulation of transcription, nucleocytoplasmic transport, DNA repair, protein stability, and stress response. The impact of pathogenic bacteria like Listeria on these specific post-translational modifications remains yet completely unknown.
My aims are to identify cellular or bacterial proteins specifically SUMOylated or deSUMOylated upon infection by L. monocytogenes, and to understand the roles of these modifications in the life cycle of this pathogen.