Ribet and Cossart (2010). Virulence 1:6, 532-534
Bacterial factors interfering with host cell SUMOylation. SUMOylation is a reversible post-translational modification consisting in the covalent
linkage of SUMO on a target protein. The conjugation of SUMO requires a set of E1, E2 and E3 SUMO enzymes, whereas deconjugation of SUMO is
mediated by SUMO-specific proteases called deSUM Oylases. Some bacterial factors (black diamonds) can interfere with the SUMOylation of the host
cell. The pore-forming toxins LLO, PFO and PLY trigger the degradation of the E2 SUMO enzyme (Ubc9) and the degradation of some host SUMOylated
proteins. XopD and putatively AvrXv4, two factors of X. campestris injected in the host cell cytoplasm during infection, act as deSUMOylases and lead
to the deSUM Oylation of some host proteins.