Recherche / Départements scientifiques / Biologie cellulaire et infection / Unités et groupes / Unité des Interactions Bactéries-Cellules / Team

Curriculum vitae - Ascel Régis Samba-Louaka

Citizenship:  French

Professional address:

INSTITUT PASTEUR
Bacteria-cell interactions Unit – INSERM U604 – INRA USC2020
Department of Cell biology and Infection
25 rue du Docteur Roux -75724 PARIS Cedex 15-France.
E-mail: ascel.samba-louaka@pasteur.fr

Present position and status:  Post-doctoral fellow

Universitary education

2009  Ph.D in Cancerology, University of Paul Sabatier - Toulouse III, France.
2007  Animal experimentation authorization.
2006  Master of Cancerology, University of Paul Sabatier - Toulouse III, France.
2005  Maîtrise in Cellular Biology and Physiology, University of Henri Poincaré - Nancy I, France.
2004  Bachelor's degree in Cellular Biology and Physiology, University Paul Verlaine - Metz, France.

Research experience

Jul 2010-Present  Post-doctoral fellow; Bacteria Cell Interactions Unit.
Nov 2009-May 2010  Research Engineer; INRA/ENVT, UMR1225, Team: Molecular and Cellular pathogenesis of E. coli infections.
Project: evaluation of the “pks island” effect on different cell lines.
Oct 2006-Oct 2006  Ph.D student; INRA/ENVT, UMR1225, Team: Molecular and Cellular pathogenesis of E. coli infections.
Project: Determination of the signaling pathway hijacked by the bacterial toxin Cif.
2005-2006  Master student; INRA/ENVT, UMR1225, Team: Molecular and Cellular pathogenesis of E. coli infections.
Project: Determination of the signaling pathway hijacked by the bacterial toxin Cif.
2005  Maîtrise student; Medecine Faculty of Nancy, Laboratoire de Nutrition et Maladies Métaboliques.
Project: Role of sphingomyelin in differentiation of adipocytes.

Oral communications

2009  “The bacterial effector Cif blocks the host eukaryotic cell cycle and induces delayed apoptosis in epithelial cells.”
ETOX14 meeting, Obernai, France.
2008  “Discovery of a virulence factor in Escherichia coli.”
National Laboratory of Public Health (LNSP), Brazzaville, Congo.
  “Hijacking of eukaryotic cell cycle by E. coli.”
Institute of Pharmacology and Structural Biology (IPBS), Toulouse, France.
2006, 2007  “Impact of cyclomodulins on the risk of developing colorectal tumors.”
Ligue contre le cancer, Montauban, France.

Publication list

  • Jubelin G, Taieb F, Duda D, Hsu Y, Samba-Louaka A, Nobe R, Penary M, Watrin C, Nougayrède JP, Schulman BA, Stebbins CE and Oswald E. 2010. Pathogenic bacteria target NEDD8-conjugated cullins to block the host cell cycle. PLoS pathogens, 6, e1001128.
  • Samba-Louaka A, Nougayrede JP, Watrin C, Oswald E and Taieb F. 2009. The enteropathogenic Escherichia coli effector Cif induces delayed apoptosis in epithelial cells. Infect Immun 77, 5471-5477.
  • Jubelin G, Chavez CV, Taieb F, Banfield MJ, Samba-Louaka A, Nobe R, Nougayrède JP, Zumbihl R, Givaudan A, Escoubas JM and Oswald E. 2009. Cycle inhibiting factors (CIFs) are a growing family of functional cyclomodulins present in invertebrate and mammal bacterial pathogens. PLoS One 4, e4855.
  • Samba-Louaka A, Taieb F, Nougayrede JP and Oswald E. 2009. Cif type III effector protein: a smart hijacker of the host cell cycle. Future Microbiol 4, 867-877.
  • Samba-Louaka A, Nougayrede JP, Watrin C, Jubelin G, Oswald E and Taieb F. 2008. Bacterial cyclomodulin Cif blocks host cell cycle by stabilizing cyclin dependent kinase inhibitors p21(waf1) and p27(kip1). Cell Microbiol 10, 2496-2508.
  • Taieb F, Nougayrede JP, Watrin C, Samba-Louaka A and Oswald E. 2006. Escherichia coli cyclomodulin Cif induces G2 arrest of the host cell cycle without activation of the DNA-damage checkpoint-signalling pathway. Cell Microbiol 8, 1910-1921.